Turkish Neonatal Society guideline on the management of patent ductus arteriosus in preterm infants

Köksal, Nilgün; Aygün, Canan; Uraş, Nurdan

doi:10.5152/turkpediatriars.2018.01808

Cited by 26 publications

(41 citation statements)

References 49 publications

(95 reference statements)

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“…RDS was diagnosed based on clinical, laboratory, and radiological findings. In this study, hemodynamically PDA was considered, and the diagnosis of PDA was made based on clinical and echocardiographic findings (ratio of left atrium diameter to aortic diameter >1.4) (19). For the diagnosis of NEC, Bell's criteria were used, and any stage of NEC was recorded (20).…”

Section: Methodsmentioning

confidence: 99%

Neonatal Thrombocytopenia and the Role of the Platelet Mass Index in Platelet Transfusion in the Neonatal Intensive Care Unit

et al. 2020

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Section: Methodsmentioning

confidence: 99%

Neonatal Thrombocytopenia and the Role of the Platelet Mass Index in Platelet Transfusion in the Neonatal Intensive Care Unit

et al. 2020

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“…In the presence of hsPDA, there are different opinions about giving early medical closure treatment. The tendency to give conservative treatment has increased due to some of the reasons listed below: a) <1000g infants have 40% spontaneous closure, b) early closure treatment is related to gastrointestinal bleeding, NEC, and oliguria, c) early treatment does not cause a decrease in BPD, NEC, and neurodevelopmental morbidity (9,22). On the other hand, Klukow et al (23) in 2014, detected large PDA in 92 (56.2%) of 164 babies born under 29 GW, 44 of these babies gave indomethacin and 48 placebos.…”

Section: Discussionmentioning

confidence: 99%

“…Some guidelines are suggesting early echocardiographic imaging and early closure treatment in infants with ELBW, as well as some studies recommending follow-up symptoms without echocardiographic imaging in the first week (9,10). In this study, we aimed to investigate the necessity of performing ECHO in the first 72 hours for the diagnosis of PDA in infants with ELBW.…”

Section: Introductionmentioning

confidence: 99%

Should Echocardiographic Evaluation Be Performed Routinely in the First 72 Hours in Extremely Low Birth Weight Babies?

Çolak¹,

Özdemir²,

Ergon³

et al. 2021

Gynecol Obstet Reprod Med

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Objective: Hemodynamically significant patent ductus arteriosus(hsPDA) is resulting in severe mortality and morbidity in infants with extremely low birth weight(ELBW). In our study, we aimed to evaluate the necessity of performing routine echocardiography(ECHO) in the first 72hours in ELBW infants.Study Design:This study was planned retrospectively and observationally.Between June2016 and December2018,36 patients diagnosed with hemodynamically significant PDA(hsPDA) who were hospitalized in the neonatal intensive care unit(NICU),with ≤28Gw or ≤1000g were included in this study.These babies were routinely performed ECHO for PDA between 24-72hours,although they were asymptomatic in the period from June2016 to December2017(n:23).Between January2018 and December2018, patients without PDA symptoms were expected to complete 72hours for routine PDA screening (n:13).The patients were divided into 2 groups as early ECHO group(EEG)(n=23) and late ECHO group (LEG)(n=13).In the presence of at least one of the clinical signs of systemic hypoperfusion and/or pulmonary hyperperfusion, symptomatic PDA was accepted and closure treatment was applied with ibuprofen(n: 23) or paracetamol(n: 5).While the two groups were compared in terms of demographic features,ECHO findings,and the state of taking closure therapy,patients receiving closure therapy were compared in terms of mortality and premature morbidity.Results:The average birth weight of 36 patients was 855.9(± 241.5)g, and the average week of birth was 26.4(± 2.1)Gw.It was observed that the two groups were similar in terms of demographic characteristics.Although the findings of ECHO and treatment rates were similar between the two groups,it was observed that the EEG had earlier closure treatment(p = 0.03). In patients receiving closure treatment, performing early(n:17)and late(n:11) echocardiography showed no statistical difference in the long-term results.Conclusion:Performing early ECHO without symptoms in infants with ELBW may provoke the clinician to give PDA closure treatment earlier. In infants with ELBW,unnecessary closure treatment can be prevented by closely monitoring the symptoms of PDA and performing ECHO when necessary.

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“…Either ibuprofen or paracetamol was given according to clinical findings of the infants and laboratory data. Ibuprofen was used for three consecutive days at a dose of 10 mg/kg/day on the 1st day, 5 mg/kg/day on the 2nd day, and 5 mg/kg/day on the 3rd day (21). The paracetamol treatment was administered The highest score will be given according to pH or BD.…”

Section: Methodsmentioning

confidence: 99%

SIMPLE: A Novel Scoring System for Predicting Hemodynamically Significant Patent Ductus Arteriosus Without Echocardiographic Evaluation in Extremely Low Birth Weight Infants

et al. 2021

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Aim: To develop a novel clinical scoring system for predicting hemodynamically significant patent ductus arteriosus (hsPDA) in extremely low birth weight (ELBW) infants.Methods: A prospective observational study was conducted among ELBW infants born in the study center during a 6-month period. Fourteen items were selected on a literature review basis and weighed by severity on an arbitrary 1–4 scale, the sum of which represented the Scoring preterm Infants for PDA cLinically without Echocardiographic evaluation (SIMPLE) score. The SIMPLE scores were compared at several time points during the first 3 days of life between two groups of patients: those with an hsPDA at echocardiography and those without.Results: A total of 48 ELBW infants were enrolled, of which 30 infants developed hsPDA. The SIMPLE scores of the infants with hsPDA were significantly greater than those of the infants who did not develop hsPDA. Cut-off SIMPLE scores that were significantly associated with detection of symptomatic hsPDA at each evaluation time point were identified.Conclusions: SIMPLE is the first scoring system that depends on the risk factors and clinical findings of ELBW infants for early prediction of hsPDA. It is simple, objective and easy to perform, and it does not require any additional tests and/or echocardiographic evaluation. We suggest that SIMPLE can be used as a screening tool for determining the need for echocardiographic evaluation in ELBW infants in order to minimize the number of unnecessary pediatric cardiology consultations.

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Turkish Neonatal Society guideline on the management of patent ductus arteriosus in preterm infants

Cited by 26 publications

References 49 publications

Neonatal Thrombocytopenia and the Role of the Platelet Mass Index in Platelet Transfusion in the Neonatal Intensive Care Unit

Neonatal Thrombocytopenia and the Role of the Platelet Mass Index in Platelet Transfusion in the Neonatal Intensive Care Unit

Should Echocardiographic Evaluation Be Performed Routinely in the First 72 Hours in Extremely Low Birth Weight Babies?

SIMPLE: A Novel Scoring System for Predicting Hemodynamically Significant Patent Ductus Arteriosus Without Echocardiographic Evaluation in Extremely Low Birth Weight Infants

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