Renin and angiotensin. A survey of some aspects

Brown, J. J.; Lever, A. F.; Davies, D. L.; Robertson, J. I. S.

doi:10.1136/pgmj.42.485.153

Cited by 116 publications

(27 citation statements)

References 162 publications

(106 reference statements)

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“…These observations do not exclude the possibility that hyponatra emia is a stimulus to an increase o f plasma renin concentration although earlier experiments show that if renin is stimulated in this way, the effect can be overcome by other factors [11]. Furthermore, in our patient, plasma renin concentration increased during a dialysis in which plasma sodium concentration also rose.…”

Section: Hyponatraemia In Hypertensionmentioning

confidence: 52%

“…Beyond this, no further characterisation of the plasma material was attempted, although the more extensive stu dies of C a p e l li et al [17] suggest that the plasma material is in fact renin. Duplicate estimates of the concentration of renin-like enzyme in the plasma of an anephric woman using the slightly different tech niques of B row n et al [8] and C a p e l li et al [17] showed close agree ment [17], Enzymes indistinguishable from renin have been extracted from the salivary and adrenal glands and from the placenta, uterus and amniodc fluid [11,47,48], Renin may therefore be produced in these extrarenal sites and liberated into blood. Studies of the effect of nephrectomy suggest that the contribution from these extrarenal sources is normally small relative to that made by the kidney.…”

Section: Changes Of Renin Following Bilateral Nephrectomymentioning

confidence: 99%

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Plasma Renin Concentration and the Control of Blood Pressure in Patients on Maintenance Haemodialysis

Brown

Curtis

Lever

et al. 1969

Nephron

125

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Plasma renin concentration was measured in 19 patients undergoing maintenance haemodialysis for chronic renal failure. The highest plasma renin concentrations were found in the two patients in whom bilateral nephrectomy was necessary to control blood pressure. Normal or moderately raised renin values were found in the remaining patients in whom blood pressure was more readily controlled. Bilateral nephrectomy reduced plasma renin concentration in each of 6 patients, although renin-like activity did not disappear from blood in the months following the operation. Marked loss of weight during dialysis increased plasma renin concentration whereas lesser reduction in weight usually produced a fall in plasma renin concentration.

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Section: Hyponatraemia In Hypertensionmentioning

confidence: 52%

Section: Changes Of Renin Following Bilateral Nephrectomymentioning

confidence: 99%

Plasma Renin Concentration and the Control of Blood Pressure in Patients on Maintenance Haemodialysis

Brown

Curtis

Lever

et al. 1969

Nephron

125

View full text Add to dashboard Cite

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“…The octapeptide, angiotensinII, is made by the action of another enzyme (converting enzyme) on this decapeptide; all the pharmacological activity of the renin-angiotensin system resides in the octapeptide angiotensinII. The control of the system, which is probably through changes in secretion of renin, has been studied for many years (see Peart, 1965;Brown, Davies, Lever & Robertson, 1966;Vander, 1967). For example, a fall of renal arterial pressure rapidly induces secretion of renin (Skinner, McCubbin & Page, 1963;Regoli & Vane, 1966).…”

Section: Peptides (A) Br-advkininimentioning

confidence: 99%

The release and fate of vaso‐active hormones in the circulation

Vane

1969

British J Pharmacology

641

248

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“…Massani et al (28) also reported high levels of plasma renin in patients with congestive heart failure, but there was a wide scatter in their data, and considerable overlap occurred between normal and experimental values. In a review Brown, Davies, Lever, and Robertson (29) stated that two distinct patterns have been observed in untreated congestive failure; the plasma renin was low and increased with diuretic therapy, or renin was high and fell with treatment. In the present study plasma renin was elevated in experimental heart failure (both low and high output) in all but two dogs with high output failure.…”

Section: Figurementioning

confidence: 99%

Plasma Renin in Chronic Experimental Heart Failure and during Renal Sodium "Escape" from Mineralocorticoids

Johnston

Davis

Robb

et al. 1968

Circulation Research

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A striking increase in the plasma renin level occurred in dogs with low output right heart failure secondary to tricuspid insufficiency and pulmonic stenosis and in three of five animals with high output failure produced by a large arteriovenous fistula. When dogs with a small arteriovenous fistula were given daily injections of DOCA, the renal sodium "escape" phenomenon occurred. In these animals, the level of plasma renin was suppressed during DOCA administration both during the initial period of sodium retention and also later when sodium balance was normal or negative. In contrast, when dogs with a larger arteriovenous fistula but without evidence of cardiac failure were given DOCA, they retained sodium and developed signs of congestive heart failure. However, in these animals with congestion and ascites, in contrast to-the dogs that developed spontaneous high output failure, the plasma renin was low. Renin-substrate was unaltered in all of the experimental situations studied except for the decrease observed in dogs with low output right heart failure, la these animals, it seems likely that decreased renin-substrate was secondary to hepatic congestion and liver damage. The renin-angiotensin system does not seem to be related to the "escape" phenomenon, and renin does not appear to be the factor that makes the kidney unusually responsive to mineralocorticoids. Thus, in experimental heart failure the reninangiotensin system was activated, but in the congestive syndrome produced by DOCA the plasma renin level was suppressed. ADDITIONAL KEY WORDSrenin-angiotensin system arteriovenous fistula desoxycorticosterone sodium balance renin-substrate tricuspid insufficiency and pulmonic stenosis high output failure conscious dogs• Hypersecretion of aldosterone is common in edematous states (1-12). Many patients with congestive heart failure have increased secretion and excretion of aldosterone (1, 3-7), but patients with edema also have normal rates of secretion, of this hormone (8-10). Experimental heart failure in dogs is regularly accompanied by an increase in aldosteroneFrom the Departments of Physiology and Surgery, University of Missouri School of Medicine, Columbia, Missouri 6520X.This investigation was supported in part by U. S. Public Health Service Research Grant HE 10612-01 from the National Heart Institute.Dr. Johnston is Research Fellow, National Heart Foundation of Australia.Accepted for publication December 10, 1967. secretion and a high plasma level of aldosterone (2,11,12). The increase in plasma aldosterone in heart failure also results from a decrease in the metabolic clearance of aldosterone by the Ever (4, 9, 13). The present study relates the participation of the reninangiotensin system in experimental heart failure to sodium balance and to the known hypersecfetion of aldosterone. This investigation is also concerned with the role of the renin-angiotensin system in the "escape" phenomenon (14-15). Normal humans or animals given large quantities of a mineralocorticoid retain sodium for only ...

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Renin and angiotensin. A survey of some aspects

Cited by 116 publications

References 162 publications

Plasma Renin Concentration and the Control of Blood Pressure in Patients on Maintenance Haemodialysis

Plasma Renin Concentration and the Control of Blood Pressure in Patients on Maintenance Haemodialysis

The release and fate of vaso‐active hormones in the circulation

Plasma Renin in Chronic Experimental Heart Failure and during Renal Sodium "Escape" from Mineralocorticoids

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