Renal nephroblastoma in an adult dog

Araujo, Dayane Caicó Collares; Silva, Michel Alves da; Veiga, Cristiano Chaves Pessoa da; Fernandes, Júlio Israel

doi:10.29374/2527-2179.bjvm107820

Cited by 4 publications

(9 citation statements)

References 12 publications

(24 reference statements)

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“…In this case, the mass was sufficiently large to occupy half of the abdominal cavity and was 16.5% of the body weight. In previous studies, RCC did not attain sufficiently massive size to occupy half of the abdominal cavity (10,12,14), however, nephroblastoma could be massive (1,13) × 2, 7 × 5 × 7, 12 × 6, and 8 × 7 × 5 cm) were observed in medium-and large-breed dogs including Collie, Alsatian, Boxer, Afghan, and Labrador (12). Furthermore, in human, RCC with a diameter of >20 cm is extremely rare and can be diagnosed as a huge RCC (4).…”

Section: Discussionmentioning

confidence: 91%

A Rare Case of Canine Huge Renal Cell Carcinoma with Ovarian Metastasis

et al. 2022

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A 10-year-old female Pomeranian weighing 2.25 kg with a history of gradual weight loss and an intraabdominal mass confirmed with ultrasonography at a local hospital was referred to the Veterinary Medical Teaching Hospital, Jeju National University. Physical examination revealed abdominal distention. Blood analysis revealed hypoglycemia (57 mg/dL; reference range, 60-110 mg/dL). On abdominal ultrasonography, a heterogeneously hyperechoic mass measuring 7.51 × 10.6 cm was found at the level of the left kidney. Computed tomographic findings showed a unilateral left kidney mass with a 10-cm diameter and vessel contrast enhancement in the corticomedullary phase. Unilateral nephrectomy and ovariohysterectomy were performed because left ovary enlargement was observed during surgery. The renal mass was adjacent to the aorta and vena cava and attached to a portion of the small intestine, greater omentum, and left ovary. The mass was huge (12.5 × 10 × 7 cm) and was 16.5% of the body weight. Histopathological examination revealed renal cell carcinoma (RCC) and ovarian metastasis. After surgery, clinical signs improved remarkably, and serum glucose level returned to normal. As RCC is resistant to radiation and chemotherapy, the owner decided not to proceed with postoperative adjunctive therapies. To the best of our knowledge, this is the first case report of ovarian metastasis with huge RCC in a dog.

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Section: Discussionmentioning

confidence: 91%

A Rare Case of Canine Huge Renal Cell Carcinoma with Ovarian Metastasis

et al. 2022

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“…A literature review identified 21 case reports and one retrospective study evaluating five reported cases (Table 2). [1][2][3][4][5]7,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] In the literature, variable tumour biological features have been reported. Historically, survival times have been very poor, with the survival time ranging 0-6 months in the 2006 retrospective study.…”

Section: Discussionmentioning

confidence: 99%

“…German shepherd dogs and labrador retrievers are overrepresented for canine spinal cord nephroblastoma 6 . Reported survival times are varied, ranging from 12 days to 33 months 1,7 . In both veterinary and human medicine, nephrectomy, with or without adjuvant chemotherapy, is the treatment of choice for unilateral renal nephroblastoma 3,5,6,8 …”

Section: Introductionmentioning

confidence: 99%

“…6 Reported survival times are varied, ranging from 12 days to 33 months. 1,7 In both veterinary and human medicine, nephrectomy, with or without adjuvant chemotherapy, is the treatment of choice for unilateral renal nephroblastoma. 3,5,6,8 This case report describes a dog presenting with a single abdominal mass that, following complete surgical excision, re-presented 86 days later with massive presumed metastases; providing further evidence of the metastatic potential of this uncommon neoplasm.…”

Section: Introductionmentioning

confidence: 99%

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A case of rapid canine nephroblastoma presumed metastasis documented with advanced imaging

Seddon¹,

Smith²,

Romine³

2023

Vet Record Case Reports

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A 1.5-year-old, female, entire German shepherd dog was presented for evaluation of an abdominal mass. The dog had a 4-month history of polydipsia, polyuria, diarrhoea, and weight loss despite polyphagia. Abdominal ultrasound confirmed a large abdominal mass suspected to be uterine in origin. An exploratory celiotomy revealed a 4.3 kg, 26 × 17 × 17 cm multinodular mass entirely encompassing the uterus, left ovary and left kidney. A combined ovariohysterectomy and left nephrectomy were undertaken. Histopathology confirmed stage ΙΙ renal nephroblastoma with favourable histology. Chemotherapy was declined and 86 days following surgery, significant abdominal metastases were identified on a computed tomography scan. The patient was euthanased 113 days after surgery due to progressive disease. This is the first report to display the rapid presumed metastasis of a canine nephroblastoma, without gross metastasis at initial surgical resection, through advanced imaging. This is also the first reported case of polyphagia despite weight loss as a presenting clinical sign.

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“…Renal nephroblastoma is uncommon in dogs, but reported cases include juvenile and adult dogs, which are treated by nephrectomy with or without adjuvant chemotherapy and have a high metastatic rate (50%) and various survival times (5). Although renal nephroblastoma is most often diagnosed in young dogs (1), case reports of adult animals predominate in the literature (1,5,16,19,25).…”

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confidence: 99%

Holistic management of renal nephroblastoma in a juvenile dog with severe cachexia: A case report

JAŚKIEWICZ¹,

CHOLEWIAK-GÓRALCZYK²,

GRUDZIŃSKI³

et al. 2022

Medycyna Weterynaryjna

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This report presents a case of a 2-month-old female German Shepherd dog with renal nephroblastoma and strong cachexia. The tumour was surgically removed and graded as a stage I with favourable histopathology, but due to its large size, adjuvant chemotherapy, including doxorubicin and vincristine, was recommended. Before, during and after chemotherapy, the body weight was gradually rebuilt with an appropriately balanced diet containing proper amounts of protein, fat and numerous supplements necessary for growth and development. Eighteen months after diagnosis, the dog was in good condition and had no metastases. In conclusion, this case study shows that close cooperation between oncologists and nutritionists is crucial for successful oncological therapy, especially in a cachectic patient.

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Renal nephroblastoma in an adult dog

Abstract: The study was carried out at Hospital Veterinário,

Cited by 4 publications

References 12 publications

A Rare Case of Canine Huge Renal Cell Carcinoma with Ovarian Metastasis

A Rare Case of Canine Huge Renal Cell Carcinoma with Ovarian Metastasis

A case of rapid canine nephroblastoma presumed metastasis documented with advanced imaging

Holistic management of renal nephroblastoma in a juvenile dog with severe cachexia: A case report

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