Serum biomarkers of cardiovascular complications in COVID-19

Gumerov, Ruslan M.; Gareeva, Diana; Давтян, П. А.; Rakhimova, R. F.; Musin, Timur Ilgamovich; Загидуллин, Ш. З.; Пушкарева, А. Э.; Плотникова, М. Р.; Ишметов, В. Ш.; Павлов, В. Н.; Мотлох, Л. Я.; Загидуллин, Н. Ш.

doi:10.15829/1560-4071-2021-4456

Cited by 8 publications

(4 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As the Spike protein S of the ACE-2 receptor serves as the binding site for SARS-CoV-2, cells with a high expression of the ACE-2 receptor are primarily affected by COVID-19, resulting in a broad range of clinical symptoms in COVID-19. Several clinical parameters including laboratory, electrocardiographic and radiology findings have been used to stratify mortality risk (1)(2)(3), yet monitoring parameters and long-term prognostic markers for COVID-19 remain scarce.…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular Biomarkers for Prediction of in-hospital and 1-Year Post-discharge Mortality in Patients With COVID-19 Pneumonia

et al. 2022

View full text Add to dashboard Cite

AimsWhile COVID-19 affects the cardiovascular system, the potential clinical impact of cardiovascular biomarkers on predicting outcomes in COVID-19 patients is still unknown. Therefore, to investigate this issue we analyzed the prognostic potential of cardiac biomarkers on in-hospital and long-term post-discharge mortality of patients with COVID-19 pneumonia.MethodsSerum soluble ST2, VCAM-1, and hs-TnI were evaluated upon admission in 280 consecutive patients hospitalized with COVID-19-associated pneumonia in a single, tertiary care center. Patient clinical and laboratory characteristics and the concentration of biomarkers were correlated with in-hospital [Hospital stay: 11 days (10; 14)] and post-discharge all-cause mortality at 1 year follow-up [FU: 354 days (342; 361)].Results11 patients died while hospitalized for COVID-19 (3.9%), and 11 patients died during the 1-year post-discharge follow-up period (n = 11, 4.1%). Using multivariate analysis, VCAM-1 was shown to predict mortality during the hospital period (HR 1.081, CI 95% 1.035;1.129, p = 0.017), but not ST2 or hs-TnI. In contrast, during one-year FU post hospital discharge, ST2 (HR 1.006, 95% CI 1.002;1.009, p < 0.001) and hs-TnI (HR 1.362, 95% CI 1.050;1.766, p = 0.024) predicted mortality, although not VCAM-1.ConclusionIn patients hospitalized with Covid-19 pneumonia, elevated levels of VCAM-1 at admission were associated with in-hospital mortality, while ST2 and hs-TnI might predict post-discharge mortality in long term follow-up.

show abstract

Section: Introductionmentioning

confidence: 99%

Cardiovascular Biomarkers for Prediction of in-hospital and 1-Year Post-discharge Mortality in Patients With COVID-19 Pneumonia

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Метаанализ исследований, проведенный Z.G. Dessie et al (2021), показал повышенный риск смерти от коронавируса у лиц пожилого возраста (относительный риск (ОР) -1,31), среди пациентов мужского пола (ОР -1,24), при ОЖ (OP -1,34), при СД-2 (ОР -1,52), артериальной гипертензии (АГ, ОР -1,57), ХОБЛ (ОР -1,58), ОПП (ОР -1,87), хронической сердечной недостаточности (ХСН) (ОР -2,33), ишемической болезни сердца (ИБС, ОР -1,42), увеличенном содержании Д-димера (ОР -10,49) [7].…”

Section: литератураunclassified

“…Исследование D. Rai et al (2021) демонстрирует повышенную вероятность летального исхода у лиц пожилого возраста (ОР -1,47), старческого возраста (ОР -3,97). Авторы отмечают, что связь ССЗ с летальностью обусловлена возрастными факторами, при которых растет распространенность ССЗ [11].…”

Section: литератураunclassified

“…По сведениям D. Rai et al (2021), выше летальность при следующих показателях: отношение нейтрофилы/лимфоциты > 3,3 (ОР -2,37), ферритин > 322 нг/мл (ОР -2,39), Д-димер > 500 нг/мл (ОР -5,58), мочевина крови > 7,2 мкмоль/л (ОР -3,72), креатинин > 114,9 мкмоль/л (ОР -2,98), альбумин < 34 г/л (ОР -2,30) [11].…”

Section: литератураunclassified

See 1 more Smart Citation

Untitled

2022

Acta med. Eurasica

View full text Add to dashboard Cite

Цель исследования. Изучить корреляционную связь между результатами исследования матки и яичников у здоровых женщин репродуктивного возраста с помощью ультразвуковой эластографии сдвиговой волной с эластометрией и магнитно-резонансной томографии (МРТ) с оценкой измеряемого коэффициента диффузии (ИКД) диффузионно-взвешенных изображений (ДВИ).Материалы и методы. Группа исследования -45 здоровых женщин репродуктивного возраста (средний возраст -32,9±3,1 года). Всем выполнено ультразвуковое исследование с технологией двухмерной эластографии сдвиговой волной с эластометрией (Aixplorer, Supersonic Imagine, Франция) по разработанной и внедренной нами методике. МРТ структур матки и яичников выполнена с использованием протокола ДВИ (магнитно-резонансный томограф Excelart Vantage Atlas, «Toshiba», Япония, 1,5 Тл), оценивались миометрий и слизистая матки в области тела и шейки матки, яичники. В автоматическом режиме в зоне интереса на ADC-картах производился расчет ИКД неизмененных структур тела и шейки матки и придатков. Проводился расчет степени корреляционной связи между результатами ультразвуковой эластографии с эластометрией и магнитно-резонансной томографии с оценкой измеряемого коэффициента диффузии. Результаты. Корреляционный анализ связи показателей жесткости и ИКД структур матки и придатков показал прямую обратную связь между этими значениями и высокую степень тесноты связи по шкале Чеддока (p = 0,000000). При этом большим количественным значениям модуля упругости Юнга (кПа) всех структур матки и яичников соответствовали меньшие значения ИКД (мм 2 /с) аналогичных структур исследуемых органов. Заключение. Полученные данные позволяют оптимизировать диагностический алгоритм и дополнить стандартные протоколы ультразвуковых и магнитно-резонансно-томографических исследований гинекологических органов с использованием двухмерной эластографии сдвиговой волной с эластометрией и магнитно-резонансной томографии с оценкой измеряемого коэффициента диффузии диффузионно-взвешенных изображений.

show abstract

Assessment of echocardiographic indicators of electric train drivers who have been ill with a new coronavirus infection

Gerasimidi,

Glukhov

2024

Med. tr. prom. èkol.

View full text Add to dashboard Cite

Introduction. The pandemic of a new coronavirus infection has become an emergency of international importance due to the high risk of developing life-threatening conditions and complications. Long-term cardiovascular outcomes after COVID-19 remain poorly understood, especially among professional groups, including those related to transport management, which account for a large number of people. Employees of locomotive crews in the course of their professional activities work under the influence of various factors of the industrial environment (noise, vibration), occupational stress (shift work, violation of work and rest, monotony of work) and also non-productive factors: smoking, increased body weight, high blood pressure, which affect the development of cardiovascular diseases, and coronavirus infection can worsen cardiovascular complications. Currently, the use of echocardiography allows timely detection of structural and functional disorders of the heart, which helps both in the early and late postinfection period. The study aims to evaluate echocardiographic indicators in locomotive crew workers who had suffered a coronavirus infection, depending on the severity of the course and the presence of non–occupational risk factors for the development of cardiovascular diseases. Materials and methods. The study included 20 male employees of locomotive crews, aged 44.7±6.4 years, who suffered COVID-19 in the first and second quarters of 2022, and are currently continuing their work. The research was conducted in the period 2022–2023. Depending on the severity of the coronavirus infection and non-professional risk factors, the researchers divided the workers into 2 groups: the 1st group consisted of workers who had suffered a severe form of COVID-19 and had risk factors: smoking, increased body weight, high blood pressure; the 2nd group consisted of workers who had suffered a mild form of COVID-19 without non-occupational risk factors. Employees underwent echocardiography with Doppler examination, measurement of blood pressure and heart rate every three months, for a year, after the closure of the employee disability sheet. Archival studies of echocardiography, blood pressure and heart rate measurements performed before COVID-19 disease were taken from outpatient records. Results. Experts have identified in workers of group 1 (severe form), with existing non-occupational risk factors for the development of cardiovascular diseases (smoking, increased body weight, high blood pressure), in contrast to echocardiography indicators of group 2, signs of remodeling of the left ventricular myocardium, due to a slight increase in the linear size of the heart (thickness of the interventricular septa in the diastole, final diastolic size) with preserved systolic function of the left ventricle, ejection fraction of more than 60% (according to the Teicholz method), but with impaired relaxation of the left ventricular myocardium (E/A<1, DT>240 ms, IVRT>90 ms). When comparing systolic blood pressure and heart rate, the authors noted an increase in both groups. In workers who have suffered a severe form of coronavirus infection, blood pressure indicators correspond to "grade I hypertension" and require the appointment of antihypertensive therapy on an ongoing basis. In group 2 workers, blood pressure indicators correspond to "high normal blood pressure" and do not require the appointment of regular antihypertensive therapy. Limitation. The limitation of the study is the small number of observations of employees of locomotive crews currently working and who have had a coronavirus infection. Conclusion. Structural and functional changes in the heart of locomotive crew workers who have had coronavirus infection and are currently working are associated with the severity of COVID-19 and the presence of risk factors (high blood pressure, smoking, overweight). In the mild form of coronavirus infection in workers, the authors revealed functional changes – an increase in heart rate and blood pressure to the level of "high normal blood pressure", in the severe form functional (increased heart rate, blood pressure, impaired relaxation of the left ventricle) and structural (initial manifestations of left ventricular myocardial remodeling). Employees of both groups who have suffered both severe and mild forms of coronavirus infection are currently continuing their work as an "electric train driver" and currently need the supervision of therapeutic and diagnostic specialists. Ethics. This study was approved by the local Ethics Committee of the Izmerov Research Institute of Occupational Health (extract from Protocol No. 1 dated February 16, 2022).

show abstract

Serum biomarkers of cardiovascular complications in COVID-19

Cited by 8 publications

References 45 publications

Cardiovascular Biomarkers for Prediction of in-hospital and 1-Year Post-discharge Mortality in Patients With COVID-19 Pneumonia

Cardiovascular Biomarkers for Prediction of in-hospital and 1-Year Post-discharge Mortality in Patients With COVID-19 Pneumonia

Untitled

Assessment of echocardiographic indicators of electric train drivers who have been ill with a new coronavirus infection

Contact Info

Product

Resources

About