Renal Response in Low-Birth-Weight Neonates

Stonestreet, Barbara S.

doi:10.1001/archpedi.1983.02140290007002

Cited by 40 publications

(6 citation statements)

References 20 publications

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“…But sodium bromide, the indicator he used to measure extracellular volume, is not confined to the extracellular space, but enters cells in about 10% of the dose given (1 3). Stonestreet (6) also found that the weight loss between day 2 and day 10 of life in preterm infants could be explained as water loss from the extracellular volume (Vd inulin). But she did no measurement early after birth, thus missing the immediate postnatal changes.…”

Section: Discussionmentioning

confidence: 97%

Postnatal Weight Loss in Preterm Neonates <1500 g is Due to Isotonic Dehydration of the Extracellular Volume

Bauer

Versmold

1989

Acta Paediatrica

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FRG). Postnatal weight loss in preterm neonates < 1 500 g is due to isotonic dehydration of the extracellular volume. Acta Paediatr Scand Suppl360: 37, 1989. Weight, extracellular volume (ECV, distribution volume of sucrose) and renal function were studied in 13 preterm infants at birth (age 6 h (2-12); median, range) and again when postnatal weight loss exceeded 5 % of birth weight (age 84 (64-97) h). Gestational age was 28 (26-32) weeks, and birthweight was 1170 g (810-1 455). The infants were nursed in incubators and mechanically ventilated. Fluid therapy allowed a weight loss of up to 10% of birthweight. Body weight decreased significantly from 1 101 2 202 g at birth to 1016 2 198 g a t day 3 and ECV from 499? 155 ml to 4132118 ml. Mean weight loss of 8 5 2 5 0 g was the same as mean ECV loss of 86 +-48 ml, suggesting that postnatal weight loss is water loss from the ECV. Weight loss was preceeded by a marked increase in diuresis, exceeding fluid intake on day 2. Creatinine clearance did not change. The increased urine output led to a significant increase of sodium excretion without inducing hyponatremia but resulted in an isotonic reduction of ECV.

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Section: Discussionmentioning

confidence: 97%

Postnatal Weight Loss in Preterm Neonates <1500 g is Due to Isotonic Dehydration of the Extracellular Volume

Bauer

Versmold

1989

Acta Paediatrica

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“…- Phototherapy (PT): Although studies conducted in the 1970s suggested that PT caused vasodilatation by passing through the thin skin of preterms, current studies in which the diagnosis of PDA is made using echocardiography do not support the hypothesis that PT increases the frequency of PDA or elevates serum PGE 2 levels (11, 12). - Postnatal fluid management: Studies that associated high amounts of fluid given in the first days of life with PDA were conducted in the 1970s-1980s and made the diagnosis of PDA with ‘murmur.’ It has been proposed that excessive fluid in VLBW babies will increase PGE 2 levels (13). Currently, it is recommended that fluid management should be conducted with close monitoring of vital signs, urine output, and biochemical results and 170 mL/kg should not be exceeded.- Sepsis: Sepsis delays closure, decreases the response given to pharmacologic agents, and may lead to reopening of PDA.- Intrauterine growth retardation: In the study conducted by Rakza et al (14), the frequency of hemodynamically significant PDA (HSPDA) at the 48 th hour was found as 40% in appropriate-for-gestational-age (AGA) babies and 65% in small-for-gestational-age (SGA) babies.- Genetic factors: More than 4000 genes are expressed in the ductal tissue.…”

Section: Introductionmentioning

confidence: 99%

“…- Postnatal fluid management: Studies that associated high amounts of fluid given in the first days of life with PDA were conducted in the 1970s-1980s and made the diagnosis of PDA with ‘murmur.’ It has been proposed that excessive fluid in VLBW babies will increase PGE 2 levels (13). Currently, it is recommended that fluid management should be conducted with close monitoring of vital signs, urine output, and biochemical results and 170 mL/kg should not be exceeded.…”

Section: Introductionmentioning

confidence: 99%

Turkish Neonatal Society guideline on the management of patent ductus arteriosus in preterm infants

2019

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Ductus arteriosus is a physiologic phenomenon in utero and it closes spontaneously in term babies. The closure is problematic in preterm infants due to the intrinsic properties of the preterm ductus arteriosus tissue. Although patent ductus arteriosus has been reported to be associated with many adverse outcomes in this population, treatment has not led to a decrease in outcomes such as bronchopulmonary dysplasia. Treatment modalities also have their own risks and restrictions. The aim of the “Turkish Neonatal Society guidelines for the management of patent ductus arteriosus in preterm babies” is to standardize the diagnosis and treatment of patent ductus arteriosus in preterm infants by combining the current scientific data and the resources of our country.

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“…This may be due to immaturity [1], inappropriate urinary [2] or gastrointestinal salt toss [3], or iatrogenic causes, such as inappropriately limited salt intake or the chronic administration of potent diuretics [4]. In any case, if they are children, they often demonstrate diminished growth rates for both weight and length.…”

Section: Introductionmentioning

confidence: 99%

The effect of sodium repletion on growth and protein turnover in sodium-depleted rats

Wassner

1991

Pediatr Nephrol

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This study examines the consequences of sodium chloride supplementation to young rats previously made salt deficient by feeding them a sodium-deficient, chloride-replete diet. Salt-deficient rats received the test diet and distilled water for 10 days. As in our previous studies, rats cared for in this manner grew more slowly than rats fed the identical diet but allowed to drink 37 mM sodium chloride. On day 11, half of the salt-depleted animals received 37 mM sodium chloride in their drinking water. Sodium-deficient and supplemented rats were studied 1,2,5-6 and 11-12 days later. Urinary sodium rapidly rose from undetectable of 46 mEq/l urine within 1 day of supplementation and there was no further increase the next day, suggesting that extracellular fluid volumes were rapidly repleted. Food intake increased in the supplemented rats compared with the deficient animals but the difference in food intake equalled only 2.25 g/day for the first 2 days of supplementation. Over the last 12 days of the study, the slopes of both weight and length gains were equal in both the supplemented and the control group and significantly higher than those in the deficient rats. Over the course of the study, full catchup was not obtained in either length or weight. In addition to total weight and length gains, liver and kidney weights increased proportionately and by 5-6 days of supplementation were equivalent to the weights seen in the control group.(ABSTRACT TRUNCATED AT 250 WORDS)

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Renal Response in Low-Birth-Weight Neonates

Cited by 40 publications

References 20 publications

Postnatal Weight Loss in Preterm Neonates <1500 g is Due to Isotonic Dehydration of the Extracellular Volume

Postnatal Weight Loss in Preterm Neonates <1500 g is Due to Isotonic Dehydration of the Extracellular Volume

Turkish Neonatal Society guideline on the management of patent ductus arteriosus in preterm infants

The effect of sodium repletion on growth and protein turnover in sodium-depleted rats

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