Pharmacokinetic comparisons of single herb extract of Fufang Danshen preparation with different combinations of its constituent herbs in rats

Yang, Shenshen; Zhang, Keru; Xia, Lin; Miao, Yifan; Meng, Lingkuo; Chen, Wei; Tang, Xing

doi:10.1016/j.jpba.2012.03.058

Cited by 36 publications

(23 citation statements)

References 25 publications

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“…However, another rat study reported oral administration of Fufang Danshen preparation or salvianolic acid B extract alone or in the presence of Sanqi, Borneol, and tanshinones extract had the same salvianolic acid B pharmacokinetics. Similar results were found for tanshinone IIA [81]. Using Guinea pigs as the animal model, the values of C max and AUC of salvianolic acid B in plasma decreased by 35% and 37%, respectively, and the corresponding values of tanshinone IIA decreased by 91% and 84%, respectively, after intratympanic administration of Danshen and Sanqi.…”

Section: Pharmacokinetic Alterations Of Danshen Bioactive Constitusupporting

confidence: 76%

Salvia miltiorrhizaRoots against Cardiovascular Disease: Consideration of Herb-Drug Interactions

Chen¹,

Tian

2017

BioMed Research International

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Salvia miltiorrhiza root (Danshen) is widely used in Asia for its cardiovascular benefits and contains both hydrophilic phenolic acids and lipophilic tanshinones, which are believed to be responsible for its therapeutic efficacy. This review summarized the effects of these bioactive components from S. miltiorrhiza roots on pharmacokinetics of comedicated drugs with mechanic insights regarding alterations of protein binding, enzyme activity, and transporter activity based on the published data stemming from both in vitro and in vivo human studies. In vitro studies indicated that cytochrome P450 (CYP450), carboxylesterase enzyme, catechol-O-methyltransferase, organic anion transporter 1 (OAT1) and OAT3, and P-glycoprotein were the major targets involved in S. miltiorrhiza-drug interactions. Lipophilic tanshinones had much more potent inhibitory effects towards CYPs activities compared to hydrophilic phenolic acids, evidenced by much lower Ki values of the former. Clinical S. miltiorrhiza-drug interaction studies were mainly conducted using CYP1A2 and CYP3A4 probe substrates. In addition, the effects of coexisting components on the pharmacokinetic behaviors of those noted bioactive compounds were also included herein.

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Section: Pharmacokinetic Alterations Of Danshen Bioactive Constitusupporting

confidence: 76%

Salvia miltiorrhizaRoots against Cardiovascular Disease: Consideration of Herb-Drug Interactions

Chen¹,

Tian

2017

BioMed Research International

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“…The analysis of monoingredients or single herbs may not represent the pharmacokinetics of the whole composite prescription. Thus, it is better to investigate the pharmacokinetics of multiple components and compare the pharmacokinetic differences between single herbs and the whole prescription (Yang et al, 2012;Zheng et al, 2011). Huo Luo Xiao Ling Dan (HLXLD), a classical formulae, was originally described by Xichun Zhang (in the Chinese Qing Dynasty) in his treatise Records of Heart-felt Experiences in Medicine with Reference to the West (1918).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic comparison of five tanshinones in normal and arthritic rats after oral administration of Huo Luo Xiao Ling Dan or its single herb extract by UPLC‐MS/MS

Peng

Wang

et al. 2016

Biomedical Chromatography

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A fast, sensitive and reliable ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method has been developed and validated for simultaneous quantitation and pharmacokinetic study of five tanshinones (tanshinone I, tanshinone IIA, tanshinone IIB, dihydrotanshinone I, cryptotanshinone), the bio-active ingredients of Huo Luo Xiao Ling Dan (HLXLD) in rat plasma. After liquid-liquid extraction, chromatographic separation was accomplished on a Shim-pack XR-ODS column (75 × 3.0 mm, 2.2 µm particles) and eluted with a mobile phase consisting of acetonitrile-0.05% formic acid aqueous solution (80:20, v/v) at a flow rate of 0.4 mL/min, and the total run time was 7.0 min. The detection was performed on a triple quadrupole tandem mass spectrometry equipped with an electrospray ionization source in positive ionization and multiple reaction monitoring mode. The lower limits of quantification were 0.050-0.400 ng/mL for all the analytes. Linearity, precision and accuracy, the mean extraction recoveries and matrix effects all satisfied criteria for acceptance. This validated method was successfully applied to a comparative pharmacokinetic study of five bio-active components in rat plasma after oral administration of HLXLD or Salvia miltiorrhiza extract in normal and arthritic rats. The results showed that there were different pharmacokinetic characteristics among different groups. Copyright © 2016 John Wiley & Sons, Ltd.

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“…in the Chinese Pharmacopeia since 1977 for improving coronary and cerebral circulation. 4 More than 100 compounds have been isolated and identified in S. miltiorrhiza and P. notoginseng to date, 5,6 but only a fraction of these compounds were confirmed to be responsible for their biological effects. 7,8 Salvianolic acid B (SalB) from S. miltiorrhiza, accompanied by ginsenoside Rg1 (Rg1) and ginsenoside Rb1 (Rb1) from P. notoginseng, have been used as phytochemical markers for the quality control of Danqi tablet.…”

Section: Introductionmentioning

confidence: 99%

Ginsenoside Rg1 and Rb1, in combination with salvianolic acid B, play different roles in myocardial infarction in rats

Deng

Zhang

Teng

et al. 2015

Journal of the Chinese Medical Association

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Pharmacokinetic comparisons of single herb extract of Fufang Danshen preparation with different combinations of its constituent herbs in rats

Cited by 36 publications

References 25 publications

Salvia miltiorrhizaRoots against Cardiovascular Disease: Consideration of Herb-Drug Interactions

Salvia miltiorrhizaRoots against Cardiovascular Disease: Consideration of Herb-Drug Interactions

Pharmacokinetic comparison of five tanshinones in normal and arthritic rats after oral administration of Huo Luo Xiao Ling Dan or its single herb extract by UPLC‐MS/MS

Ginsenoside Rg1 and Rb1, in combination with salvianolic acid B, play different roles in myocardial infarction in rats

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