Renovascular hypertension and coronary heart disease complicating essential thrombocythemia

Arnar, Davíð O.; Pétursson, M. K.; Jonmundsson, E.; Björnsdóttir, J.

doi:10.1093/eurheartj/14.4.576

Cited by 5 publications

(6 citation statements)

References 6 publications

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“…Moreover, a regression by cytoreductive therapy of a renal artery stenosis, unsuccessfully treated with renal angioplasty, was reported. [5] Finally, the morphological characteristics of the renal artery stenosis in the present case ( figure 1) were not typical of a fibrodysplasic lesion, which is the most common cause of renovascular disease in younger patients. The pathogenesis of thrombophilic diathesis in essential thrombocythaemia is still not fully understood.…”

Section: Discussioncontrasting

confidence: 45%

Secondary Hypertension and Essential Thrombocythaemia

Bruno

Mazzi

Paco

et al. 2010

High Blood Pressure & Cardiovascular Prevention

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A 26-year-old man visited the Outpatient , for uncontrolled hypertension under a two-drug antihypertensive treatment. He had been previously diagnosed with essential thrombocythaemia and had been prescribed aspirin (acetylsalicylic acid) 100 mg day since he was 20 years old, with a stable platelet count of about 700 000-800 000. High blood pressure lasted 3 months and was treated with lisinopril 20 mg day. One month before the visit he had an acute coronary syndrome, with normal coronary angiogram, and clopidogrel 75 mg day and amlodipine 5 mg day were added at discharge. At the Hypertension Unit, a bilateral renal artery stenosis was diagnosed, accompanied by cardiac and renal target organ damage. Moreover, a total occlusion of the right carotid artery was found. The patient underwent bilateral percutaneous renal angioplasty with stent placement. He was discharged with interferon-a-2b, aspirin and warfarin and with no antihypertensive therapy, having blood pressure values of 100 70 mmHg. A few months later he became hypertensive again and lisinopril 20 mg day was prescribed, while platelet count was reduced to 500 000. Nine months later he died of a sudden death.

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Section: Discussioncontrasting

confidence: 45%

Secondary Hypertension and Essential Thrombocythaemia

Bruno

Mazzi

Paco

et al. 2010

High Blood Pressure & Cardiovascular Prevention

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“…Arnar et al reported a 36-year-old male with essential thrombocytosis and resistant hypertension [30]. Aorto-renal angiography of the patient revealed critical bilateral renal artery stenosis and coronary angiography showed three-vessel disease.…”

Section: Discussionmentioning

confidence: 99%

“…There is also limited number of reports about the involvement of the renal arteries [30][31][32][33][34]. Arnar et al reported a 36-year-old male with essential thrombocytosis and resistant hypertension [30].…”

Section: Discussionmentioning

confidence: 99%

Multiple coronary thrombosis and stent implantation to the subtotally occluded right renal artery in a patient with essential thrombocytosis: A case report with review

Özben

Ekmekçi

Buğra

et al. 2006

J Thromb Thrombolysis

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Essential thrombocytosis is a myeloproliferative disorder of unknown etiology manifested clinically by the overproduction of platelets in the absence of a definable cause. Platelet dysfunction in essential thrombocytosis results in both hemorrhage and thrombosis. It is one of the rare causes of ischemic cardiovascular events. Fewer than 20 cases of essential thrombocytosis with involvement of coronary arteries leading to acute coronary syndromes or myocardial infarction have been reported. We report a case of multiple coronary thrombosis involving the left anterior descending artery and circumflex artery and stent implantation to the subtotally stenotic right renal artery in a women with unstable angina pectoris, essential thrombocytosis and previous history of renal artery trombosis.

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“…Pathologically, arterial occlusions are primarily microvascular; however, larger arteries may also be involved. Although uncommon, thrombosis of the arterial system involving the coronary [13][14][15][16][17], renal [18][19][20], peripheral [21,22], and digital arteries [23], and the venous system involving the portal vein [24] and the sagittal sinus [25] has been reported as a complication of ET. This disease may also complicate pregnancy, causing recurrent abortions and fetal growth retardation [26].…”

Section: Discussionmentioning

confidence: 99%