Renal sonography in the diagnosis of renal obstruction or hydronephrosis in patients with cervical cancer

Vanderpuye, Verna

doi:10.1002/jcu.10092

Cited by 12 publications

(10 citation statements)

References 9 publications

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“…Investigations such as intravenous pyelogram (IVP), magnetic Resonance imaging (MRI), cystoscopy and urine for culture and sensitivity were not performed due to limited funds. However, ultrasound has shown a high sensitivity for detecting hydronephrosis when compared to IVP [ 22 ]. The frequency of stage IIB, bladder metastasis and urinary tract infections may have been underestimated as MRI, cystoscopy and urine for culture and sensitivity were not performed.…”

Section: Discussionmentioning

confidence: 99%

Patient and disease characteristics associated with late tumour stage at presentation of cervical cancer in northwestern Tanzania

Mlange¹,

Matovelo²,

Rambau³

et al. 2016

BMC Women's Health

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BackgroundAbout two thirds of patients with cervical cancer in Tanzania present with advanced tumor stage, leading to significant morbidity and mortality. We designed a study to determine the factors associated with the late tumour stage at presentation among patients with cervical cancer in Mwanza.MethodsThis cross-sectional study recruited women at Bugando Medical Centre (BMC) with histologically confirmed cervical cancer from November 2013 to April 2014. Patients were recruited serially until the sample size was reached.ResultsA total of 202 women with histologically confirmed cervical cancer were recruited. The mean age of the patients was 50.5 ± 13.3 years. The majority of patients (n = 129, 63.9 %) were diagnosed with late stage disease (IIB-IVB). Patients also presented with severe anemia (n = 78, 38.6 %), urinary tract infections (n = 74, 36.6 %), hydronephrosis (n = 43, 21.2 %), elevated serum creatinine levels (n = 33, 16.3 %), vesicovaginal fistula (VVF), (n = 13, 6.4 %), lung metastasis (n = 5, 2.4 %), metastasis to the urinary bladder (n = 4, 1.9 %), rectovaginal fistula (RVF) (n = 3, 1.4 %), liver metastasis (n = 2, 0.9 %) and hydroureter (n = 2, 0.9 %). In multivariate logistic regression, factors associated with late stage at presentation were attending to alternative health practitioners and lack of personal initiative to seek care to formal health facilities (OR 2.3; 95 % CI 1.2–4.2, p = 0.011 and OR 2.0; 95 % CI 1.0–3.8, p = 0.028) respectively.ConclusionCommunities should be sensitized to women’s empowerment, provide community education on early symptoms of cervical cancer, and the importance of early hospital attendance.

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Section: Discussionmentioning

confidence: 99%

Patient and disease characteristics associated with late tumour stage at presentation of cervical cancer in northwestern Tanzania

Mlange¹,

Matovelo²,

Rambau³

et al. 2016

BMC Women's Health

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“…However, ultrasound was used to measure tumor volume and to look for the presence of hydronephrosis and hydroureter. It has been shown that ultrasound has a very high sensitivity for detecting hydronephrosis and tumor volume [23,24]. In Mulago Hospital, because of logistical problems, cystoscopy is usually not performed during examination under anesthesia, so the prevalence of bladder involvement might have been underestimated.…”

Section: Discussionmentioning

confidence: 99%

Urologic complications among women with advanced cervical cancer at a tertiary referral hospital in Uganda

Atuhairwe¹,

Busingye²,

Sekikubo³

et al. 2011

International Journal of Gynecology & Obstetrics

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“…Using the sample size formula for testing sensitivity of a single diagnostic test, 10 a minimum target size of 126 participants was computed. This sample size would be able to detect a difference of 10% from the presumed sensitivity of 76.5% for renal US, 9 with α of 0.05 and β of 0.20. All eligible patients referred to the Department of Radiology of PGH were enrolled until the target sample size was reached.…”

Section: Methodsmentioning

confidence: 99%

“…It was reported to have a sensitivity of 76.5%, specificity of 100%, positive predictive value of 100%, and negative predictive value of 85% when compared with IVP or CT as reference standards. 9 However, this previous study was conducted with small sample size, and the reference standard used was not uniform for all patients. This study thus aimed to evaluate the performance of renal ultrasound in diagnosing ureteral obstruction or hydronephrosis among patients with grossly invasive cervical cancer, with nonenhanced CT as the reference standard, using more robust sample size and study design.…”

Section: Introductionmentioning

confidence: 97%

Diagnosis of Hydronephrosis or Ureteral Obstruction using Renal Sonography among Patients with Cervical Cancer

2021

Acta Med Philipp

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Background. Cervical cancer is the second most common malignancy among Filipino women. The recent 2018 FIGO guidelines recommend imaging in cases of grossly invasive disease to determine the presence of hydronephrosis, which would immediately classify the disease as at least stage IIIB. CT and MRI are state-of-the-art modalities that can provide such information; however, these are costly and may not be accessible in areas with limited resources. Sonography is a safe and inexpensive alternative in this regard.Objective. This study aimed to evaluate the diagnostic performance of renal sonography in identifying the presence of ureteral obstruction or hydronephrosis among patients with grossly invasive cervical cancer, with non-enhanced CT as the reference standard. Methods.A blinded, prospective study was conducted among patients diagnosed with grossly invasive cervical cancer from the Philippine General Hospital. Participants underwent same-day evaluation with both renal sonography and non-enhanced CT. The presence of either ureteral obstruction or hydronephrosis secondary to cervical cancer was independently determined. The sensitivity, specificity, positive predictive value, and negative predictive value of renal sonography were calculated, with non-enhanced CT as the reference standard. Results.A total of 127 participants were enrolled. The mean age was 46 years, with a range of 24 to 65 years. The majority had stage IIB (41.7%) and stage IIIB (52.0%) disease. On non-enhanced CT, 46 (36.2%) showed evidence of ureteral obstruction or hydronephrosis, while 81 (63.8%) had negative results. On renal sonography, 46 (36.2%) had positive results, and 81 (63.8%) had negative findings. The sensitivity, specificity, and positive and negative predictive values of sonography were 91.3%, 95.1%, 91.3%, and 95.1%, respectively. Among patients with stage IIIB disease, sonography was shown to have higher sensitivity and specificity of 92.1% and 96.4%, respectively. Meanwhile, among patients with stage IB to IIB disease, its sensitivity and specificity were 87.5% and 94.3%, respectively. Conclusion.Renal sonography has high sensitivity and specificity in the diagnosis of ureteral obstruction or hydronephrosis in patients with grossly invasive cervical cancer. Its sensitivity is higher when used in patients with stage IIIB disease, compared with those having lower-stage tumors.

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Renal sonography in the diagnosis of renal obstruction or hydronephrosis in patients with cervical cancer

Abstract: Renal sonography may be used as an effective and relatively low-cost means of diagnosing ureteral obstruction in patients with cervical cancer without clinically evident pelvic sidewall thickening.

Cited by 12 publications

References 9 publications

Patient and disease characteristics associated with late tumour stage at presentation of cervical cancer in northwestern Tanzania

Patient and disease characteristics associated with late tumour stage at presentation of cervical cancer in northwestern Tanzania

Urologic complications among women with advanced cervical cancer at a tertiary referral hospital in Uganda

Diagnosis of Hydronephrosis or Ureteral Obstruction using Renal Sonography among Patients with Cervical Cancer

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