Renin-angiotensin-aldosterone system gene polymorphisms in coronary artery bypass graft surgery patients

Ragia, Georgia; Nikolaidis, Eleftherios; Tavridou, Anna; Arvanitidis, Konstantinos; Kanoni, Stavroula; Dedoussis, George; Bougioukas, Georgios; Manolopoulos, Vangelis G.

doi:10.1177/1470320310361742

Cited by 15 publications

(11 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar data were obtained by Renner et al, who reported no association of two AGT polymorphisms (rs699 and rs4762) with blood pressure and CAD in German population (Renner et al, 2005). On the other hand, two AGT polymorphisms studied by Ragia et al, were not associated with CAD and coronary artery bypass grafting in Greek population (Ragia et al, 2010). In contrast to these results, Al-Najai et al, reported that the rs5051, and rs699 polymorphisms were associated with risk of developing myocardial infarction in native Saudi population (Al-Najai et al, 2013).…”

Section: Discussionsupporting

confidence: 84%

“…Polymorphisms in the genes that encode these molecules have been associated with risk of developing inflammatory diseases, such hypertension, atherosclerosis, vascular disease, coronary artery disease, blood pressure, coronary artery bypass graft, preeclampsia, and acute pancreatitis (Mansego et al, 2008;Ragia et al, 2010;Dzielinska et al, 2011;Abd El-Aziz et al, 2012;Al-Najai et al, 2013;Brugts et al, 2011;Wang et al, 2014;Skipworth et al, 2015;Mirsha et al, 2012). In the present work, we studied seven polymorphisms, five located in the AGT gene and two located in the REN gene.…”

Section: Discussionmentioning

confidence: 89%

“…On the other hand, the angiotensinogen is a key Experimental and Molecular Pathology 99 (2015) 128-132 component of RAS, it is cleaved by renin to produce angiotensin I. AGT gene presents five important single nucleotide polymorphisms (SNPs), three in the promoter region [− 6 ANG (rs5051), − 217 GNA (rs5049) and − 532 CNT (rs5046)] and two in the exon 2 [C4072T (rs699) and C3889T (rs4762)]. These SNPs have been associated with risk of developing hypertension, acute myocardial infarction, vascular disease, coronary artery disease, atherosclerosis, and coronary artery bypass graft in several populations (Inoue et al, 1997;Karayannis et al, 2010;Ragia et al, 2010;Mehri et al, 2011;Dzielinska et al, 2011;Abd El-Aziz et al, 2012;Al-Najai et al, 2013;Brugts et al, 2011). On the other hand, the REN gen presents two relevant SNPs, one in the intron 4 [G5795T (rs5707)] and one in the exon 2 [C4280A (rs5705)].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The C4280A (rs5705) gene polymorphism of the renin (REN) gene is associated with risk of developing coronary artery disease, but not with restenosis after coronary stenting

Fragoso

Álvarez-León

Delgadillo-Rodríguez

et al. 2015

Experimental and Molecular Pathology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The C4280A (rs5705) gene polymorphism of the renin (REN) gene is associated with risk of developing coronary artery disease, but not with restenosis after coronary stenting

Fragoso

Álvarez-León

Delgadillo-Rodríguez

et al. 2015

Experimental and Molecular Pathology

View full text Add to dashboard Cite

“…By virtue of the function of AGT in regulating blood pressure, changes in its gene sequence are likely to play an important role in the pathogenesis of cardiovascular risk traits, such as hypertension, as well as manifestation of coronary artery disease (CAD) [2,3]. Several AGT variants, including the rs4762 (p.M207T, also formerly known as p.T174M) and rs699 (p.M268T, also referred to as p.M235T), have been associated with susceptibility to various cardiovascular risk traits, such as primary hypertension (HTN) [4-10] and type 2 diabetes (T2DM) [11,12], that are linked to the development of CAD. These variants have similarly been implicated not only in the manifestation of CAD [13-23], but also in the severity of atherosclerosis [24,25].…”

Section: Introductionmentioning

confidence: 99%

Association of the angiotensinogen gene polymorphism with atherosclerosis and its risk traits in the Saudi population

Al-Najai

Muiya

Tahir

et al. 2013

BMC Cardiovasc Disord

View full text Add to dashboard Cite

BackgroundAngiotensinogen (AGT) constitutes a central component of the renin-angiotensin system that controls the systemic blood pressure and several other cardiovascular functions and may play an important role in atherosclerosis pathways. In this study, we employed TaqMan genotyping assays to evaluate the role of 8 AGT variants in primary hypertension (HTN), type 2 diabetes mellitus (T2DM), and obesity as a possible trigger of coronary artery disease (CAD) in a population of 4615 angiographed native Saudi individuals.MethodsLinkage analysis was done by using the Affymetrix Gene Chip array, sequencing by using the MegaBACE DNA analysis system and genotyping accomplished by TaqMan chemistry using the Applied Biosystem real-time Prism 7900HT Sequence Detection System.ResultsSix variants, rs2067853 GG [Odds ratio(95% Confidence Interval) = 1.44(1.17-1.78); p = 0.001], rs7079 [1.49(1.20-1.85); p < 0.0001], rs699 G [1.19(1.08-1.13); p < 0.0001], rs3789679 A [1.51(1.14-1.99); p = 0.004], rs2148582 GG [1.31(1.11-1.55); p = 0.002] and rs5051 TC + CC [1.32(1.13-1.60); p = 0.001] conferred risk for HTN (3521 cases versus 1094 controls). The rs2067853 (p = 0.042), rs699G (p = 0.007) and rs5051 (p = 0.051) also conferred risk for myocardial infarction (MI; 2982 vs 1633), while rs3789679 A (p < 0.0001) and GA + AA (p < 0.0001) as well as rs4762G (p = 0.019) were associated with obesity (1576 vs 2458). However, while these variants appeared to be also associated with CAD (2323 vs 2292), only the rs7079G (p = 0.035) retained its significant relationship. Interestingly, among the haplotypes constructed from these SNPs, the baseline 8-mer haplotype, GGTGGGGT (χ2 = 7.02; p = 0.0081) and another GGCGGAGT (χ2 = 5.10; p = 0.024), together with several of their derivatives were associated with HTN. T2DM was associated with two 8-mer haplotypes, GGTAGGAC (χ2 = 5.66; p = 0.017) and ATTGAGAC (χ2 = 5.93; p = 0.015), obesity with GGCGGAGT (χ2 = 9.49; p = 0.0021) and MI was linked to ATTGGGAC (χ2 = 6.68; p = 0.010) and GGTGGGAT (χ2 = 4.25; p = 0.039). Furthermore, several causative haplotypes were also shared among the risk traits as well as with CAD.ConclusionThese results point to AGT as independently conferring risk for various cardiovascular traits, and possibly interacting with these traits in events leading to atherosclerosis.

show abstract

“…(Procopciuc et al, 2002). et al, 2003) 109/86 M F Turkia HE TT (Araujo et al, 2005) 201/104 M F Brasil DAC e IM NS (Fardella et al, 1998) 64/62 M F Chile PS TT (Fatini et al, 2000) 205/209 M F Itália DAC NS (Glavnik ePetrovic, 2007) 413/404 M F Eslovênia HE NS a (Lanz et al, 2005) 871 M F Brasil DAC b TT e T (Mondorf et al, 1998) 121/125 M F Alemanha HE NS (Mondry et al, 2005) 638/720 M F Alemanha HE TT c (Procopciuc et al, 2002) 38/21 M F Romênia HE TT e T (Ragia et al, 2010) 154/155 M F Grécia DAC NS (Ragia et al, 2010) 154/155 M F Grécia HE TT (Rodriguez-Perez et al, 2001) 304/315 M F Espanha DAC TT (Say et al, 2005) posição 235 (M235T) e foi significantemente associado com o risco de hipertensão (Niu et al, 1999)…”

Section: Aspectos Genéticos Da Hipertensãounclassified

Polimorfismos genéticos do sistema renina-angiotensina-aldosterona na doença arterial coronariana e na hipertensão arterial sistêmica

Bonfim-Silva¹

2012

RUVRV

View full text Add to dashboard Cite

Palavras-chave: hipertensão. doença arterial coronariana. enzima conversora da angiotensina. angiotensinogênio. polimorfismos. Genetic polymorphisms of the renin-angiotensin-aldosterone on coronary arterial disease and systemic arterial hypertension ABSTRACT: Hypertension is considered a risk factor for coronary artery disease (CAD). Hypertension and atherosclerosis are the two major diseases of the arterial system and are closely associated. The renin-angiotensinaldosterone system (RAAS) has been identified as a critical path for the control of blood pressure and kidney function. This system has an important role in regulating blood pressure by influencing homeostasis salt / water and therefore having an intimate relationship with the process of hypertension. Since hypertension emerges as a risk factor for CAD, the RAAS is also related to this disease. Most human diseases are polygenic and multifactorial, they are governed by many genes and caused by a combination of factors acting together and simultaneously. Due to the strong relationship already mentioned between RAAS and hypertension and CAD, polymorphisms in candidate genes of this system, as well as polymorphisms in the angiotensin converting enzyme gene (ACE) and angiotensinogen gene (AGT) have been analyzed extensible as genetics determinants of these diseases. Studies of genetic polymorphisms have several functions, among them the determination of molecular markers linked to disease development. This becomes important because the development of molecular markers may lead to a new prognosis. In the case of CAD and hypertension, changes in the RAAS are closely related to the occurrence of these diseases, and consequently polymorphisms in genes that control this system can direct us to understand how the genetic influences the development of these diseases.

show abstract

Renin-angiotensin-aldosterone system gene polymorphisms in coronary artery bypass graft surgery patients

Abstract: There is no association of the analysed RAAS polymorphisms with severe CAD in CABG patients. However, within these patients, an association was found between AGT 235TT genotype and hypertension.

Cited by 15 publications

References 46 publications

The C4280A (rs5705) gene polymorphism of the renin (REN) gene is associated with risk of developing coronary artery disease, but not with restenosis after coronary stenting

The C4280A (rs5705) gene polymorphism of the renin (REN) gene is associated with risk of developing coronary artery disease, but not with restenosis after coronary stenting

Association of the angiotensinogen gene polymorphism with atherosclerosis and its risk traits in the Saudi population

Polimorfismos genéticos do sistema renina-angiotensina-aldosterona na doença arterial coronariana e na hipertensão arterial sistêmica

Contact Info

Product

Resources

About