Renal Transport Systems for Organic Anions and Cations in Cadmium-Exposed Rats

Kim, Kyoung Ryong; Kim, Ghi Chan; Choi, Jong Soo; Ahn, Do Whan; Park, Yang Saeng

doi:10.1006/taap.1998.8374

Cited by 6 publications

(3 citation statements)

References 17 publications

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“…exchanger, was inhibited with reduction in V max and no change in K m (Kim et al 1998). The P-glycoprotein or MDR1 was studied in a rat proximal tubule cell line.…”

Section: Organic Cations (Oc)mentioning

confidence: 92%

“…-alpha-ketoglutarate cotransport itself in BLMV was also significantly inhibited after the 3rd week of Cd 2? exposure (Kim et al 1998). …”

Section: Organic Anions (Oa)mentioning

confidence: 99%

“…In BBMVs of intoxicated rats (Suzuki and Cherian 1988;Lee et al 1990;Kim et al 1998) or control animals (Suzuki and Cherian 1988) the proton gradient-dependent transport of tetraethylammonium, TEA, a substrate for the OC/H ? exchanger, was inhibited with reduction in V max and no change in K m (Kim et al 1998).…”

Section: Organic Cations (Oc)mentioning

confidence: 99%

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Cadmium and transport of ions and substances across cell membranes and epithelia

2010

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Toxic metals such as cadmium (Cd(2+)) pose serious risks to human health. However, even though the importance of Cd(2+) as environmental health hazards is now widely appreciated, the specific mechanisms by which it produces its adverse effects have yet to be fully elucidated. Cd(2+) is known to enter cells, it binds and interacts with a multitude of molecules, it may indirectly induce oxidative stress and interfere with gene expression and repair of DNA. It also interacts with transport across cell membranes and epithelia and may therefore disturb the cell's homeostasis and function. Interaction with epithelial transport, especially in the kidney and the liver, may have serious consequences in general health. A lot of research still needs to be done to understand the exact way in which Cd(2+) interferes with these transport phenomena. It is not always clear whether Cd(2+) has primary or secondary effects on cell membrane transport. In the present review we try to summarize the work that has been done up to now and to critically discuss the relevance of the experimental work in vitro with respect to the in vivo situation.

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“…exchanger, was inhibited with reduction in V max and no change in K m (Kim et al 1998). The P-glycoprotein or MDR1 was studied in a rat proximal tubule cell line.…”

Section: Organic Cations (Oc)mentioning

confidence: 92%

“…-alpha-ketoglutarate cotransport itself in BLMV was also significantly inhibited after the 3rd week of Cd 2? exposure (Kim et al 1998). …”

Section: Organic Anions (Oa)mentioning

confidence: 99%

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Cadmium and transport of ions and substances across cell membranes and epithelia

2010

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Expression of basolateral organic anion and cation transporters in experimental cadmium nephrotoxicity in rat kidney

et al. 2015

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Cadmium (Cd)-intoxicated experimental animals exhibit impaired renal secretion of organic anions (OA) and cations (OC), indicating their transporters (Oats and Octs) in the proximal tubule (PT) basolateral membrane as possible targets of Cd. To correlate transport data from the literature with the expression of relevant transporters, we performed immunochemical and RT-PCR studies of renal Oats and Octs in the subchronic (treatment with CdCl2; 2 mg Cd/kg b.m./day, for 2 weeks) and acute (treatment with Cd-metallothionein (CdMT); 0.4 mg Cd/kg b.m., 6 or 12 h before killing) models of Cd nephrotoxicity. In the subchronic model, PT exhibited a minor loss of basolateral invaginations and overall unchanged expression of Na(+)/K(+)-ATPase and GAPDH proteins and mRNAs, while the expression of Oat and Oct proteins and their mRNAs was strongly downregulated. In the acute model, a time-related redistribution of basolateral transporters to the intracellular vesicular compartment was a major finding. However, 6 h following CdMT treatment, the total abundance of Oat and Oct proteins in the renal tissue remained unchanged, the expression of mRNAs decreased only for Oats, while a limited Oat1 and Na(+)/K(+)-ATPase immunoreactivity in the PT apical membrane indicated loss of cell polarity. As tested in rats treated with colchicine, the observed loss/redistribution of basolateral transporters in both models may be independent on microtubules. Therefore, the diminished renal secretion of OA and OC via PT in Cd nephrotoxicity may result from (a) limited loss of secretory surface (basolateral invaginations), (b) selective loss of Oats and Octs, and

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Presynaptic malfunction: The neurotoxic effects of cadmium and lead on the proton gradient of synaptic vesicles and glutamate transport

Borisova

Krisanova

Sivko

et al. 2011

Neurochemistry International

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Renal Transport Systems for Organic Anions and Cations in Cadmium-Exposed Rats

Cited by 6 publications

References 17 publications

Cadmium and transport of ions and substances across cell membranes and epithelia

Cadmium and transport of ions and substances across cell membranes and epithelia

Expression of basolateral organic anion and cation transporters in experimental cadmium nephrotoxicity in rat kidney

Presynaptic malfunction: The neurotoxic effects of cadmium and lead on the proton gradient of synaptic vesicles and glutamate transport

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