Association of AT1R polymorphism with hypertension risk: An update meta-analysis based on 28,952 subjects

Abstract

Background: Previous studies have shown that angiotensin II AT1 receptor gene (AT1R) polymorphisms are associated with the risk for hypertension. However, the results remain controversial. In the present study, we performed a meta-analysis to systematically summarize the association between AT1R genetic polymorphisms and the risk for hypertension. Methods: We searched the literature in PubMed, EMBASE, ISI Web of Science, Wanfang, and Chinese National Knowledge Infrastructure databases (CNKI) to find case-control studies on the associations of AT1R genetic polymorphisms with the risk for hypertension. The meta-analysis was performed by using RevMan 5.0 software. The association of hypertension risk with AT1R genetic polymorphism was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). Results: Fifty-six studies involving 28,952 subjects were included in the present meta-analysis. Our results suggest that the polymorphism (A1166C) of AT1R gene is associated with a statistically increased hypertension risk, not only in Asian populations but also in Caucasian populations. We did not find any association in African populations. Conclusions: This meta-analysis suggests that A1166C polymorphism in the AT1R gene is associated with the risk of hypertension in Asian and Caucasian populations.

Genetic factors contributing to hypertension in African‐based populations: A systematic review and meta‐analysis

“…We observed an association between rs5186 and hypertension, which is in contrast to findings from a meta-analysis by Liu and coworkers 46 in African Americans. Instead, Liu and associates 46 observed the rs5186-hypertension association in Asians and Caucasians in support of findings reported elsewhere.…”

“…We observed an association between rs5186 and hypertension, which is in contrast to findings from a meta-analysis by Liu and coworkers 46 in African Americans. Instead, Liu and associates 46 observed the rs5186-hypertension association in Asians and Caucasians in support of findings reported elsewhere. 45,47 Our meta-analysis also suggests an association of rs699 with hypertension, similar to studies conducted in Asians, 48,49 while no association between any of the common SNPs found in RAAS genes and hypertension has been reported by other authors.…”

“…We conducted meta‐analyses of three SNPs in three genes of the RAAS: ACE I/D (rs4340), AGT M235T (rs699), and AGTR1 1166A>C (rs5186) to achieve an optimum power. We observed an association between rs5186 and hypertension, which is in contrast to findings from a meta‐analysis by Liu and coworkers in African Americans. Instead, Liu and associates observed the rs5186‐hypertension association in Asians and Caucasians in support of findings reported elsewhere .…”

“…Alternatively, this SNP may be involved in regulation of AGTR1 expression. Despite the elusive function of the rs5186 SNP, the AGTR1 has been selected as the potential treatment target for hypertension because of its evident association with hypertension in certain population groups and effectiveness of its antagonists as antihypertensive therapy . However, BP‐lowering efficacy of RAAS inhibitors is not evident in African Americans, probably because of their low renin profile and sensitivity to salt intake .…”

Renin–angiotensin system gene polymorphisms and endometrial cancer

“…The CC genotype is associated with an increased expression of AGTR1, with a 2.4 times higher chance of hypertension (22, 23). This polymorphism is also associated with an increased risk of renal cell carcinoma (24).…”