Renal redox dysregulation in AKI: application for oxidative stress marker of AKI

Kasuno, Kenji; Shirakawa, Kiichi; Yoshida, Haruyoshi; Mori, Kiyoshi; Kimura, Hideki; Takahashi, Naoki; Nobukawa, Yasunari; Shigemi, Kenji; Tanabe, Sawaka; Yamada, Narihisa; Koshiji, Takaaki; Nogaki, Fumiaki; Kusano, Hitoshi; Ono, Takahiko; Uno, Kazuko; Nakamura, Hajime; Yodoi, Junji; Muso, Eri; Iwano, Masayuki

doi:10.1152/ajprenal.00381.2013

Cited by 34 publications

(31 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, it has been attributed to an anti-inflammatory role besides suppression of apoptosis and fostering cell growth [32, 81–83]. Trx can interact with immune cells and facilitates the production of TNF- α [31, 84] by monocytic lineage, but it is also able to counteract the production of inflammatory cytokines such as TNF- α [85, 86].…”

Section: Discussionmentioning

confidence: 99%

Multifunctional Thioredoxin-Like Protein from the Gastrointestinal Parasitic NematodesStrongyloides rattiandTrichuris suisAffects Mucosal Homeostasis

Ditgen

Anandarajah

Hansmann

et al. 2016

Journal of Parasitology Research

View full text Add to dashboard Cite

The cellular redox state is important for the regulation of multiple functions and is essential for the maintenance of cellular homeostasis and antioxidant defense. In the excretory/secretory (E/S) products of Strongyloides ratti and Trichuris suis sequences for thioredoxin (Trx) and Trx-like protein (Trx-lp) were identified. To characterize the antioxidant Trx-lp and its interaction with the parasite's mucosal habitat, S. ratti and T. suis Trx-lps were cloned and recombinantly expressed. The primary antioxidative activity was assured by reduction of insulin and IgM. Further analysis applying an in vitro mucosal 3D-cell culture model revealed that the secreted Trx-lps were able to bind to monocytic and intestinal epithelial cells and induce the time-dependent release of cytokines such as TNF-α, IL-22, and TSLP. In addition, the redox proteins also possessed chemotactic activity for monocytic THP-1 cells and fostered epithelial wound healing activity. These results confirm that the parasite-secreted Trx-lps are multifunctional proteins that can affect the host intestinal mucosa.

show abstract

Section: Discussionmentioning

confidence: 99%

Multifunctional Thioredoxin-Like Protein from the Gastrointestinal Parasitic NematodesStrongyloides rattiandTrichuris suisAffects Mucosal Homeostasis

Ditgen

Anandarajah

Hansmann

et al. 2016

Journal of Parasitology Research

View full text Add to dashboard Cite

show abstract

“…The AKI pathogenesis is deeply complex as a result of many insults, as well as the involvement of different individual and overlapping pathophysiological pathways. Accordingly, many different molecular mechanisms have been implicated in the pathogenesis of AKI, although kidney injury caused by reactive oxygen species (ROS) is recognized as one of the fundamental principles (Kasuno et al 2014;Virzi et al 2015;Pavlakou et al 2017). ROS may injure the kidney in multiple ways.…”

Section: Introductionmentioning

confidence: 99%

Elevated Serum Ferritin Levels Are Predictive of Renal Function Recovery among Patients with Acute Kidney Injury

Dimitrijević

Šalinger-Martinović

Janković

et al. 2019

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Oxidative stress (OS) frequently contributes to the development of acute kidney injury (AKI). Iron can promote oxidative stress and tissue injury by catalyzing free reactive oxygen species (ROS) generation and increasing the steady-state concentration of these potent oxidants. The anticipated role of ferritin is to protect from OS by sequestering iron and limiting its involvement in reactions that generate ROS. In this prospective study, we aimed to investigate the association between serum ferritin levels and kidney function recovery among patients with AKI. Renal recovery was determined as a return of serum creatinine to less than 1.25 times the baseline value after 90 days of follow-up. One hundred twelve patients (72 males and 40 females, 63.68 ± 10.6 years old) were included in the final analysis. They were divided into AKI recovery (n = 76) and non-recovery groups (n = 36). Ferritin levels on admission were higher in AKI recovery group [284 (IQR 153-525) ng/mL] compared with the non-recovery group [127.4 (IQR 30-243) ng/mL], p < 0.001. Serum ferritin levels and the renal recovery significantly positively correlated (r = 0.72, p < 0.001). In multiple linear regression analysis, higher serum ferritin was associated with renal function recovery (OR 3.68, CI 2.02-3.97, p < 0.001). The optimal cut-off point of 240.5 ng/mL was determined for serum ferritin, which showed a sensitivity of 75.8% and a positive predictive value of 90%. In conclusion, serum ferritin levels on admission may be used as a prognostic marker for predicting renal recovery in AKI patients.

show abstract

“…[3][4][5][6] In addition, oxidative stress is an important determinant of acute kidney failure. 7,8 In some studies, ROS has been advanced as a factor in the pathogenesis of both ischemic and nephrotoxic kidney damage. [9][10][11][12] The antioxidant defense enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) play important roles in protecting cells from free oxygen radical damage.…”

Section: Introductionmentioning

confidence: 99%

Manganese superoxide dismutase, glutathione peroxidase and catalase gene polymorphisms and clinical outcomes in acute kidney injury

Kıdır

Yiğit

et al. 2016

Renal Failure

View full text Add to dashboard Cite

Introduction The aim of this study was to evaluate the potential association of single gene polymorphisms of manganese superoxide dismutase (MnSOD), glutathione peroxidase 1 (GPX1) and catalase (CAT) with clinical outcomes of acute kidney injury (AKI). Materials and methods Ninety AKI patients and 101 healthy volunteers were included in the study. Determination of MnSOD rs4880, GPX1 rs1050450 and CAT rs769217 polymorphisms was performed using real-time polymerase chain reaction amplification. The duration of hospitalization of AKI patients, dialysis and intensive care requirements, sepsis, oliguria and in-hospital mortality rates were assessed. Results The MnSOD, GPX1 and CAT genotypes and allele frequencies of AKI patients did not differ significantly from those of healthy controls. In patients with a T allele in the ninth exon of the CAT gene, intensive care requirements were greater than those of patients with the CC genotype (p ¼ 0.04). In addition, sepsis and in-hospital mortality were observed significantly more frequently in patients with a T allele in the ninth exon of the CAT gene (p ¼ 0.03). Logistic regression analysis determined that bearing a T allele was the primary determinant of intensive care requirements and in-hospital mortality, independent of patient age, gender, presence of diabetes and dialysis requirements (OR 6.10, 95% CI 1.34-27.81, p ¼ 0.02 and OR 10.25, 95% CI 1.13-92.80, p ¼ 0.04, respectively). Conclusion Among AKI patients in the Turkish population, hospital morbidity and mortality were found to be more frequent in patients bearing a T allele of the rs769217 polymorphism of the CAT gene.

show abstract

Renal redox dysregulation in AKI: application for oxidative stress marker of AKI

Cited by 34 publications

References 26 publications

Multifunctional Thioredoxin-Like Protein from the Gastrointestinal Parasitic NematodesStrongyloides rattiandTrichuris suisAffects Mucosal Homeostasis

Multifunctional Thioredoxin-Like Protein from the Gastrointestinal Parasitic NematodesStrongyloides rattiandTrichuris suisAffects Mucosal Homeostasis

Elevated Serum Ferritin Levels Are Predictive of Renal Function Recovery among Patients with Acute Kidney Injury

Manganese superoxide dismutase, glutathione peroxidase and catalase gene polymorphisms and clinical outcomes in acute kidney injury

Contact Info

Product

Resources

About