Urologic complications among women with advanced cervical cancer at a tertiary referral hospital in Uganda

Atuhairwe, Susan; Busingye, Robert B.; Sekikubo, Musa; Nakimuli, Annettee; Mutyaba, Twaha

doi:10.1016/j.ijgo.2011.07.021

Cited by 16 publications

(24 citation statements)

References 16 publications

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“…Anemia and hydronephrosis were the most common complications seen in this study. These findings were similar to studies done in Uganda and Minnesota [ 6 , 17 ]. In this study; 65.1 % of the sample had unilateral hydronephrosis, and elevated serum creatinine was found in 16.3 % of all patients.…”

Section: Discussionsupporting

confidence: 92%

“…In this study VVF was found in 6.4 % of all patients with cervical cancer which was similar to studies done in Minnesota (7 %) and Uganda (7.4 %) respectively [ 6 , 17 ].…”

Section: Discussionsupporting

confidence: 90%

“…These findings are similar to a study done in Sub-Saharan Africa where most of their patients 56 % had unilateral hydronephrosis and 15.1 % of patients had elevated serum creatinine [ 18 ]. Our study found that elevated serum creatinine (16.3 %) was less than what was previously reported in Uganda (71.4 %) [ 6 ]. The low occurrence of elevated serum creatinine in our study is due to the inclusion of all patients with cervical cancer while for a study in Uganda only patients with hydronephrosis were included.…”

Section: Discussioncontrasting

confidence: 66%

“…Patients who present with advanced stage disease are more likely to develop complications such as anemia, ureteric obstruction with hydroureter and hydronephrosis, renal failure and urinary tract infection [ 5 , 6 ]. Cervical cancer may present with abnormal vaginal discharge, contact vaginal bleeding, loin pain, changes in urine output, hematuria and increased serum creatinine, vesicovaginal fistula (VVF) and rectovaginal fistula (RVF) [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Patient and disease characteristics associated with late tumour stage at presentation of cervical cancer in northwestern Tanzania

Mlange¹,

Matovelo²,

Rambau³

et al. 2016

BMC Women's Health

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BackgroundAbout two thirds of patients with cervical cancer in Tanzania present with advanced tumor stage, leading to significant morbidity and mortality. We designed a study to determine the factors associated with the late tumour stage at presentation among patients with cervical cancer in Mwanza.MethodsThis cross-sectional study recruited women at Bugando Medical Centre (BMC) with histologically confirmed cervical cancer from November 2013 to April 2014. Patients were recruited serially until the sample size was reached.ResultsA total of 202 women with histologically confirmed cervical cancer were recruited. The mean age of the patients was 50.5 ± 13.3 years. The majority of patients (n = 129, 63.9 %) were diagnosed with late stage disease (IIB-IVB). Patients also presented with severe anemia (n = 78, 38.6 %), urinary tract infections (n = 74, 36.6 %), hydronephrosis (n = 43, 21.2 %), elevated serum creatinine levels (n = 33, 16.3 %), vesicovaginal fistula (VVF), (n = 13, 6.4 %), lung metastasis (n = 5, 2.4 %), metastasis to the urinary bladder (n = 4, 1.9 %), rectovaginal fistula (RVF) (n = 3, 1.4 %), liver metastasis (n = 2, 0.9 %) and hydroureter (n = 2, 0.9 %). In multivariate logistic regression, factors associated with late stage at presentation were attending to alternative health practitioners and lack of personal initiative to seek care to formal health facilities (OR 2.3; 95 % CI 1.2–4.2, p = 0.011 and OR 2.0; 95 % CI 1.0–3.8, p = 0.028) respectively.ConclusionCommunities should be sensitized to women’s empowerment, provide community education on early symptoms of cervical cancer, and the importance of early hospital attendance.

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Section: Discussionsupporting

confidence: 92%

“…In this study VVF was found in 6.4 % of all patients with cervical cancer which was similar to studies done in Minnesota (7 %) and Uganda (7.4 %) respectively [ 6 , 17 ].…”

Section: Discussionsupporting

confidence: 90%

Section: Discussioncontrasting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Patient and disease characteristics associated with late tumour stage at presentation of cervical cancer in northwestern Tanzania

Mlange¹,

Matovelo²,

Rambau³

et al. 2016

BMC Women's Health

View full text Add to dashboard Cite

show abstract

“…Other benign causes of VVF are gynecological surgeries like hysterectomy, pelvic irradiation, pelvic inflammatory diseases, uterine rupture, and so forth [6, 7]. Malignant causes of VVF are carcinoma of cervix, vagina, bladder, and endometrium [8]. A fistula that occurs in association with a malignancy of the female reproductive tract may be caused by a primary or recurrent tumor or may be a complication of surgery or radiation therapy [9].…”

Section: Discussionmentioning

confidence: 99%

Adenosquamous Carcinoma of Vesicovaginal Fistula: A Rare Entity

Tabali

Ramkumar

2014

Case Reports in Obstetrics and Gynecology

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A 56-year-old lady presented with a vesicovaginal fistula (VVF) along with past history of abdominal hysterectomy. Biopsy of the fistulous tract showed squamous cell carcinoma (SCC). Patient underwent radical cystourethrectomy, total vaginectomy, and bilateral pelvic lymph node dissection along with ileal conduit. The final histopathology report of the resected specimen showed adenosquamous carcinoma in VVF. As this is a rare entity, we are reporting this case.

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Hydronephrosis in patients with cervical cancer: an assessment of morbidity and survival

Patel

Foster

Kumar

et al. 2014

Support Care Cancer

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Purpose Hydronephrosis is a frequently observed but understudied complication in patients with cervical cancer. To better characterize hydronephrosis in cervical cancer patients, the current study sought (1) to describe hydronephrosis-associated morbidity and (2) to analyze the prognostic effect of hydronephrosis in patients with a broad range of cancer stages over time. Methods The Mayo Clinic Tumor Registry was interrogated for all invasive cervical cancer patients seen at the Mayo Clinic from 2008 through 2013 in Rochester, Minnesota; these patients’ medical records were then reviewed in detail. Results Two hundred seventy-nine cervical cancer patients with a median age of 49 years and a range of cancer stages were included. Sixty-five patients (23 %) were diagnosed with hydronephrosis at some point during their disease course. In univariate analyses, hydronephrosis was associated with advanced cancer stage (p<0.0001), squamous histology (p=0.0079), and nonsurgical cancer treatment (p=0.0039). In multivariate analyses, stage and tumor histology were associated with hydronephrosis. All but one patient underwent stent placement or urinary diversion; hydronephrosis-related morbidity included pain, urinary tract infections, nausea and vomiting, renal failure, and urinary tract bleeding. In landmark univariate survival analyses, hydronephrosis was associated with worse survival at all time points. In landmark multivariate analyses (adjusted for patient age, stage, cancer treatment, and tumor histology), hydronephrosis was associated with a trend toward worse survival over time (hazard ratios ranged from 1.47 to 4.69). Conclusion Hydronephrosis in cervical cancer patients is associated with notable morbidity. It is also associated with trends toward worse survival—even if it occurs after the original cancer diagnosis.

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Urologic complications among women with advanced cervical cancer at a tertiary referral hospital in Uganda

Abstract: There is a high prevalence of urologic complications among women with advanced cervical cancer; these complications are significantly associated with the stage of cervical cancer.

Cited by 16 publications

References 16 publications

Patient and disease characteristics associated with late tumour stage at presentation of cervical cancer in northwestern Tanzania

Patient and disease characteristics associated with late tumour stage at presentation of cervical cancer in northwestern Tanzania

Adenosquamous Carcinoma of Vesicovaginal Fistula: A Rare Entity

Hydronephrosis in patients with cervical cancer: an assessment of morbidity and survival

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