Renin-angiotensin system polymorphisms in relation to hypertension status and obesity in a Tunisian population

Mehri, Sounira; Mahjoub, S.; Hammami, S.; Zaroui, Amira; Frih, A.; Betbout, Fethi; Mechmèche, Rachid; Hammami, Mohamed

doi:10.1007/s11033-011-1187-2

Cited by 50 publications

(50 citation statements)

References 37 publications

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“…in Utah and France [24]. Subsequently, cases of associations between the same genotype TT and the risk of hypertension in other populations have been reported [20,21,25,26]. Nevertheless, we did not find any evidence of association between AGT 235M/T polymorphism and the incidence of hypertension in our study population.…”

Section: Discussioncontrasting

confidence: 71%

“…This result showed a strong association between the ACE I/D polymorphism and the risk of hypertension in the Burkinabe population ( < 0.0001). Mehri et al [26] and Jiménez et al [27] also reported strong associations between the DD genotype and the risk of hypertension in their study populations. However, Castellano et al [28] did not find any evidence of association between the D allele and the risk of hypertension in the Italian population.…”

Section: Discussionmentioning

confidence: 78%

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Renin-angiotensin system genes polymorphisms and essential hypertension in Burkina Faso, West Africa

Kologo¹,

Tchelougou²,

Karou³

et al. 2017

Archives of Cardiovascular Diseases Supplements

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Objective. This study aimed to investigate the association between three polymorphisms of renin-angiotensin system and the essential hypertension in the population of Burkina Faso. Methodology. This was a case-control study including 202 cases and 204 matched controls subjects. The polymorphisms were identified by a classical and a real-time PCR. Results. The AGT 235M/T and AT1R 1166A/C polymorphisms were not associated with the hypertension while the genotype frequencies of the ACE I/D polymorphism between patients and controls (DD: 66.83% and 35.78%, ID: 28.22% and 50.98%, II: 4.95% and 13.24%, resp.) were significantly different (p < 10 −4 ). The genotype DD of ACE gene (OR = 3.40, p < 0.0001), the increasing age (OR = 3.83, p < 0.0001), obesity (OR = 4.84, p < 0.0001), dyslipidemia (OR = 3.43, p = 0.021), and alcohol intake (OR = 2.76, p < 0.0001) were identified as the independent risk factors for hypertension by multinomial logistic regression. Conclusion. The DD genotype of the ACE gene is involved in susceptibility to hypertension. Further investigations are needed to better monitor and provide individualized care for hypertensive patients.

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Section: Discussioncontrasting

confidence: 71%

Section: Discussionmentioning

confidence: 78%

Renin-angiotensin system genes polymorphisms and essential hypertension in Burkina Faso, West Africa

Kologo¹,

Tchelougou²,

Karou³

et al. 2017

Archives of Cardiovascular Diseases Supplements

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show abstract

“…[11][12][13]18,23,[54][55][56]59,60,62,64,[66][67][68] Only two studies involved an African population. 17,18 …”

Section: Baseline Characteristicsmentioning

confidence: 99%

Association of AT1R polymorphism with hypertension risk: An update meta-analysis based on 28,952 subjects

Liu

Zhang²,

et al. 2015

J Renin Angiotensin Aldosterone Syst

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Background: Previous studies have shown that angiotensin II AT1 receptor gene (AT1R) polymorphisms are associated with the risk for hypertension. However, the results remain controversial. In the present study, we performed a meta-analysis to systematically summarize the association between AT1R genetic polymorphisms and the risk for hypertension. Methods: We searched the literature in PubMed, EMBASE, ISI Web of Science, Wanfang, and Chinese National Knowledge Infrastructure databases (CNKI) to find case-control studies on the associations of AT1R genetic polymorphisms with the risk for hypertension. The meta-analysis was performed by using RevMan 5.0 software. The association of hypertension risk with AT1R genetic polymorphism was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). Results: Fifty-six studies involving 28,952 subjects were included in the present meta-analysis. Our results suggest that the polymorphism (A1166C) of AT1R gene is associated with a statistically increased hypertension risk, not only in Asian populations but also in Caucasian populations. We did not find any association in African populations. Conclusions: This meta-analysis suggests that A1166C polymorphism in the AT1R gene is associated with the risk of hypertension in Asian and Caucasian populations.

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“…Therefore, we included 12 studies 8,[10][11][12][13][14][15][17][18][19][20][21] in the sensitivity analysis.…”

Section: Sensitivity Analysismentioning

confidence: 99%

“…However, a number of investigations regarding the association between ACE I/D gene polymorphism and overweight/ obesity risk have generated mixed results in human studies. 5,8,[10][11][12][13][14][15][16][17][18][19][20][21] The contribution of ACE I/D gene polymorphism to the onset of overweight/ obesity is still unclear. Metaanalysis of the association between ACE I/D gene polymorphism and overweight/obesity risk is rare.…”

Section: Introductionmentioning

confidence: 99%

A meta-analysis of the association between angiotensin-converting enzyme insertion/ deletion gene polymorphism and the risk of overweight/obesity

Mao

Huang

2013

J Renin Angiotensin Aldosterone Syst

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Background and objective:The association between angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism and the risk of overweight/obesity remains controversial. A meta-analysis was conducted to evaluate the association between ACE I/D gene polymorphism and overweight/obesity susceptibility. Method: All eligible studies were included in this meta-analysis by searching PubMed, Embase and Cochrane databases through April 2013 according to a predefined criteria. Results: Fourteen case-control studies including 3371 cases and 4490 controls were recruited for the analysis of the association between ACE I/D gene polymorphism and overweight/obesity susceptibility. A significant association was observed between DD genotype and overweight/obesity risk in overall populations and Africans (p=0.014 and 0.010, respectively). D allele was associated with the risk of overweight/ obesity in Africans (p=0.026). However, II genotype might not be a protective factor against overweight/obesity risk in overall populations, Africans, Caucasians and Asians. Conclusions: DD genotype is a risk factor for the overweight/obesity susceptibility in overall populations, particularly in Africans. D allele is a risk factor for the overweight/obesity susceptibility in Africans. Further larger studies are needed to confirm our findings.

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Renin-angiotensin system polymorphisms in relation to hypertension status and obesity in a Tunisian population

Cited by 50 publications

References 37 publications

Renin-angiotensin system genes polymorphisms and essential hypertension in Burkina Faso, West Africa

Renin-angiotensin system genes polymorphisms and essential hypertension in Burkina Faso, West Africa

Association of AT1R polymorphism with hypertension risk: An update meta-analysis based on 28,952 subjects

A meta-analysis of the association between angiotensin-converting enzyme insertion/ deletion gene polymorphism and the risk of overweight/obesity

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