Renin-angiotensin-aldosterone system in new coronavirus infection 2019

Загидуллин, Н. Ш.; Gareeva, Diana; Ишметов, В. Ш.; Павлов, А. В.; Плотникова, М. Р.; Пушкарева, А. Э.; Павлов, В. Н.

doi:10.18705/1607-419x-2020-26-3-240-247

Cited by 9 publications

(7 citation statements)

References 37 publications

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“…2 , Загидуллин Н. Ш. 1 Новая коронавирусная инфекция (COVID-19) поражает не только органы дыхания, но и в 20-28% случаев сердечно-сосудистую систему, вызывая дисфункцию эндотелия, васкулиты, гипер-и гипокоагуляцию, миокардиты, эндотелиальную дисфункцию и другие неблагоприятные эффекты. Было показано, что наличие сердечно-сосудистых факторов риска и заболеваний ухудшает тяжесть течения болезни и повышает летальность от COVID-19.…”

Section: предикторные сывороточные биомаркеры поражения сердечно-сосудистой системы при Covid-19unclassified

“…Отношения и деятельность: нет. 1 ФГБОУ ВО Башкирский государственный медицинский университет Минздрава России, Уфа, Россия; 2 Университетская клиника внутренних болезней II, Медицинский университет Парацельса, Зальцбург, Австрия.…”

Section: предикторные сывороточные биомаркеры поражения сердечно-сосудистой системы при Covid-19unclassified

“…SARS-CoV-2 представляет собой одноцепочечный РНК-вирус, относящийся к родам Betacoronavirus и Sarbecovirus. Он проникает в клетки посредством связывания белка шипа вируса с рецептором ангиотензинпревращающего фермента 2 (АПФ2) [1]. АПФ2 активно экспрессируется в альвеолярных клетках легких, обеспечивая путь проникновения вируса [2].…”

Section: Serum Biomarkers Of Cardiovascular Complications In Covid-19unclassified

“…Также определена сильная корреляция между концентрацией ИЛ-6 и степенью эндотелиальной дисфункции, опосредованной через АТ-II [33]. АПФ2 преобразует АТ-II в АТ-(1-7) и АТ-I -в АТ- (1)(2)(3)(4)(5)(6)(7)(8)(9). АТ-(1-7) и АТ-(1-9) вызывают соответствующие эффекты через рецепторы Mas и AT2R, соответственно.…”

Section: растворимая изоформа -Sst2unclassified

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Serum biomarkers of cardiovascular complications in COVID-19

et al. 2021

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The coronavirus disease 2019 (COVID-19) affects not only the respiratory system, but also the cardiovascular system in 20-28% of cases, causing endothelial dysfunction, vasculitis, hyper- and hypocoagulation, myocarditis, endothelial dysfunction and other adverse effects. The presence of cardiovascular risk factors and diseases has been shown to worsen the disease severity and increase mortality from COVID-19. Recent studies have also found that elevations in some serum cardiovascular biomarkers can stratify the disease severity, in particular rates of hospitalizations to an internal medicine or intensive care unit, intubation, and mortality. They can be divided into markers of damage (TnT/I, creatine phosphokinase (CPK) and CPK-MB, myoglobin, NT-proBNP), coagulation (prothrombin time, fibrinogen and D-dimer), as well as prospective biomarkers for which the available evidence base is limited but there is a pathophysiological rationale (homocysteine and sST2). This review presents studies on the use of above serum biomarkers to stratify the risk of death in patients with COVID-19.

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Section: предикторные сывороточные биомаркеры поражения сердечно-сосудистой системы при Covid-19unclassified

Section: Serum Biomarkers Of Cardiovascular Complications In Covid-19unclassified

Section: растворимая изоформа -Sst2unclassified

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Serum biomarkers of cardiovascular complications in COVID-19

et al. 2021

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“…Одной из причин повышенного риска последствий КВИ при ОЖ является активность ангиотензинпревращающего фермента 2 (ACE2) [8,9]. Установлено, что при избыточном весе активируется экспрессия участков генов, ответственных за образование белка ACE 2 [10,11]. Именно этот белок является «входными воротами», через которые в клетку проникает вирус SARS-CoV-2.…”

Section: патофизиология тяжелого течения коронавирусной инфекции на фоне ожиренияunclassified

Coronavirus Infection an Obese Patient (Literature Review)

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Pimankina

2021

Arhivʺ vnutrennej mediciny

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In the modern world the problem of obesity in combination with new coronavirus infection has acquired a special danger. On the one hand, the prevalence of obesity among the population is steadily increasing, on the other-it has been proven that obese people are among the most vulnerable in terms of increased risk of infection and a serious prognosis. This is due to the presence and peculiarities of the development of various pathological mechanisms in this category of patients. These include: high expression of angiotensin-converting enzyme 2, a high probability of a «cytokine storm» developing, maintenance of a chronic inflammatory process in adipose tissue, changes in the activity of Dipeptidyl peptidase-4 enzyme. All these processes lead to an aggravation of metabolic disorders in adipose tissue and violation of immune protection. The world medical practice in the fight against the COVID-19 pandemic shows that patients with coronavirus infection against the background of obesity more often need hospitalization in intensive care units and connection to artificial ventilation equipment. Currently, many features of the course of coronavirus infection against the background of obesity have been identified and continue to be studied. These include: the presence of severe respiratory failure, a high risk of developing respiratory distress syndrome, thrombosis and thromboembolic complications, as well as worsening of the course of chronic cardiovascular diseases. All this eventually leads to the development of severe multiple organ failure, which is often the cause of death in this category of patients.

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J-waves in acute COVID-19: A novel disease characteristic and predictor of mortality?

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Background J-waves represent a common finding in routine ECGs (5–6%) and are closely linked to ventricular tachycardias. While arrhythmias and non-specific ECG alterations are a frequent finding in COVID-19, an analysis of J-wave incidence in acute COVID-19 is lacking. Methods A total of 386 patients consecutively, hospitalized due to acute COVID-19 pneumonia were included in this retrospective analysis. Admission ECGs were analyzed, screened for J-waves and correlated to clinical characteristics and 28-day mortality. Results J-waves were present in 12.2% of patients. Factors associated with the presence of J-waves were old age, female sex, a history of stroke and/or heart failure, high CRP levels as well as a high BMI. Mortality rates were significantly higher in patients with J-waves in the admission ECG compared to the non-J-wave cohort (J-wave: 14.9% vs. non-J-wave 3.8%, p = 0.001). After adjusting for confounders using a multivariable cox regression model, the incidence of J-waves was an independent predictor of mortality at 28-days (OR 2.76 95% CI: 1.15–6.63; p = 0.023). J-waves disappeared or declined in 36.4% of COVID-19 survivors with available ECGs for 6–8 months follow-up. Conclusion J-waves are frequently and often transiently found in the admission ECG of patients hospitalized with acute COVID-19. Furthermore, they seem to be an independent predictor of 28-day mortality.

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Renin-angiotensin-aldosterone system in new coronavirus infection 2019

Cited by 9 publications

References 37 publications

Serum biomarkers of cardiovascular complications in COVID-19

Serum biomarkers of cardiovascular complications in COVID-19

Coronavirus Infection an Obese Patient (Literature Review)

J-waves in acute COVID-19: A novel disease characteristic and predictor of mortality?

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