Renal Pelvis Squamous Cell Carcinoma and Renal Cell Carcinoma in a Tuberculous Kidney

Al-Assiri, Mana; Alotaibi, Mohammed; Sircar, Kanishka; Laplante, Michael P.

doi:10.1100/tsw.2004.196

Cited by 5 publications

(5 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SCC is highly aggressive tumor with the poorest prognosis among histological subtypes of renal pelvis tumors, with a median survival of 3.5 months. 2 That points to the need for a careful examination with imaging modalities like contrast enhanced CT.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hydronephrotic Kidney Previously Treated for Tuberculosis: Rare Primary Squamous Cell Carcinoma of Renal Pelvis Diagnosed by Fine-needle Aspiration Cytology

Obad-Kovačević

Kardum-Skelin

Kaić

et al. 2015

Urology Case Reports

View full text Add to dashboard Cite

Primary squamous cell carcinoma (SCC) of the renal pelvis is a very rare tumor often associated with renal calculi and chronic infections. There are only a few articles in literature which report renal pelvis SCC in kidneys treated for renal tuberculosis, diagnosed after nephrectomy. We report the case of SCC in a hydronephrotic kidney previously treated for tuberculosis, diagnosed by ultrasound (US)-guided fine-needle aspiration cytology (FNAC), prior to core biopsy and nephrectomy. Our report highlights the utility of FNAC and the need for a careful search for renal collecting system tumors, in patients previously treated for renal tuberculosis.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Primary tumors of the renal collecting system are rare, accounting for only 4–5% of all urothelial tumors. 1 , 2 Primary squamous cell carcinoma (SCC) of the renal pelvis is a very rare tumor accounting for only 0.5–0.8% of malignant renal tumors. 3 SCC is often associated with chronic renal calculi and chronic infections.…”

Section: Introductionmentioning

confidence: 99%

Hydronephrotic Kidney Previously Treated for Tuberculosis: Rare Primary Squamous Cell Carcinoma of Renal Pelvis Diagnosed by Fine-needle Aspiration Cytology

Obad-Kovačević

Kardum-Skelin

Kaić

et al. 2015

Urology Case Reports

View full text Add to dashboard Cite

show abstract

“…Squamous cell carcinoma accounts about 1% of renal neoplasms. A few cases of concomitant renal cell carcinoma and transitional cell carcinoma have been reported [ 2 - 4 ]. The simultaneous occurrence of renal cell carcinoma and squamous cell carcinoma is excepcional.…”

Section: Discussionmentioning

confidence: 99%

“…The first case was reported by Elsa Valderrama et al in 1987. Subsequently, Charles et al described the association of renal squamous carcinoma and cystic renal cell carcinoma [ 3 ] and renal pelvis squamous cell carcinoma with renal cell carcinoma in a tuberculous kidney [ 4 ]. Likewise has been reported association of renal cell carcinoma with another renal cell neoplasms (conventional renal cell carcinoma, oncocytoma, collecting duct carcinoma) and cases with sarcomatoid transformation [ 5 , 6 ] or extensive calcification with ossification [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Chromophobe renal cell carcinoma and squamous renal cell carcinoma

et al. 2007

View full text Add to dashboard Cite

Chromophobe renal cell carcinoma (CHRC) is a neoplasm of the kidney with clinicopathologic peculiarities that seems to be of better prognosis than conventional renal cell carcinoma. Classical and eosinophilic types are the two histological variants recorded. Also, it has been described in association with carcinoma of collecting ducts, conventional renal cell carcinoma and sarcomatoid renal cell carcinoma. Squamous renal carcinoma is a very rare neoplasm with a malignant course. We describe a case of simultaneous chromophobe renal cell carcinoma with squamous cell carcinoma, finding which, to the best of our knowledge, has not previously been reported.

show abstract

“…SCC of urothelial tract is thought to arise through a process of squamous metaplasia of urothelium (7). It may be triggered by chronic irritation and infection such as polycystic kidney disease (7), prolonged use of immunosuppressants (8,9), chronic inflammation (10)(11)(12)(13)(14)(15)(16)(17)(18), kidney stones (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29), and horseshoe kidney (25,(30)(31)(32)(33)(34). Early symptoms are atypical including recurrent urinary infections, ongoing pyuria, hematuria or backache.…”

Section: Introductionmentioning

confidence: 99%

A case report of complete pathological remission after chemotherapy in a patient with primary renal squamous cell carcinoma

Yu¹,

Lan²,

Li³

et al. 2021

Transl Androl Urol

View full text Add to dashboard Cite

This is the first case report of the outcomes of systemic chemotherapy in a patient with locally advanced renal squamous cell carcinoma, a rare tumor, as well as the first next generation sequencing study of this rare tumor. The patient's main symptoms were fever and low back pain. Initial positron emission tomography and computed tomography (PET-CT) suggested a malignant renal tumor at onset, but biopsy confirmed renal squamous cell carcinoma. Next generation sequencing showed a low level of microsatellite instability (MSI-L), a high tumor mutational burden (TMB-H), a high neoantigen burden (TNB-H), and a strong loss of heterozygosity (LOH) for human leukocyte antigen (HLA), with 67 deleterious mutations.The patient achieved partial radiological remission after a cycle of systemic chemotherapy with albuminbound paclitaxel combined with nedaplatin. After radical resection of the left renal tumor, postoperative pathology confirmed complete tumor remission and tumor-like xanthogranulomatous pyelonephritis.Conclusion: This renal squamous cell carcinoma patient responded to systemic chemotherapy with paclitaxel combined with platinum, providing a reference for the future treatment of similar cases. Pathology and gene sequencing indicated that renal squamous cell carcinoma occurred in a background of active inflammation and that the tumor evolved immune escape mechanisms such as loss of HLA heterozygosity, with gene repair defects and TMB-H.

show abstract

Renal Pelvis Squamous Cell Carcinoma and Renal Cell Carcinoma in a Tuberculous Kidney

Cited by 5 publications

References 3 publications

Hydronephrotic Kidney Previously Treated for Tuberculosis: Rare Primary Squamous Cell Carcinoma of Renal Pelvis Diagnosed by Fine-needle Aspiration Cytology

Hydronephrotic Kidney Previously Treated for Tuberculosis: Rare Primary Squamous Cell Carcinoma of Renal Pelvis Diagnosed by Fine-needle Aspiration Cytology

Simultaneous Chromophobe renal cell carcinoma and squamous renal cell carcinoma

A case report of complete pathological remission after chemotherapy in a patient with primary renal squamous cell carcinoma

Contact Info

Product

Resources

About