Renal Vein Renin Activity and Prostaglandins A and E in Hypertension

Abstract

The relation between renal vein renin activity (RVRA) and renal vein prostaglandin A (PGA) and prostaglandin E (PGE) concentrations was examined in 50 patients with hypertension who underwent renal vein catheterizations for suspected renovascular hypertension. In 14 patients with unilateral renal artery stenosis, mean renal vein PGE concentrations were higher in the renal vein draining the nonischemic kidney, while RVRA was increased in the renal vein draining the ischemic kidney. PGE ratios from the two sides were inversely related to RVRA ratios in this group. In the other 36 patients with either bilateral renal artery stenosis, essential hypertension or nonrenovascular unilateral renal disease, RVRA and PGE concentrations were similar in both kidneys. No relation between RVRA and PGA could be established for any group.

Role of Sodium and Renal Prostaglandin E₂ in the Maintenance of Hypertension in the Chronic Phase of Two-Kidney One-Clip Renovascular Hypertension in Rabbits

“…However, in the present study UPGE2V of the clipped kidney was significantly lower than the control value. The same re sults were also reported in human RVH [16,17], Since ischemia in the clipped kidney is reduced by a high perfusion pressure during progress of hypertension [23] and PRA in this experiment was at a low level, renal PGE2 synthesis might not be stimulated so highly as that in the early phase. On the other hand, renal PGs production in the nonclipped kidney was reported to increase in the early phase which might be mediated by circulating an giotensin II stimulation [2,[13][14][15][16][17][18]20,21].…”