Multiple coronary thrombosis and stent implantation to the subtotally occluded right renal artery in a patient with essential thrombocytosis: A case report with review

Özben, Beste; Ekmekçi, Ahmet; Buğra, Zehra; Umman, Sabahattin; Meriç, Mehmet

doi:10.1007/s11239-006-7790-8

Cited by 22 publications

(23 citation statements)

References 31 publications

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“…Recently, the consumption of polyphenol-rich foods, including vegetables and fruits, was reported to reduce the risk for acute coronary disease incidence, which was closely associated with thrombosis (Ozben et al, 2006;Park et al, 2008). Therefore, antithrombotic agent development from medicinal plants with little side effects has at-tracted much interest (Vitseva et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Antiplatelet and Antithrombotic Activities of Lindera obtusiloba Extract in vitro and in vivo

Lee¹,

Kim²,

Lee³

et al. 2010

Biomolecules and Therapeutics

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-Several studies have shown that plant-derived polyphenols reduce cardiovascular accidents in high-risk patients and the inhibition of platelet function may be responsible for part of this benefit. Lindera obtusiloba is widely used in traditional herbal medicine for the treatment of cardiovascular and inflammatory diseases. Therefore, the antiplatelet and antithrombotic activities of Lindera obtusiloba Extracts (LOE) on in vitro platelet aggregation, radical scavenging activity and in vivo murine pulmonary thrombosis were examined. LOE was able to directly scavenge the stable DPPH radical in a concentration-dependent manner and its IC50 value was 3.9 ± 0.1 μg/ml. LOE significantly inhibited collagen-and ADP-induced platelet aggregation in a concentration-dependent manner and its IC 50 value is 0.9 ± 0.1 mg/ml and 0.4 ± 0.1 mg/ml respectively. The inhibitory effect of LOE was comparable to aspirin (IC50 values were 1.0 ± 0.5 and 1.0 ± 0.7 mg/ml, respectively). Furthermore, oral administration of LOE suppressed the death of mice with pulmonary thrombosis induced by intravenous injection of collagen plus epinephrine. Taken together, our results suggest LOE may be a promising candidate for antithrombotic agent, and the antithrombotic effect of LOE may be due to, at least in part, antiplatelet activity.

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Section: Discussionmentioning

confidence: 99%

Antiplatelet and Antithrombotic Activities of Lindera obtusiloba Extract in vitro and in vivo

Lee¹,

Kim²,

Lee³

et al. 2010

Biomolecules and Therapeutics

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“…Essential thrombocytosis can be complicated by both thrombotic and/or hemorrhagic sequelae. De Novo coronary thrombus is rare, but has been described in literature [2][3][4][5][6][7][8][9][10][11]. We present a patient with ET and an unusual presentation of inferior myocardial infarction secondary to paradoxical embolus through a patent foramen ovale (PFO) in the setting of acute pulmonary embolism.…”

Section: Introductionmentioning

confidence: 99%

ST-elevation myocardial infarction secondary to paradoxical coronary emboli in a patient with massive pulmonary embolism and essential thrombocytosis: A case report

Almehmadi¹,

Mehdar²,

Sridhar³

et al. 2015

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations. Essential thrombocytosis (ET) is a myeloproliferative disorder with higher incidence of thrombotic events. To our knowledge, we present the first case of ST-segment elevation myocardial infarction (STEMI) secondary to paradoxical right coronary artery (RCA) embolus through a patent foramen ovale (PFO) in a patient with essential thrombocytosis and pulmonary embolus. Case Report: A 67-year old female with a history of ET presented to the emergency room with dyspnea. Physical examination revealed an elevated JVP, an S1Q3T3 pattern on her presenting ECG, and an elevated D-dimer. V/Q scan showed a high probability for pulmonary embolism as well as unusual evidence of right-to-left cardiac shunting. After starting low molecular weight heparin, she developed new-onset chest pain and her ECG showed ST-elevation in the inferior leads. Emergency left and right heart catheterization showed an acutely occluded RCA with heavy thrombus burden. This was managed successfully with thrombus aspiration only. Massive bilateral pulmonary embolism was seen on thoracic computed tomography (CT) scan, which was managed by systemic thrombolysis. A Transesophageal echocardiogram was performed, which confirmed a patent PFO with right-to-left shunting. The patient was treated medically with dual antiplatelets, anticoagulation with heparin and hydroxyurea. Given the degree of thrombotic burden PFO closure was not performed and the patient was managed conservatively with lifelong anticoagulation. The patient has been followed closely, and three years post-event, she has done remarkably well on warfarin with no evidence of further thromboembolism. Conclusion:We describe the first case of paradoxical coronary artery embolism through a PFO in a patient with ET and massive PE. Our patient was managed conservatively on oral anticoagulation without further thromboembolic events at three years post-event.

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“…Thrombosis is also the major cause of morbidity and mortality. 2 Although arterial occlusions are microvascular, thrombosis of the coronary, renal, peripheral, and digital arteries have also been reported. 2 Coronary artery involvement leading to acute coronary syndromes is a rare complication of the ET and few case reports have been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

“…2 Although arterial occlusions are microvascular, thrombosis of the coronary, renal, peripheral, and digital arteries have also been reported. 2 Coronary artery involvement leading to acute coronary syndromes is a rare complication of the ET and few case reports have been reported in the literature. 3 We report a 30-year-old female patient with an acute ST-segment elevation (MI) as the first clinical sign of essential thrombocythemia.…”

Section: Introductionmentioning

confidence: 99%

Essential Thrombocythemia: A Case of Acute ST‐Segment Elevation Myocardial Infarction in a Young Female

Bildirici

Ural

2009

Clinical Cardiology

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Essential thrombocythemia (ET) is a clonal disorder of the myeloid stem cell that causes abnormal proliferation of the megakaryocytes. The main feature of the disease is arterial and venous thrombosis caused by platelet dysfunction. Coronary artery involvement leading to acute coronary syndromes is a rare complication of the ET. We report a coronary angioplasty and stenting in a 30-year-old female patient with acute ST-segment elevation myocardial infarction (MI) as the first clinical sign of essential thrombocythemia. Facilitated percutaneous coronary intervention with GPIIb/IIIa and/or thrombolytic therapy may be considered as the first treatment modality for this patient group.

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Multiple coronary thrombosis and stent implantation to the subtotally occluded right renal artery in a patient with essential thrombocytosis: A case report with review

Cited by 22 publications

References 31 publications

Antiplatelet and Antithrombotic Activities of Lindera obtusiloba Extract in vitro and in vivo

Antiplatelet and Antithrombotic Activities of Lindera obtusiloba Extract in vitro and in vivo

ST-elevation myocardial infarction secondary to paradoxical coronary emboli in a patient with massive pulmonary embolism and essential thrombocytosis: A case report

Essential Thrombocythemia: A Case of Acute ST‐Segment Elevation Myocardial Infarction in a Young Female

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