Renal replacement therapy in critically ill patients with acute kidney injury: 2020 nephrologist’s perspective

Valdenebro, María; Martín-Rodríguez, Leyre; Tarragón, Blanca; Sánchez-Briales, Paula; Pórtoles, José

doi:10.1016/j.nefroe.2021.05.003

Cited by 7 publications

(3 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At present, one of the effective clinical treatments for AKI is blood purification, among which intermittent hemodialysis (IHD) and continuous renal replacement therapy (CRRT) are more commonly used [ 7 ]. IHD adopts the principle of diffuse convection to remove harmful substances such as inflammatory mediators and endogenous and exogenous toxins in the blood of patients through dialysis equipment, which has a certain effect on improving the patient's condition [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Continuous Renal Replacement Therapy and Intermittent Hemodialysis in Patients with Renal Failure in Intensive Care Unit: A Systemic Review and Meta‐analysis

Liu

et al. 2023

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objective. This study aimed to compare the clinical efficacy of continuous renal replacement therapy (CRRT) and intermittent hemodialysis (IHD) in patients with renal failure in intensive care unit (ICU). Methods. Relevant studies were searched in the databases including EMBASE, Cochrane Library, and MEDLINE (PubMed) from inception to January 04, 2021. The inclusion of available studies and the collection of data were independently conducted by two authors after reviewing the full text. Pooled analyses of relative risk (RR) and weighted mean difference (WMD) were performed to compare the outcomes of renal recovery, short-term mortality, length of ICU stays, and length of in-hospital stays between the two different treatment groups. Publication bias was assessed by the funnel plot. Results. A total of 11 RCT studies including 1740 patients with renal failure were eligible for final analysis. Among them, 894 patients (51.4%) underwent CRRT and 846 patients (48.6%) received IHD. Pooled analysis did not find significant differences in renal recovery and short-term mortality between the two groups. Interestingly, patients underwent CRRT showed significantly shorter length of ICU stay and in-hospital stay than those who underwent IHD (ICU stay: RR: −0.61, 95%CI: −1.10—−0.11, P < 0.05 ; I2 = 93.6%; in-hospital stay: RR: −0.56, 95%CI: −1.41–0.28, P < 0.05 ; I2 = 97.7%). No significant publication biases were observed on the funnel plots. Conclusion. Compared with IHD, CRRT had similar effects on renal recovery and short-term mortality in patients with renal failure in ICU. As a promising technique in clinical practice, CRRT could significantly reduce the length of ICU stay and in-hospital stay of patients, which was of great significance for the reduction of medical costs and the long-term benefits of patients, thereby reducing the burden on society and individuals.

show abstract

Section: Introductionmentioning

confidence: 99%

Efficacy of Continuous Renal Replacement Therapy and Intermittent Hemodialysis in Patients with Renal Failure in Intensive Care Unit: A Systemic Review and Meta‐analysis

Liu

et al. 2023

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Educating patients and implementing a PD-first strategy in all dialysis patients can improve patient experience and mortality rates while saving money on the rising cost of ESRD therapy. 8,9 Peritoneal dialysis has infectious and non-infectious problems. Peritonitis, catheter exit, and tube tunnel infections are related with peritoneal dialysis.…”

Section: Introductionmentioning

confidence: 99%

Peritoneal Dialysis-Associated Peritonitis : a Systematic Review

Amelia¹

2023

JARMHS

View full text Add to dashboard Cite

Background: Peritoneal dialysis is infectious and non-infectious. Peritoneal dialysis causes catheter exit, tube tunnel, and peritonitis. Noninfectious consequences of peritoneal dialysis include catheter malfunction, external leakage, abdominal wall anomalies, scrotal edoema, pleural-peritoneal fistulas, failed ultrafiltration, and encapsulated sclerosis. PD complications include peritonitis. The International Society for Peritoneal Dialysis (ISPD) offers specific recommendations on PD-associated peritonitis prevention and treatment, however clinical practise differs greatly amongst dialysis units. Aim: This article examines the link between peritoneal dialysis and peritonitis and presents its findings. Methods: By evaluating the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020 standards, this study demonstrated that it met all of the requirements. This enabled the researchers to ensure that the study was as up to date as feasible. Publications published between 2000 and 2023 were included in the search strategy, which included a variety of electronic reference databases (including Pubmed and SagePub). We did not consider review papers, duplicate publications, or half completed articles. Result: In the PubMed database, the results of our search brought up 133 articles, whereas the results of our search on SagePub brought up 69 articles. The results of the search conducted for the last year of 2000 yielded a total of 20 articles for PubMed and 8 articles for SagePub. In the end, we compiled a total of 21 papers, six of which came from PubMed and three of which came from SagePub. We included nine research that met the criteria. Conclusion: Gram-positive bacteria are the most common cause of Parkinson's disease-associated peritonitis. Despite the high frequency of PD-associated peritonitis, it has a high cure rate.

show abstract

“…Acute kidney injury (AKI) is characterized with a rapid renal dysfunction, post-disease renal fibrosis and renal failure (1). Ischemia/reperfusion injury (IRI) is one of the major causes of AKI (2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Clec7a expression in inflammatory macrophages orchestrates progression of acute kidney injury

Wang

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

Acute kidney injury (AKI) is associated with high risk of mortality, post-disease renal fibrosis, kidney dysfunction and renal failure. Renal macrophages play a key role in the pathogenesis (M1 subpopulation), healing and remodeling (M2 subpopulation) in AKI and, thus, have been a promising target for clinical treatment of AKI. Here, in a mouse renal ischemia/reperfusion injury (IRI) model for AKI, we showed that renal macrophages could be further classified into Clec7a+ M1 macrophages, Clec7a- M1 macrophages, Clec7a+ M2 macrophages and Clec7a- M2 macrophages, representing distinct macrophage populations with different functionality. Interestingly, Clec7a+ M1 macrophages exhibited potent pro-inflammatory and phagocytic effects compared to Clec7a- M1 macrophages, while Clec7a- M2 macrophages exhibited better proliferating and migrating potential, which is critical for their role in tissue repairing after injury. These data from mice were further strengthened by bioinformatics analyses using published database. In vivo, combined expression of Clec7a in M1 macrophages and depletion of Clec7a in M2 macrophages significantly improved the renal function after IRI-AKI. Together, our data suggest that Clec7a is crucial for the fine regulation of macrophage phenotype during AKI and could be a novel target for boosting clinical therapy.

show abstract

Renal replacement therapy in critically ill patients with acute kidney injury: 2020 nephrologist’s perspective

Cited by 7 publications

References 70 publications

Efficacy of Continuous Renal Replacement Therapy and Intermittent Hemodialysis in Patients with Renal Failure in Intensive Care Unit: A Systemic Review and Meta‐analysis

Efficacy of Continuous Renal Replacement Therapy and Intermittent Hemodialysis in Patients with Renal Failure in Intensive Care Unit: A Systemic Review and Meta‐analysis

Peritoneal Dialysis-Associated Peritonitis : a Systematic Review

Clec7a expression in inflammatory macrophages orchestrates progression of acute kidney injury

Contact Info

Product

Resources

About