Renin and atrial natriuretic peptide restriction fragment length polymorphisms: association with ethnicity and blood pressure

Strong association of the renin TaqI polymorphism with essential hypertension in Chinese Han and Tibetan populations

“…The distributions of TaqI polymorphism have varied greatly among different reports. In our study, the frequency of TaqI t allele in Han population (9.7%) was almost similar to that of Tibetan population (10.0%), which was lower than that in Caucasian European population 9 (13.7%) and in Danmark population 4 (14.6%), and also was exceedingly lower than that in Afro-Caribbean population 9 (28.4%). These discrepancies might be due to differences among ethnic populations and differences in sampling methods.…”

Haplotypes of the human renin gene associated with essential hypertension and stroke

“…[1][2][3][4][5][6] It is thus of particular appeal in investigations aimed at identifying QTLs implicated in EHT and allied clinical manifestations. So far, however, both positive associations with EHT, family history of EHT and intermediate phenotypes [10][11][12][18][19][20][21][22][23] and negative results as for association or linkage studies with EHT [24][25][26][27][28][29][30][31][32][33][34][35][36] have been reported.…”

Why is plasma renin activity lower in populations of African origin?

“…But any effects are likely to be small as a lower PRA in blacks was also associated with a lower plasma concentration of renin. 28 A number of polymorphic variants have recently been identified within the renin gene raising the possibility that these variants might influence renin activity, 29 however, as yet, there is no evidence that these are associated with differences in plasma renin activity, in whites at least. 30 Several polymorphic variants have also been identified within the angiotensinogen gene; some of these polymorphisms (eg the M235T polymorphism) are associated with increased levels of plasma angiotensinogen, and therefore could lead to increased PRA.…”