Renal radiopharmaceuticals—An update

Chervu, L. Rao; Blaufox, M. Donald

doi:10.1016/s0001-2998(82)80038-x

Cited by 73 publications

(17 citation statements)

References 121 publications

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“…One of the important characteristics of this ligand is that it allows functionalization via the carboxylic functional groups simply by using the DTPA-bisanhydride as a precursor (15,23). The DTPA amide derivatives (either bisamides or monoamide) possess the same number of donor atoms (three nitrogens and five oxygens) as DTPAH 5 , with a reduction of ionizable groups. These acyclic ligands have some advantages relative to macrocyclic analogues in biomedical applications because of their much higher complexation rates and their higher flexibility in coordinating cations compared to the macrocyclic compounds, although their generally faster dissociation kinetics and lower thermodynamic stability can constitute serious disadvantages (27).…”

Section: Introductionmentioning

confidence: 99%

Characterization of 111In3+ complexes of DTPA amide derivatives: biodistribution and clearance studied by gamma imaging

Prata

Santos

Bligh

et al. 2000

Nuclear Medicine and Biology

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A large series of structurally related diethylenetriaminepentaacetic acid amide derivatives with different structures and lipophilic properties were synthesized and radiolabeled with (111)In(3+). Two of the more hydrophobic compounds studied ([(111)In]L(9) and [(111)In]L(10)) showed high affinity for human serum albumin (HSA). The biodistribution and clearance properties shown by all complexes upon injection in Wistar rats were followed by gamma imaging. The blood retention time of the chelates correlates better with their binding to HSA than with their hydrophilic/lipophilic ratio. Hydrophilic and negatively charged complexes undergo renal retention, while the majority of the lipophilic complexes are retained in the blood for a longer period of time and are cleared through the liver.

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Section: Introductionmentioning

confidence: 99%

Characterization of 111In3+ complexes of DTPA amide derivatives: biodistribution and clearance studied by gamma imaging

Prata

Santos

Bligh

et al. 2000

Nuclear Medicine and Biology

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“…In addition to the weight of a kidney to be transplanted, in the present study, we measured D-FRV and D-SKGFR for size matching. Traditionally, Tc-99m DMSA scintigraphy has been used to detect renal cortical defects, as it may be used for the functional imaging of the proximal tubular mass of renal cortex [16,17,18,19]. The uptake of Tc-99m DMSA is dependent on renal blood flow and on the membrane transport function of proximal renal tubular cells, and is known to be well correlated with effective renal plasma flow, GFR, and creatinine clearance.…”

Section: Discussionmentioning

confidence: 99%

Measurement of Donor Kidney Functional Renal Volume and Glomerular Filtration Rate to Predict Allograft Function during the Post-Transplantation Period

Huh¹,

Yun²,

Kim³

et al. 2009

Nephron Clin Pract

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Background: We measured donor kidney weight (D-KW), functional renal volume (D-FRV), and single-kidney glomerular filtration rate (D-SKGFR), and then evaluated the impact of the indices to recipient body weight (R-BW) on graft function. Methods: This study included 44 recipients of live donor transplants without delayed graft function or acute rejection within 2 years of transplantation. Results: There was a statistically significant difference in serum creatinine between recipients with a D-KW/R-BW ratio of ≤4.25, D-FRV/R-BW ratio of ≤5.14, or D-SKGFR/R-BW ratio of ≤1.06 and recipients with a D-KW/R-BW ratio of >4.25, D-FRV/R-BW ratio of >5.14, or D-SKGFR/R-BW ratio of >1.06, respectively. D-KW/R-BW, D-FRV/R-BW, and D-SKGFR/R-BW strongly correlated with serum creatinine at 1 year and 2 years post-transplantation. In multivariate analysis, D-FRV and donor age were statistically significant risk factors which influenced serum creatinine at 1 year and 2 years post-transplantation. Conclusion: D-FRV/R-BW and donor age have significant impact on graft function. D-FRV/R-BW can be measured ahead of surgery. Therefore, measuring the D-FRV is useful to select a more optimal donor kidney among otherwise similar candidates during preoperative evaluation to improve posttransplant graft function.

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“…Numerous studies in adult and paediatric patients with a wide range of renal function levels have shown a close agreement between the renal plasma clearance of I3'I-Diatrizoate, '311-Iothalamate and '2'I-Iothalamate on the one hand, and that of inulin determined by the classical clearance technique on the other (Skov, 1970;Bianchi, 1972;Chervu & Blaufox, 1982). Since the extrarenal excretion of "'I-Diatrizoate increases with falling GFR, a single injection 13'I-Diatrizoate plasma clearance determined without urine sampling is considered unreliable for accurate GFR measurements (Chamberlain & Sherwood, 1966;Nelson, Brown & Culp, 1973;Bianchi, Donadio & Tramonti, 1981).…”

Section: J Br@chner-mortensenmentioning

confidence: 89%

“…Hardly any of the presently most commonly used indicator substances completely satisfy both requirements at all GFR values, for example, inulin (polyfructusan); the urological contrast agents Diatrizoate and Iothalamate labelled with either I3II or Iz51; and the metal chelates Ethylenediaminetetraacetic acid (EDTA) and Diethylenetriaminepentaacetic acid (DTPA) labelled with 5'Cr and 9ymTc respectively. They all have some extra-renal elimination which in most cases is considered insignificant, but there are only a few studies in man on the distribution and excretion routes for most of these indicator substances at various degrees of renal impairment (Chervu, Freeman & Blaufox, 1974;Chervu & Blaufox, 1982).…”

Section: J Br@chner-mortensenmentioning

confidence: 99%