Renoprotective effect of Tanshinone IIA, an active component of Salvia miltiorrhiza, on rats with chronic kidney disease

Abstract

Chronic kidney disease (CKD) is a common cause of end-stage renal disease. Antihypertensive agents are used clinically to inhibit the progression of CKD, but cannot prevent eventual renal failure. This study investigated the effect of Tanshinone IIA, an active component of Salvia miltiorrhiza, in rats suffering from CKD induced by 5/6 nephrectomy. After development of renal insufficiency, the rats were treated with Tanshinone IIA (10 mg/kg) for 8 weeks. Serum creatinine, angiotensin II (Ang II), transforming growth factor β1 (TGF-β1) and collagen IV levels were significantly reduced in Tanshinone IIA treated rats compared with a control group. In addition, Tanshinone IIA suppressed increases in urinary protein excretion in CKD rats. These findings suggest that chronic oral administration of Tanshinone IIA can improve renal dysfunction associated with CKD.

The protective effect of Salvia miltiorrhiza in an animal model of early experimentally induced diabetic nephropathy

“…SM was traditionally reported to have effects of improving circulation and removing blood stasis (Zhou et al, 2005). The extracts or various active components of SM were shown both in vitro and in vivo to improve blood microcirculation and increase overall blood flow (Zhou et al, 2005;Ahn et al, 2010;Leung et al, 2010). However, there have been no studies including TGF-␤1, collagen IV, ED-1, and RAGE, all of which play central roles in the progressive deterioration of DN.…”

Association of prescribed Chinese herbal medicine use with risk of end-stage renal disease in patients with chronic kidney disease

“…Previous animal studies have reported that some components of Chinese herbs might exert renoprotective effects. [27][28][29][30][31][32][33][34] However, these animal study results were only weakly confirmed by a human study. 35 The method used in the current study enabled us to identify potentially beneficial formulas and those with potential renal toxicity.…”

Pharmacokinetic comparisons of single herb extract of Fufang Danshen preparation with different combinations of its constituent herbs in rats

“…Radix S. miltiorrhiza (S. miltiorrhiza), a key constituent herb in FDT (monarch), has been commonly prescribed for the treatment of coronary heart disease, cerebrovascular disease, hepatitis, hepatocirrhosis and chronic renal failure in clinical situations [3][4][5]. Salvianolic acid B (SAB) and tanshinone IIA (TS) have been used as phytochemical markers for the quality control of S. miltiorrhiza and its preparations in Chinese pharmacopeia.…”