Measurement of Donor Kidney Functional Renal Volume and Glomerular Filtration Rate to Predict Allograft Function during the Post-Transplantation Period

Huh, Kyu Ha; Yun, Mijin; Kim, Tae Sung; Cho, Arthur; Lee, Jong Doo; Myoung, Sung Min; Kim, Yu Seun; Kim, Myoung Soo

doi:10.1159/000235251

Cited by 12 publications

(5 citation statements)

References 34 publications

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“…Of the 351 recipients, 208 were men and 143 were women. The mean age of the recipients was 37 yr (median, 38; interquartile range [IQR], 27-48), and the mean age of the donors was 38 yr (median, 38; IQR, [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46]. All transplants were ABO compatible.…”

Section: Baseline Characteristics Of Recipients and Donorsmentioning

confidence: 99%

Graft volume as the surrogate marker for nephron number affects the outcomes of living‐donor kidney transplantation

Han

Yang

et al. 2011

Clinical Transplantation

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Post-transplant outcome of kidney allografts depends on various factors, one of which may be the compatibility in volume between graft and recipient. However, previous studies adjusted the graft volume only for recipient's size. As the adjusted graft volume for donor's size would be substituted of nephron number more accurately, we adjusted the graft volume for both recipient's and donor's sizes. In 351 cases of living-donor kidney transplantation, we found that the adjusted graft volume for both recipient's and donor's body surface areas (BSAs) yielded larger area under the curves for the transplant outcomes than looking only at the adjusted volume for the recipient's BSA. The recipients were separated into two groups according to the low and high adjusted graft volumes. During the follow-up period (mean 55.6 months), the low-graft-volume group conferred greater risk of rejection, chronic change, glomerulonephritis, and graft loss than the high-graft-volume group (all p's < 0.05). However, the frequency of T-cell infiltration, as evaluated in protocol biopsy, was not different between the two adjusted graft volume groups. In conclusion, the graft volume as the surrogate marker for nephron number should be considered in kidney transplantation, especially in otherwise similar donor conditions.

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Section: Baseline Characteristics Of Recipients and Donorsmentioning

confidence: 99%

Graft volume as the surrogate marker for nephron number affects the outcomes of living‐donor kidney transplantation

Han

Yang

et al. 2011

Clinical Transplantation

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“…Kidney volume as a surrogate marker of nephron mass and renal function has been presented by many authors as a good predictor of recipient renal function. Many studies to date have investigated donor factors associated with recipient renal function and outcomes, though scarce data are available about factors associated with donor's renal function after nephrectomy [9‐16].…”

Section: Introductionmentioning

confidence: 99%

Remaining kidney volume indexed to weight as a strong predictor of estimated glomerular filtration rate at 1 year and mid‐term renal function after living‐donor nephrectomy ‐ a retrospective observational study

et al. 2020

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The donors' estimated glomerular filtration rate (eGFR) after living nephrectomy has been a concern, particularly in donors with smaller kindeys. Therefore, we developed this retrospective observational study in 195 donors to determine the ability remaining kidney volume indexed to weight (RKV/W) to predict eGFR at 1 year through multivariate linear regression and to explore this relationship between annual eGFR change from 1 to 4 years postdonation evaluated by a linear mixed model. Comparing RKV/W tertiles (T1, T2, T3), RKV/W was a good predictor of 1year eGFR which was significantly better in T3 donors. Gender, predonation eGFR, and RKV/W were independent predictors of eGFR at 1-year. In a subgroup with predonation eGFR < 90mL/min/1.73 m 2 , a significant prediction of eGFR < 60mL/min/1.73 m 2 was detected in males with RKV/ W ≤ 2.51cm 3 /kg. Annual eGFR (ml/min/year) change from 1 to 4 years was + 0.77. RKV/W divided by tertiles (T1-T3) was the only significant predictor: T2 and T3 donors had an annual eGFR improvement opposing to T1. RKV/W was a good predictor of eGFR at 1 year, independently from predonation eGFR. A higher RKV/W was associated with improved eGFR at 1 year. A decline in eGFR on the four years after surgery was only noticeable in donors with RKV/W ≤ 2.13cm 3 /kg.

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“…In comparison with HugenÕs findings, simple recipient BSA was not an impact factor on the graft function but donor age and the ratio of kidney volume to recipient BSA were in this study. Huh et al (33) have reported that the ratio of functional renal volume, which could be obtained using a gamma camera, to recipient body weight and donor age had significant impacts on graft function. On the contrary, it has been reported that CT might be more accurate in determining GFR than gamma camera imaging because CT allows a more precise determination of the region of interest because of the lack of background artifacts (29).…”

Section: Discussionmentioning

confidence: 99%

Impact of the ratio of graft kidney volume to recipient body surface area on graft function after live donor kidney transplantation

Lee

Won

2011

Clinical Transplantation

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Lee JH, Won JH, Oh C‐K. Impact of the ratio of graft kidney volume to recipient body surface area on graft function after live donor kidney transplantation.  Clin Transplant 2011: 25: E647–E655. © 2011 John Wiley & Sons A/S. Abstract: Functioning nephron mass is a determinant of the graft function of kidney transplant recipients. The graft kidney volume and its weight have been reported to be surrogates of the nephron mass. To investigate the impact of the ratios of the surrogates to recipient body surface area (BSA) and body weight on the graft function within six months post‐transplantation, we measured the graft kidney volume, using computed tomography with 3‐dimensional reconstruction before transplantation, and measured the graft kidney weight during surgery. Ninety‐four cases of live donor kidney transplants were included in this study. The graft kidney volume/recipient BSA ratio was correlated with the glomerular filtration rate (GFR) of recipients at one and six months post‐transplantation (r = 0.416, p < 0.001 and r = 0.381, p < 0.001, respectively). We found a difference in the graft function between recipients with a graft kidney volume/recipient BSA ratio of ≥90.9 mL/m2 and those with a ratio of <90.9 mL/m2 (p < 0.001). Multivariate analysis demonstrated that the graft kidney volume/recipient BSA ratio and donor age are independent predictors of recipient GFR at one and six months post‐transplantation (p < 0.05). During living donor and recipient matching, both the potential volume of the donated kidney and the body size of recipient should be considered.

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Measurement of Donor Kidney Functional Renal Volume and Glomerular Filtration Rate to Predict Allograft Function during the Post-Transplantation Period

Cited by 12 publications

References 34 publications

Graft volume as the surrogate marker for nephron number affects the outcomes of living‐donor kidney transplantation

Graft volume as the surrogate marker for nephron number affects the outcomes of living‐donor kidney transplantation

Remaining kidney volume indexed to weight as a strong predictor of estimated glomerular filtration rate at 1 year and mid‐term renal function after living‐donor nephrectomy ‐ a retrospective observational study

Impact of the ratio of graft kidney volume to recipient body surface area on graft function after live donor kidney transplantation

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