Efficacy of Continuous Renal Replacement Therapy and Intermittent Hemodialysis in Patients with Renal Failure in Intensive Care Unit: A Systemic Review and Meta‐analysis

Ma, Haiying; Liu, Hengjian; Liu, Yi; Wang, Yi; He, Jiang; Yang, Qiaoyun

doi:10.1155/2023/8688974

Cited by 2 publications

(1 citation statement)

References 35 publications

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“… 25 While continuous renal replacement therapy (CRRT) is considered a promising clinical technology that can potentially reduce ICU and hospital stays, decrease medical costs, provide long-term benefits to patients, and alleviate social and personal burdens, it is important to note that further research is required to fully assess its effectiveness and safety. 26 Whether renal replacement therapy has an effect on mortality in critically ill patients remains a topic of debate. 27 The effectiveness of relood purification therapy signifies a critical stage in the patient’s condition.…”

Section: Discussionmentioning

confidence: 99%

LASSO-Based Identification of Risk Factors and Development of a Prediction Model for Sepsis Patients

Hong,

Xiong,

Xia

et al. 2024

TCRM

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Objective The objective of this study was to utilize LASSO regression (Least Absolute Shrinkage and Selection Operator Regression) to identify key variables in septic patients and develop a predictive model for intensive care unit (ICU) mortality. Methods We conducted a cohort consisting of septic patients admitted to the ICU between December 2016 and July 2019. The disease severity and laboratory index were analyzed using LASSO regression. The selected variables were then used to develop a model for predicting ICU mortality. AUCs of ROCs were applied to assess the prediction model, and the accuracy, sensitivity and specificity were calculated. Calibration were also used to assess the actual and predicted values of the predictive model. Results A total of 1733 septic patients were included, among of whom 382 (22%) died during ICU stay. Ten variables, namely mechanical ventilation (MV) requirement, hemofiltration (HF) requirement, norepinephrine (NE) requirement, septicemia, multiple drug-resistance infection (MDR), thrombocytopenia, hematocrit, red-cell deviation width coefficient of variation (RDW-CV), C-reactive protein (CRP), and antithrombin (AT) III, showed the strongest association with sepsis-related mortality according to LASSO regression. When these variables were combined into a predictive model, the area under the curve (AUC) was found to be 0.801. The AUC of the validation group was 0.791. The specificity of the model was as high as 0.953. Within the probability range of 0.25 to 0.90, the predictive performance of the model surpassed that of individual predictors within the cohort. Conclusion Our findings suggest that a predictive model incorporating the variables of MV requirement, HF requirement, NE requirement, septicemia, MDR, thrombocytopenia, HCT, RDW-CV, CRP, and AT III exhibiting an 80% likelihood of predicting ICU mortality in sepsis and demonstrates high accuracy.

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Section: Discussionmentioning

confidence: 99%

LASSO-Based Identification of Risk Factors and Development of a Prediction Model for Sepsis Patients

Hong,

Xiong,

Xia

et al. 2024

TCRM

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Successful Application of a Hemoperfusion Machine in Separated System CRRT: Evaluating Effectiveness and Safety in Critically Ill Patients With AKI in Resource‐Limited Settings

Phongphithakchai,

Sirisuksan,

Konwai

et al. 2024

Seminars in Dialysis

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BackgroundIt is imperative to note that integrated system continuous renal replacement therapy (CRRT) necessitates a sophisticated and costly apparatus, potentially limiting its availability within resource‐limited settings. The introduction of a separated system for continuous veno‐venous hemofiltration (CVVH), characterized by uncomplicated setup procedures with a hemoperfusion machine, holds promise as a feasible alternative to CRRT for critically ill patients with acute kidney injury (AKI).MethodsWe aimed to retrospectively analyze the effectiveness and safety of separated CRRT applied from a hemoperfusion machine in critically ill patients with AKI during the January 2015 to December 2021 period. We also examine the in‐hospital mortality rate and multivariate logistic regression analysis to uncover the factors that affect mortality.ResultsWe included a total of 129 critically ill patients who received separated system CRRT. The SOFA score at CRRT initiation was 12.6 ± 3.8. The fluid accumulation at the day of CRRT initiation was 3900 mL (622–8172 mL) All patients received pre‐ and postdilution CVVH. The mean prescribed CRRT dose was 22.4 ± 3.1 mL/kg/h. We found no serious complications including circuit explosion and air embolism. The in‐hospital mortality rate was 68.9%. High SOFA score and positive fluid accumulation at CRRT initiation serve as predictors of survival.ConclusionsSeparated system CRRT using a hemoperfusion machine provides a simplified system to operate and is proven to be effective and safe in real‐life practice, especially in resource‐limited areas.

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Efficacy of Continuous Renal Replacement Therapy and Intermittent Hemodialysis in Patients with Renal Failure in Intensive Care Unit: A Systemic Review and Meta‐analysis

Cited by 2 publications

References 35 publications

LASSO-Based Identification of Risk Factors and Development of a Prediction Model for Sepsis Patients

LASSO-Based Identification of Risk Factors and Development of a Prediction Model for Sepsis Patients

Successful Application of a Hemoperfusion Machine in Separated System CRRT: Evaluating Effectiveness and Safety in Critically Ill Patients With AKI in Resource‐Limited Settings

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