Renal replacement therapy for diabetic end-stage renal disease: Data from 10 registries in Europe (1991–2000)

Dijk, Paul C. W. van; Jager, Kitty J.; Stengel, Bénédicte; Grönhagen‐Riska, Carola; Feest, Terry; Briggs, J. D.

doi:10.1111/j.1523-1755.2005.00227.x

Cited by 149 publications

(103 citation statements)

References 22 publications

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“…18 Serum albumin is a strong predictor of mortality 11,12 and related to nutritional and inflammatory status. 19 Epidemiologic studies have confirmed that low serum albumin levels are frequent in HD patients, the prevalence being nearly unchanged in the past decade.…”

Section: Discussionmentioning

confidence: 99%

Effect of Membrane Permeability on Survival of Hemodialysis Patients

Locatelli¹,

Martín‐Malo²,

Hannedouche³

et al. 2009

Journal of the American Society of Nephrology

361

279

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The effect of high-flux hemodialysis membranes on patient survival has not been unequivocally determined. In this prospective, randomized clinical trial, we enrolled 738 incident hemodialysis patients, stratified them by serum albumin Յ4 and Ͼ4 g/dl, and assigned them to either low-flux or high-flux membranes. We followed patients for 3 to 7.5 yr. Kaplan-Meier survival analysis showed no significant difference between high-flux and low-flux membranes, and a Cox proportional hazards model concurred. Patients with serum albumin Յ4 g/dl had significantly higher survival rates in the high-flux group compared with the low-flux group (P ϭ 0.032). In addition, a secondary analysis revealed that high-flux membranes may significantly improve survival of patients with diabetes. Among those with serum albumin Յ4 g/dl, slightly different effects among patients with and without diabetes suggested a potential interaction between diabetes status and low serum albumin in the reduction of risk conferred by high-flux membranes. In summary, we did not detect a significant survival benefit with either high-flux or low-flux membranes in the population overall, but the use of high-flux membranes conferred a significant survival benefit among patients with serum albumin Յ4 g/dl. The apparent survival benefit among patients who have diabetes and are treated with high-flux membranes requires confirmation given the post hoc nature of our analysis. 20: 645-654, 200920: 645-654, . doi: 10.1681 Patients who have stage 5 chronic kidney disease (CKD) and are on dialysis therapy have a high mortality rate, estimated between 14 and 26% in Europe and at 24% per year in the United States. 1 The accumulation of various retention solutes over a broad range of molecular weights and chemical composition is involved in the complex pathophysiology of uremia and, among other factors, implicated in the high mortality observed in CKD. 2 Because of their higher porosity, high-flux hemodialysis (HD) membranes have the capacity to remove retention solutes of higher molecular weight than do low-flux membranes, 3 which contain smaller pores. Whether this enhanced solute elimination of high-flux membranes translates J Am Soc Nephrol

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Section: Discussionmentioning

confidence: 99%

Effect of Membrane Permeability on Survival of Hemodialysis Patients

Locatelli¹,

Martín‐Malo²,

Hannedouche³

et al. 2009

Journal of the American Society of Nephrology

361

279

View full text Add to dashboard Cite

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“…Another possible contributory factor is a longer life expectancy of ESRD patients compared with the past. 5,6 GN is the most commonly recognized cause of ESRD worldwide. 7,8 In our study, the underlying cause of ESRD was unclear in the majority of the patients.…”

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confidence: 99%

One-year survival rate of renal transplant: factors influencing the outcome

Rezapour¹,

Yarmohammadi²,

Tavakkoli³

2017

TRRM

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Background: Renal transplantation remains the treatment of choice for end-stage renal disease, as the procedure not only improves quality of life, but also markedly increases patients' survival rates. Organ and patient survival rates are important issues of interest post-transplantation. Aim: To determine the 1-year survival rate of renal transplant, we studied graft function, which is a predictor of survival, among those who received a kidney transplant in the time period between February 2012 and February 2013 at Montaserie Organ Transplantation Hospital. Materials and methods: This is a retrospective cohort study planned to determine patient and organ survival rates after kidney transplantation from living and deceased donors during a 1-year period. We also tried to clarify factors resulting in graft loss. Designated variables were collected using checklists and subsequently entered into SPSS software version 17 and analyzed using the Kaplan-Meier method and descriptive statistics. Results: From 173 patients included in the study, 67.1% (n=116) were female. The mean age of the recipients was 33±12.85 years. In the majority of cases, cause of end-stage renal disease was not clear (n=89, 51.44%). Urinary tract infection (23.1%) was the commonest post-operative complication, followed by delayed graft function, which was diagnosed in 22 (12.7%) recipients. Seventeen cases of graft rejection (9.8%) were recorded and 4 (2.3%) of these cases underwent nephrectomy that will be regarded as graft loss in this paper. Therefore, 1-year graft survival was 90.2%. Graft survival in cadaveric and live-donor recipients was 90.8% and 88.7%, respectively. As there was no mortality reported among graft recipients, 1-year patient survival rate was 100%. It was found that graft rejection was marginally, but not significantly, higher with female donors. (p=0.05). Conclusion: One-year graft survival in our cohort was comparable with reports from the large centers in the world. Female donor can be a possible negative factor for graft outcome.

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“…7 During the past decade, the number of elderly patients and patients who had diabetes and received renal replacement therapy (RRT) increased rapidly. [3][4][5][6][7][8][9] Population aging, increased prevalence of diabetes, improved management of cardiovascular diseases, and improved access to RRT may explain this evolution. [3][4][5][6][7][8][9] In dialyzed patients, survival after first RRT in the incident cohort is usually analyzed using survival curves drawn by Kaplan-Meier or actuarial methods 10 and using Cox regression in multivariate analysis.…”

mentioning

confidence: 99%

Effect of Age, Gender, and Diabetes on Excess Death in End-Stage Renal Failure

Villar

Remontet

Labeeuw

et al. 2007

Journal of the American Society of Nephrology

150

117

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Life expectancy is short in elderly individuals with end-stage renal failure (ESRF). This study aimed to compare mortality in patients with ESRF versus the general population (GP) to assess the evolution of excess mortality by age, gender, nephropathy, and dialysis modality after first dialysis. All incident adult dialysis patients from January 1,1999, to December 31, 2003, who lived in Rhô ne-Alpes Region (France) were included and followed up to death or December 31, 2005. Standardized mortality ratios (SMR) in comparison with GP were computed in the first to the fifth years after first dialysis. In the whole cohort (3025 incident patients), SMR decreased during these 5 yr from 7.4 to 5.2 (P ϭ 0.002). In the 18-to 44-, 45-to 64-, 65-to 74-, 75-to 84-, and Ն85-yr-old groups, SMR decreased from 26.7 to 6.2 (P ϭ 0.01), from 12.8 to 8.1 (P ϭ 0.03), from 8.6 to 5.6 (P ϭ 0.051), from 7.1 to 4.5 (P ϭ 0.02), and from 3.5 to 1.2 (P ϭ 0.14), respectively. Among age categories, differences were significant in the first 3 yr (P Ͻ 0.05). SMR were higher 1.5-fold in women than in men in the first 4 yr (P Ͻ 0.05). In patients with diabetic nephropathy (DN), SMR increased during the first 3 yr (P ϭ 0.045) and were higher than in patients without DN in the second, third, and fourth years (P Ͻ 0.05). SMR were higher in the peritoneal dialysis than in the hemodialysis group in the fourth year (P Ͻ 0.01). Patients with ESRF have a high excess mortality compared with the GP. Older patients with ESRF experienced less excess mortality. ESRF cancels out women's survival advantage noted in the GP. SMR evolution in patients with DN was different from that in patients without DN.

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Renal replacement therapy for diabetic end-stage renal disease: Data from 10 registries in Europe (1991–2000)

Cited by 149 publications

References 22 publications

Effect of Membrane Permeability on Survival of Hemodialysis Patients

Effect of Membrane Permeability on Survival of Hemodialysis Patients

One-year survival rate of renal transplant: factors influencing the outcome

Effect of Age, Gender, and Diabetes on Excess Death in End-Stage Renal Failure

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