Renal tubular dysgenesis associated with in utero exposure to Nimuselide

Abstract

Maternal ingestion of the selective cyclo-oxygenase-2 (COX-2) inhibitor Nimuselide has been reported to be associated with the development of oligohydramnios and neonatal renal failure in some cases. We report a case of neonatal renal failure associated with maternal ingestion of Nimuselide in the third trimester of pregnancy. The neonate presented with metabolic acidosis and non-oliguric renal failure on the second day of life. The renal histopathology showed evidence of renal tubular dysgenesis. The child continues to have elevated serum creatinine and hypertension at 10 months of age.

Maternal ingestion of diclofenac leading to renal failure in newborns

“…Ali et al recognized the causal role of nimesulide in neonatal renal failure and renal tubular dysgenesis following in utero exposure to the drug [12]. Landau et al reported perinatal vasoconstrictive renal insufficiency associated with maternal nimesulide use [13].…”

Nimesulide controversy: A comparison of EU and Indian scenario

“…There are 24 publications on ADR, 10 case reports and 14 case series from India. Case reports do provide signals on, for example, information on neonatal kidney failure due to exposure to nimesulide during pregnancy and are important [17,18]. There are two case series from a single centre on drug induced liver injury.…”

Diets and Circadian Rhythms: Challenges from Biology for Medicine

“…Capone et al (2005) argue that coxibs are appropriate for patients at low cardiovascular risk only, while granting that they increase the risk of gastrointestinal complaints. Coxibs at times cause nephritis, and kidney failure as well (Cheng and Harris, 2005;Esteve et al, 2005;Ali et al, 2006). The findings of Ali et al (2006) are especially disturbing.…”

“…Coxibs at times cause nephritis, and kidney failure as well (Cheng and Harris, 2005;Esteve et al, 2005;Ali et al, 2006). The findings of Ali et al (2006) are especially disturbing. They note that maternal ingestion of nimuselide, a coxib, may cause kidney failure in the unborn child.…”