Reordering Marriage and Society in Reformation Germany. By Joel F. Harrington (Cambridge: Cambridge University Press, 1995. xv plus 315pp.)

Watt, Jeffrey R.

doi:10.1353/jsh/30.2.534

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Adhesion At the Basement Membrane1

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2011

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“…Early in vitro experiments indicated that releasing keratinocytes from an underlying matrix induced cell cycle withdrawal and expression of differentiation markers 9,10 . In intact epidermis, keratinocytes cease proliferating as they leave the basal layer, which coincides with loss of contact with the basement membrane and suppression of integrin expression.…”

Section: Adhesion At the Basement Membranementioning

confidence: 99%

Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis

Simpson

Patel

Green

2011

Nat Rev Mol Cell Biol

413

395

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To provide a stable environmental barrier, the epidermis requires an integrated network of cytoskeletal elements and cellular junctions. Nevertheless, the epidermis ranks among the body’s most dynamic tissues, continually regenerating itself and responding to cutaneous insults. As keratinocytes journey from the basal compartment towards the cornified layers, they completely reorganize their adhesive junctions and cytoskeleton. These architectural components are more than just rivets and scaffolds — they are active participants in epidermal morphogenesis that regulate epidermal polarization, signalling and barrier formation.

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Section: Adhesion At the Basement Membranementioning

confidence: 99%