Renal Tubulocystic Carcinoma Is Closely Related to Papillary Renal Cell Carcinoma: Implications for Pathologic Classification

Zhou, Ming; Yang, Ximing J.; López, José I.; Shah, Rajal B.; Hes, Ondřej; Shen, Steven S.; Li, Rongshan; Yang, Yu; Lin, Fan; Elson, Paul; Sercia, Linda; Magi‐Galluzzi, Cristina; Rr, Tubbs

doi:10.1097/pas.0b013e3181be22d1

Cited by 119 publications

(102 citation statements)

References 20 publications

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“…61 Some studies suggest a relationship between tubulocystic and papillary carcinoma. 59,62 Indeed, in one study tubulocystic carcinoma was commonly associated with papillary carcinoma, with both tumors showing gains in chromosomes 7 and 17. 62 The histogenesis of tubulocystic carcinoma is unclear.…”

Section: Tubulocystic Carcinomamentioning

confidence: 99%

“…59,62 Indeed, in one study tubulocystic carcinoma was commonly associated with papillary carcinoma, with both tumors showing gains in chromosomes 7 and 17. 62 The histogenesis of tubulocystic carcinoma is unclear. The marker studies and electron microscopic observations indicate that the tumor cells express aberrant tubular differentiation.…”

Section: Tubulocystic Carcinomamentioning

confidence: 99%

“…Sometimes tubulocystic and papillary renal cell carcinoma are found separately in the kidney and at other times they are closely admixed. 59,62 The relationship between tubulocystic and papillary renal cell carcinoma, along with the overlapping immunohistochemical and molecular patterns, suggest a taxonomic relationship. We would argue that tubulocystic carcinoma is a subset of papillary renal cell carcinoma, just as multiloculated clear cell renal cell carcinoma is considered a variant of clear cell renal cell carcinoma.…”

Section: Tubulocystic Carcinomamentioning

confidence: 99%

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Uncommon and recently described renal carcinomas

2009

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Major consensus conferences held over a decade ago laid the foundations for the current (2004) WHO classification of renal carcinoma. Clear cell, papillary and chromophobe carcinomas account for 85-90% carcinomas seen in routine practice. The remaining 10-15% of carcinomas consist of rare sporadic and hereditary tumors, some of which had been long recognized, but many of which only emerged as distinct entities in the decade leading up to the WHO publication. Collecting-duct carcinoma is a rare, often lethal form of carcinoma. Medullary carcinoma associated with sickle cell trait, has emerged as a distinctive tumor showing some overlapping features with upper tract urothelial carcinoma. Mucinous tubular and spindle-cell carcinoma and tubulocystic carcinoma were earlier considered as patterns of low-grade collecting-duct carcinoma, but are now recognized as separate tumor entities. Carcinomas associated with somatic translocations of TFE3 and TFEB comprise a significant proportion of pediatric renal carcinomas. Oncocytoid renal carcinomas in neuroblastoma survivors was recognized as a unique tumor category in the WHO classification. Renal carcinoma associated with end-stage renal disease is now recognized as having distinct morphological patterns and behavior. In addition there is a group of rare recently described carcinomas, including clear cell papillary carcinoma, oncocytic papillary renal cell carcinoma, follicular renal carcinoma and leiomyomatous renal cell carcinoma. It behooves the surgical pathologist to not only be capable of diagnosing the common forms of renal cancer, but also to be aware of the rare types of renal carcinoma, many of which have emerged in recent years.

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Section: Tubulocystic Carcinomamentioning

confidence: 99%

Section: Tubulocystic Carcinomamentioning

confidence: 99%

Section: Tubulocystic Carcinomamentioning

confidence: 99%

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Uncommon and recently described renal carcinomas

2009

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“…In den letzten Jahren wurden verschiedene Fallberichte über das so genannte tubulozystische Nierenzellkarzinom veröffentlicht [10,11] …”

Section: Tubulozystisches Nierenzellkarzinomunclassified

Cystic renal neoplasms

Moch¹

2010

Pathologe

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“…The relationship of these tumors to collecting duct carcinoma and papillary RCC remains controversial. [47][48][49] In our experience, areas sharing histologic features with tubulocystic carcinoma can occasionally be seen in otherwise typical collecting duct carcinoma.…”

Section: Cystic Nephroma and Mixed Epithelial And Stromal Tumormentioning

confidence: 99%

Spectrum of Preneoplastic and Neoplastic Cystic Lesions of the Kidney

Chen¹,

Tickoo²

2012

Archives of Pathology &Amp; Laboratory Medicine

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Context.—Cystic lesions of the kidney may be accompanied by a range of neoplasms with distinct prognoses and future risks of developing additional tumors. In addition, some renal tumors, with or without accompanying renal cysts, may show a prominent cystic component. In the adult population, neoplasms occurring in a background of renal cystic diseases and cystic renal neoplasms often pose diagnostic challenges because of their many overlapping features. Objective.—To review the clinicopathologic characteristics of common entities in the spectrum of neoplastic and potential preneoplastic cystic lesions encountered in adults, with an emphasis on renal cystic diseases associated with tumor development and on renal neoplasms with predominantly cystic morphology. Data Sources.—The relevant English-language literature was reviewed, accompanied by the authors' experience at their practicing institution. Conclusions.—The presence of multiple renal cysts, both acquired and syndromic, can be associated with a variety of renal tumors. The morphology of the cysts and associated tumor types can help predict the genetic or acquired basis of the lesions, and particularly in specimens with no accompanying pertinent clinical history, such potential associations should be suggested in surgical pathology reports.

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Renal Tubulocystic Carcinoma Is Closely Related to Papillary Renal Cell Carcinoma: Implications for Pathologic Classification

Cited by 119 publications

References 20 publications

Uncommon and recently described renal carcinomas

Uncommon and recently described renal carcinomas

Cystic renal neoplasms

Spectrum of Preneoplastic and Neoplastic Cystic Lesions of the Kidney

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