Reosseointegration Following Regenerative Therapy of Tissue‐Engineered Bone in a Canine Model of Experimental Peri‐Implantitis

Xu, Lianyi; Sun, Xiaojuan; Bai, Jue; Jiang, Li; Wang, Shaoyi; Zhao, Jun; Xia, Lunguo; Zhang, Xiuli; Wen, Ji; Li, Guanglong; Jiang, Xinquan

doi:10.1111/cid.12308

Cited by 25 publications

(56 citation statements)

References 36 publications

(80 reference statements)

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“…Notably, no immunological reactions related to the use of allogeneic or human cells were reported in these studies. Most studies reported on the use of bone marrow mesenchymal stem cells (BMSC); three studies used periosteal cells (POC) (Mizuno et al, ; Ribeiro et al, , b), two studies used periodontal ligament stem cells (PDLSC) (Kim et al, ; Park et al, ), two studies used adipose tissue‐derived MSC (Bressan et al, ; Xu et al, ) and one study used endothelial progenitor cells (Machtei et al, ). MSC were used in early (one to six) passages, with (seven studies) or without osteogenic pre‐induction.…”

Section: Resultsmentioning

confidence: 99%

Bone tissue engineering in oral peri-implant defects in preclinicalin vivoresearch: A systematic review and meta-analysis

Shanbhag

Pandis

Mustafa

et al. 2017

J Tissue Eng Regen Med

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The regeneration and establishment of osseointegration within oral peri-implant bone defects remains a clinical challenge. Bone tissue engineering (BTE) is emerging as a promising alternative to autogenous and/or biomaterial-based bone grafting. The objective of this systematic review was to answer the focused question: in animal models, do cell-based BTE strategies enhance bone regeneration and/or implant osseointegration in experimental peri-implant defects, compared with grafting with autogenous bone or only biomaterial scaffolds? Electronic databases were searched for controlled animal studies reporting on peri-implant defects and implantation of mesenchymal stem cells (MSC) or other cells seeded on biomaterial scaffolds, following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Random effects meta-analyses were performed for the outcomes histomorphometric bone area fraction (BA) and bone-to-implant contact (BIC). Nineteen studies reporting on large animal models (dogs and sheep) were included. Experimental defects were created surgically (16 studies) or via ligature-induced peri-implantitis (LIPI, three studies). In general, studies presented with an unclear to high risk of bias. In most studies, MSC were used in combination with alloplastic mineral phase or polymer scaffolds; no study directly compared cell-loaded scaffolds vs. autogenous bone. In three studies, cells were also modified by ex vivo gene transfer of osteoinductive factors. The meta-analyses indicated statistically significant benefits in favour of: (a) cell-loaded vs. cell-free scaffolds [weighted mean differences (WMD) of 10.73-12.30% BA and 11.77-15.15% BIC] in canine surgical defect and LIPI models; and (b) gene-modified vs. unmodified cells (WMD of 29.44% BA and 16.50% BIC) in canine LIPI models. Overall, heterogeneity in the meta-analyses was high (I 70-88%); considerable variation was observed among studies regarding the nature of cells and scaffolds used. In summary, bone regeneration and osseointegration in peri-implant defects are enhanced by the addition of osteogenic cells to biomaterial scaffolds. Although the direction of treatment outcome is clearly in favour of BTE strategies, due to the limited magnitude of treatment effect observed, no conclusive statements regarding the clinical benefit of such procedures for oral indications can yet be made. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Resultsmentioning

confidence: 99%

Bone tissue engineering in oral peri-implant defects in preclinicalin vivoresearch: A systematic review and meta-analysis

Shanbhag

Pandis

Mustafa

et al. 2017

J Tissue Eng Regen Med

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“…In this case, the test group, in addition to a hydroxyapatite carrier and rhBMP‐2 also included periodontal ligament stem cells, compared to the carrier control. Finally, also in Beagle dogs the combination of β‐TCP as a carrier plus rhBMP‐2 and adipose tissue derived stem cells, compared with several controls reported a histological bone gain of 2.81 mm in the test group versus 1.31 mm in the control group (Xu et al, ). In all these studies the addition of rhBMP‐2 demonstrated a significant added value when compared with the controls.…”

Section: Discussionmentioning

confidence: 98%

“…The ligature‐induced peri‐implantitis experimental model used for this study has been extensively used to study the pathophysiology of peri‐implant diseases and the efficacy of different therapeutic interventions (Albouy, Abrahamsson, & Berglundh, ; Albouy, Abrahamsson, Persson, & Berglundh, ; Berglundh, Gotfredsen, Zitzmann, Lang, & Lindhe, ; Berglundh, Lindhe, Marinello, Ericsson, & Liljenberg, ; Lindhe et al, ; Marinello et al, ; Martins, Ramos, Baptista, & Dard, ; Xu et al, ; Zitzmann, Berglundh, Ericsson, & Lindhe, ). The application of submarginal ligatures enhanced plaque accumulation and the development of peri‐implantitis, evidenced by bone loss and the development of peri‐implant bone defects, mainly circumferential (Carral et al, ; Schwarz et al, , ).…”

Section: Discussionmentioning

confidence: 99%

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The adjunctive effect of rhBMP‐2 on the regeneration of peri‐implant bone defects after experimental peri‐implantitis

Sanz‐Esporrín

Blanco

Sanz-Casado

et al. 2019

Clinical Oral Implants Res

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Objectives The aim was to evaluate the degree of bone regeneration and re‐osseointegration attained when combining a xenogeneic bone replacement graft plus rhBMP‐2 and a collagen membrane in ligature‐induced peri‐implantitis osseous defects in dogs. Material and Methods Thirty‐six implants were placed in a total of 6 Beagle dogs, 3 months after tooth extraction. Once experimental peri‐implantitis was induced, defects were randomly allocated into two treatment groups: in the test group guided bone regeneration was applied using de‐proteinized bovine bone mineral with 10% collagen soak loaded with rhBMP2 covered with a natural collagen membrane. In the control group, the same scaffold and membrane were used but saline was used to soak the grafting material. After a period of 8 weeks of healing, a submerged environment clinical measurements were taken and histological outcomes were evaluated once the animals were euthanized. Histological bone defect regeneration (BR) was considered as the primary outcome variable, and dog was selected as the unit of analysis. Results Partial defect resolution was observed in both treatment groups. The histometric analysis showed a higher degree of bone regeneration for the test group, although differences were not statistically significant, both in terms of histological bone gain and percentage of re‐osseointegration. Conclusions (a) The addition of rhBMP2 to a bovine xenograft/collagen vehicle carrier failed to provide a significant added value in terms of bone regeneration or re‐osseointegration, (b) partial re‐osseointegration of a previously contaminated surface was achieved, although (c) a complete defect resolution and re‐osseointegration to the level previous to the induction of the disease failed to occur in any of the treatment groups.

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“…Peri-implantitis is an inflammation occurring in osseous tissue surrounding the dental implant and can develop as a chronic progressive marginal inflammation, which can cause loss of bone tissue and function around the implant [1]. There are similarities in aspects of microbiology and clinical and pathological manifestations between peri-implantitis and periodontitis, but there are still differences in the rate and extent of inflammation, as well as in cell composition [2,3].…”

Section: Introductionmentioning

confidence: 99%

Osteoprotegerin Gene (OPG) Polymorphisms Associated with Peri-implantitis Susceptibility in a Chinese Han Population

Zhou

Zhao

2016

Med Sci Monit

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BackgroundThe aim of this study was to investigate the association between T950C (rs2073617) and G1181C (rs2073618) polymorphisms of the osteoprotegerin gene (OPG) and the susceptibility of peri-implantitis in the Chinese Han population.Material/Methods110 patients with peri-implantitis and 116 healthy persons from the Chinese Han population were included in this study using a case-control design; rs2073617 and rs2073618 in OPG were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The linkage disequilibrium (LD) and haplotype analysis were performed with Haploview software. Hardy-Weinberg equilibrium (HWE) was assessed in the control group based on the genotype distributions of OPG polymorphisms. The genotype, allele, and haplotype distribution differences between the case and control groups were analyzed by chi-square test, and the relative risk of PD was expressed by odds ratio (OR) and 95% confidence interval (CI).ResultsThe study results showed that people carrying the CC genotype of rs2073618 were more likely to have peri-implantitis than GG genotype carriers (OR=2.18, 95% CI=1.03–4.62, p=0.04). In addition, patients with the C allele had 1.47 times the risk of suffering from peri-implantitis (OR=1.47, 95% CI=1.01–2.13, p=0.04), but not rs2073617 polymorphism. The G-C haplotype frequency of rs2073618-rs2073617 in OPG was significantly correlated to the increased susceptibility of peri-implantitis (OR=2.27, 95% CI=1.20–4.30).ConclusionsOPG rs2073618 polymorphism may be related to the risk of peri-implantitis, but not rs2073617. Moreover, haplotype is also a non-ignorable risk factor.

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Reosseointegration Following Regenerative Therapy of Tissue‐Engineered Bone in a Canine Model of Experimental Peri‐Implantitis

Abstract: These data demonstrated that tissue engineered bone of ASCs, BMP-2 gene delivery, and β-TCP could exert powerful therapeutic effect on peri-implantitis as expected, which may suggest a feasible way to maintain the stability and masticatory function of dental implant.

Cited by 25 publications

References 36 publications

Bone tissue engineering in oral peri-implant defects in preclinicalin vivoresearch: A systematic review and meta-analysis

Bone tissue engineering in oral peri-implant defects in preclinicalin vivoresearch: A systematic review and meta-analysis

The adjunctive effect of rhBMP‐2 on the regeneration of peri‐implant bone defects after experimental peri‐implantitis

Osteoprotegerin Gene (OPG) Polymorphisms Associated with Peri-implantitis Susceptibility in a Chinese Han Population

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