Renal ultrastructure, renal function, and parameters of lead toxicity in workers with different periods of lead exposure

Cramér, Kim; Goyer, Robert A.; Jagenburg, Rudolf; Wilson, Marion H.

doi:10.1136/oem.31.2.113

Cited by 65 publications

(50 citation statements)

References 30 publications

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“…Two studies reported only on young children (Ͻ10 years), 25,37 two studies were case reports, 45,48 one 66 recruited less than 50 persons, in one 54 owing to missing information the analysis was performed in less than 50 subjects, five estimated exposure from other measurements than the blood lead concentration, 30,77,78,81,88 and 11 did not provide enough information to compute the association size. 17,19,22,26,27,36,39,62,63,67,86 …”

Section: Selection Of Studiesmentioning

confidence: 99%

An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis

et al. 2002

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Studies on the possible association between blood pressure and blood lead have reached divergent conclusions. In a previous meta-analysis, a doubling of the blood lead concentration was associated with a 1.0/0.6 mm Hg increase in systolic and diastolic blood pressure (BP). This meta-analysis updates the analysis originally performed in 1994. Articles on the association between BP and blood lead were identified from computer searches from January 1980 to February 2001 using the Medical Literature Analysis and Retrieval System. Of the studies reviewed, 31 provided sufficient details to be considered. The meta-analysis included 58 518 subjects recruited from the general population in 19 surveys and from occupationally exposed groups in 12 studies. In all but four studies, the results were adjusted for age, and

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Section: Selection Of Studiesmentioning

confidence: 99%

An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis

et al. 2002

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“…Renal effects in man have been described in clinical reports (21,24,35), by studies of renal function (14,23,33,38,47), and by epidemiologic studies. For example, Lane (19,20) Because, as Lane (19) pointed out, animals exposed to lead have shown both tubular and vascular changes in the kidneys, it is of interest that in our study there were excess deaths in both the chronic nephritis and the renal vascular disease categories.…”

Section: Chronic Renal Diseasementioning

confidence: 99%

Mortality among employees of lead battery plants and lead-producing plants, 1947-1980.

Cooper¹,

Wong²,

Kheifets³

1985

Scand J Work Environ Health

121

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Mortality among employees of lead battery plants and lead-producing plants, . Scand J Work En viron Health II (1985) 331-345. Two cohorts of male lead workers, 4 519 battery plant workers and 2 300 lead production workers, all of whom had been employed for at least one year during the period I January 1946 through 31 December 1970, were observed for mortality during the 34 years from 1 Januar y 1947 through 31 December 1980. Vital status as of the closing date was determined for 94.7 lifo of the former group and 91.6 lifo of the latter. There were 1 718 deaths in the first cohort and 621 in the second. Mortality from all causes combined was significantly greater than expected in each cohort, the standardized mortality ratio (SMR) being 107 and 113, respectively. Among the battery plant workers the greater than expected mortality rate resulted in large part from a significant number of excess deaths from malignant neoplasms (SMR 113), other hypertensive disease (mainly renal) (SMR 320), chronic nephritis (SMR 222), and a group of ill-defined conditions (SMR 355). Among the lead production workers the pattern was similar, with a significant number of excess deaths from other hypertensive disease (SMR 475), hypertensive heart disease (SMR 203), chronic nephritis (SMR 265), and ill-defined conditions (SMR 214). There was also a significant excess of deaths from external causes (SMR 143). The SMR for total malignancies was 113, but this value was not significantly elevated at the 5 % level. In neither cohort were deaths from cerebrovascular disease in significant excess, the SMR being 93 and 132, respectively. A proport ionate mortality analysis showed that the excess deaths from cerebrovascular diseaseand from hypertensive heart disease among smelter workers were in part due to the high proportion of nonwhites in the smelter populations. The stomach, liver, and lungs were the sites responsible for most excess cancer deaths in both cohorts, but the elevated SMR values were statistically significant only for gastric and lung cancers in battery plant workers. There were no excess deaths from malignancies of the kidney, brain, or Iymphopoeitic system in either cohort. It is impossible to relate the observed mortality to levels of lead exposure; because of meager quantit ative information prior to 1960. It is known that past exposures had been very high. Ethnicity, diet, alcohol, and cigarette smoking could not be ruled out as possibleconfounding etiologic factors for the cancer deaths.

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“…In animal experiments, Goyer et al11,12) described intranuclear inclusion bodies induced by lead. Cramer et al 13) reported the pathological findings of intranuclear inclusion bodies in lead exposed workers.…”

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confidence: 99%

Renal Dysfunction Indicators in Lead Exposed Workers

Jung

Lee

Kim

et al. 1998

Journal of Occupational Health

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Abstract:Real Dysfunction Indicators in Lead Exposed Workers: Kap-Yeol JUNG, et al. Department of Preventive Medicine and Industrial Medicine Research Institute, Dong-A University School of Medicine-This study was undertaken to find out which indicators were most valuable as markers of renal dysfunction related to lead exposure. We selected 75 male workers from the secondary lead smelter, plastic stabilizer and radiator manufacturing industries (the "exposed" group) and 64 male office workers (the "control" group) . Blood lead, blood zinc protoporphyrin, urine lead, urine coproporphyrin, 3-aminolevulinic acid dehydratase activity, and urine 8-aminolevulinic acid were chosen as indicators of lead exposure. Blood urea nitrogen, serum creatinine, serum uric acid, urine N-acetyl-p-D-glucosaminidase, urine albumin, urine a,-microglobulin and urine fl2-microglobulin were used as indicators of renal dysfunction.The urine a,-microglobulin level was significantly associated with the lead exposure level. Blood urea nitrogen, urine Nacetyl-p-D-glucosaminidase and urine a1-microglobulin levels were highly correlated with indicators of lead exposure. Urine a,-microglobulin had the highest correlation with other indicators of renal function. Conclusively, blood urea nitrogen, urine N-acetyl-fl-Dglucosaminidase and urine a,-microglobulin are useful indicators, but urine a,-microglobulin is the earliest and the most valuable indicator of renal dysfunction due to lead exposure. (J Occup Health 1998; 40: 103-109)

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Renal ultrastructure, renal function, and parameters of lead toxicity in workers with different periods of lead exposure

Cited by 65 publications

References 30 publications

An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis

An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis

Mortality among employees of lead battery plants and lead-producing plants, 1947-1980.

Renal Dysfunction Indicators in Lead Exposed Workers

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