Renal oncocytomatosis in a long‐term hemodialysis patient treated by laparoscopic surgery

Shiga, Yoshiyuki; Suzuki, Koichiro; Tsutsumi, Masahiro; Ishikawa, Satoshi; Gotoh, Michihiro; Shimokama, Tatsuro; Hattori, Kazunori

doi:10.1046/j.1442-2042.2002.00528.x

Cited by 11 publications

(7 citation statements)

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“…The previously reported cases are summarized in Table 2 2,3,8,11–16 . The ages of the patients ranged between 12 and 76 years old (mean 55.5 years old).…”

Section: Discussionmentioning

confidence: 99%

Renal oncocytosis

Nagashima

Mitsuya

Shioi

et al. 2005

Pathology International

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Renal oncocytosis is a rare disorder in which numerous oncocytic nodules develop in the kidney. An additional case is reported here. The patient was a 51-year-old woman who had received hemodialysis for 27 years. Nineteen years previously she had developed a tumorous lesion in the right kidney, which had been diagnosed as oncocytoma with laparotomic biopsy. Recently the kidney was removed because of enlargement of the tumor. The renal parenchyma was entirely replaced with numerous brownish nodules. Histologically, the nodules were composed of nests of uniform oncocytic cells. Ultrastructurally, the oncocytic cells contained numerous mitochondria. Immunohistochemical features of the nodules were identical to those of sporadic oncocytomas, that is, immunophenotypes similar to the distal nephron and reactivity with antimitochondrial antigen. Based on these findings, the lesion was diagnosed as renal oncocytosis. It was not possible to determine whether the larger nodules should be diagnosed as oncocytoma or a part of oncocytosis. Additionally, the germ line mutation of the Birt-Hogg-Dubé (BHD) syndrome gene was examined using the genomic DNA obtained from the peripheral lymphocytes, which failed to show any gene alteration. Despite the rare occurrence pathologists and urologists should be aware of renal oncocytosis, as a precursor lesion of renal oncocytoma and chromophobe renal cell carcinoma.

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“…The previously reported cases are summarized in Table 2 2,3,8,11–16 . The ages of the patients ranged between 12 and 76 years old (mean 55.5 years old).…”

Section: Discussionmentioning

confidence: 99%

Renal oncocytosis

Nagashima

Mitsuya

Shioi

et al. 2005

Pathology International

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“…Esta es una entidad descrita en 1982 por Warfel and Eble 22 , que encontraron más de doscientos focos de oncocitoma en un paciente, de manera bilateral. Desde entonces se han descrito muy escasos casos similares, alguno de ellos de forma unilateral y otros, al igual que en el nuestro, en pacientes sometidos a diálisis durante largo tiempo [23][24][25] . Para algunos autores esta entidad podría entenderse como el paso siguiente a una hiperplasia oncocítica nodular multifocal de asiento renal.…”

Section: Discusionunclassified

Oncocitoma renal: Revisión de nuestra serie de 22 pacientes

et al. 2006

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RESUMENONCOCITOMA RENAL. REVISIÓN DE NUESTRA SERIE DE 22 PACIENTES. Introducción: El oncocitoma renal es un tumor benigno cuya frecuencia de presentación oscila entre el 3-7% de las masas renales sólidas. Muestra especiales características celulares y evolutivas, con posibilidad de metacronicidad, bilateralidad y multifocalidad, además de un difícil diagnóstico diferencial con neoplasias malignas.Material y Método: Revisamos retrospectivamente en 428 tumores renales intervenidos desde Enero de 1986 hasta Abril de 05 la proporción de oncocitomas diagnosticados, analizando sus características anatomopatoló-gicas y comportamiento clínico, comparándolas con las presentadas por los carcinomas de células renales. Observamos su posible bilateralidad, multifocalidad y asociación con otros tumores. Determinamos en cuán-tos casos los métodos diagnósticos de imagen permitieron sospechar la naturaleza tumoral benigna previamente a la intervención. Seguimiento medio y mediano 13 y 36,86 meses respectivamente .Resultados: Hemos encontrado 24 oncocitomas (5,67%), en 10 hombres y 12 mujeres con una edad media de 59 años (34-84). 12 de ellos en riñón izquierdo y 12 en derecho, además de una oncocitomatosis renal. Tamaño medio de 4,64 cm (1-12,5). En 17 pacientes el diagnóstico ha sido incidental. En los 5 restantes el sín-toma de debut fue hematuria. Supervivencia específica 100%. Se sospechó la naturaleza tumoral benigna o específicamente oncocitomatosa previamente a la cirugía en 22,73% (5/22) y 9,9% (2/22) respectivamente.Conclusiones: En nuestra serie de tumores renales intervenidos el porcentaje de oncocitomas coincide con lo publicado en la literatura. Hemos encontrado dos casos de tumor sincrónico, pero ninguno metacrónico, bilateral ni metastásico. Todos han presentado un comportamiento benigno.Palabras clave: Oncocitoma renal. Neoplasias renales. Tumor renal benigno. ABSTRACTRENAL ONCOCYTOMA. REVIEW OF OUR 22 PATIENTS Summary: Renal oncocytoma (OR) is a benign tumor. It may represent up to 3-7% of solid kidney masses, and shows specifics cellular and evolutive characteristics. Metacronicity, multifocality and bilateralism has been reported. Materials and methods: Between 1986 and 2005, 478 kidney tumors have been surgically treated at our institution. We report the frequency and characteristics of OR in our patients, compared with renal cell carcinomas (RCC). We try to find out the rate of multifocality, bilateralism and other tumor association, and the number of neoplasms originally diagnosed as OR before surgery. Mean and median follow up: 36.86 and 13 months . Specific survival rate 100%.Results: We found 24 OR in 10 men and 12 women with a mean age of 59 years (34-84). 12 in the left kidney and 12 in the right one, one patient presenting oncocytomatosis. Tumor mean size was 4.64cm (1-12.5 cm). Tumors were discovered incidentally in 17 cases. Presentation symptoms in the rest of patients were gross hematuria.Conclusions: The rate of OR found in our sample population of renal tumors undergoing surgery matches other se...

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“…In the November 2002 issue of the International Journal of Urology , Shiga et al . reported a case of renal oncocytomatosis in a long‐term hemodialysis patient treated by laparoscopic surgery 1 . The authors concluded that the tumor was oncocytoma because the tumor cells were slightly stained with Hale's colloidal iron 1 .…”

mentioning

confidence: 99%

“…reported a case of renal oncocytomatosis in a long‐term hemodialysis patient treated by laparoscopic surgery 1 . The authors concluded that the tumor was oncocytoma because the tumor cells were slightly stained with Hale's colloidal iron 1 . However, the illustration of the tumor shown in their article corresponds to the eosinophilic variant of chromophobe renal cell carcinoma (RCC) because of the compact structure of the tumor cells, the perinuclear halo and the thick cell border 2 .…”

mentioning

confidence: 99%

“…1 The authors concluded that the tumor was oncocytoma because the tumor cells were slightly stained with Hale's colloidal iron. 1 However, the illustration of the tumor shown in their article corresponds to the eosinophilic variant of chromophobe renal cell carcinoma (RCC) because of the compact structure of the tumor cells, the perinuclear halo and the thick cell border. 2 A recent report suggested that a better result for the detection of chromophobe RCC could be obtained using the modified Mowry's method compared with the Hale's method or the original Mowry's method.…”

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confidence: 99%

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