Renal lesions associated with malignant lymphomas

Richmond, John; Sherman, Robert S.; Diamond, Henry D.; Craver, Lloyd F.

doi:10.1016/0002-9343(62)90289-9

Cited by 362 publications

(152 citation statements)

References 28 publications

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“…CT scan usually reveals a homogeneous mass that shares the density of soft tissues, with a minimal enhancement after injection (Heiken et al, 1983). Incidences of renal involvement subtypes in our patients semed somewhat different from those of previous reports (Richmond et al, 1962;Jafri et al, 1982;Heiken et al, 1983). However, these studies included only a small number of patients and the differences were not signifant.…”

Section: Retscontrasting

confidence: 99%

“…In clinical studies, the prevalence of renal involvement in patients with non-Hodgkin's lymphoma (NHL) ranges from 2.4% to 14% (Richmond et al, 1962;Strauss et al, 1983;Geffen et al, 1985;Richards et al, 1990). This low incidence contrasts with the high prevalence (nearly 50%) of renal involvement found at autopsy (Wentzell & Berkheise, 1955;Martinez-Maldonado & Ramirez de Arellano, 1966;Lalli, 1969;Kandel et al, 1987;Richards et al, 1990).…”

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confidence: 99%

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Aggressive lymphomas with renal involvement: a study of 48 patients treated with the LNH-84 and LNH-87 regimens

Morel

Dupriez²,

Herbrecht³

et al. 1994

Br J Cancer

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S_nmry In order to describe renal involvement in aggressive non-Hodgkin's lymphomas (NHLs) and its prognostic significance, we reviewed the outcome of 48 patients with renal involvement treated with the LNH-84 or LNH-87 regimen. Histology was diffuse large cell in 29 (60%) patients; immmunoblastic, diffuse mixed cell and lymphoblastic in four each; follicular large cell, diffuse small cleaved cell and diffuse small non-cleaved cell in one each; and unclassified in four. Ann Arbor stage was IV in 44 patients, and IE or IIE in four. Tumour mass > 10 cm, performance status (ECOG scale) > 2 and increased LDH level were present in 69%, 20% and 76% of patients respectively. Fifteen patients (31%) had multiple intraparenchymal nodules, 14 (29%) had direct spread into the kidney from a perirenal mass, ten (21%) had a single intraparenchymal nodule and nine (19%) had diffuse infiltration. Twenty-one patients (43%) presented with bilateral lesions. Three patients (6%) presented with acute renal failure. Ten other patients (21%) had serum creatinine >120 zmoll-'. In 12 of these 13 patients renal function was restored with chemotherapy. Twenty-eight patients (57%) achieved complete remission. Estimated 4 year disease-free survival was 39%. Disease-free survival and actuarial survival at 4 years were estimated to be 58% respectively. Two renal parameters had adverse prognostic sig i for survival: renal hilum involvement (P = 0.02) and diffuse renal infiltration (P = 0.01). A Cox model identified only two independent prognostic factors for survival, namely performance status > 2 and tumour size > 10 cm. We conclude that alteration in renal function occurs in 27% of patients with renal involvement. Systemic chemotherapy improves renal function rapidly. Long-term outcome is similar to that expected in NHL patients presenting with the same prognostic factors.

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Section: Retscontrasting

confidence: 99%

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confidence: 99%

Aggressive lymphomas with renal involvement: a study of 48 patients treated with the LNH-84 and LNH-87 regimens

Morel

Dupriez²,

Herbrecht³

et al. 1994

Br J Cancer

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“…Of the 27 patients with lymphoma there were 14 with involvement of either the brain or spinal cord including 10 of the patients with reticulum cell sarcoma, 3 with unclassified lymphoma, and 1 patient with lymphosarcoma. Lymphoreticular tumors within the central nervous system are uncommon (0.04 and 1.5% in two large series) (19,20); yet, in 11 instances in the present study, the brain or spinal cord were the only regions so affected. Probable explanations for the high incidence of central nervous system involvement have been discussed elsewhere (17,21,22).…”

Section: Tumor Types and Organs Affectedcontrasting

confidence: 46%

Malignant Tumors Arising De Novo in Immunosuppressed Organ Transplant Recipients

Penn¹,

Starzl²

1972

Transplantation

290

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SummaryDe novo malignant tumors have been observed throughout the world in 75 chronic survivors of organ transplantation, including 16 of our own patients. The incidence of tumors was approximately 80 times greater than in the average population in a comparable age range. Chronic uremia may have predisposed to the development of some of the tumors, but this has not yet been proved. It seems clear that the predominant etiology was chronic immunosuppression posttransplantation. Forty-four of the patients had epithelial tumors and in 31 the lesions were of mesenchymal origin. On the average the malignancies appeared 29 months after transplantation. Lymphomas showed an unusual predilection for involvement of the central nervous system.

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“…Of the 37 individuals diagnosed with leukemia, 21 (57%) had evidence of leukemic infiltration of the kidneys. Renal leukemic involvement does not usually cause acute renal failure; this occurs in only 1% of children with ALL [11]. Fortunately, our pediatric patient had no evidence of acute renal failure before or after she started therapy.…”

Section: Discussionmentioning

confidence: 64%

Rare Presentation of Pediatric Acute Lymphoblastic Leukemia: Nephromegaly at Time of Diagnosis

Erdem

Kayıran

Özçelik

et al. 2011

Indian J Hematol Blood Transfus

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Renal involvement is a fairly frequent development in children with acute lymphoblastic leukemia, but palpable renal enlargement at time of diagnosis is very unusual. We report the case of a young girl who presented with enlarged kidneys and was diagnosed with this form of leukemia. This case is of interest because of the rarity of this presentation. The importance of renal biopsy in identifying the etiology of this patient's nephromegaly is emphasized.

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Renal lesions associated with malignant lymphomas

Cited by 362 publications

References 28 publications

Aggressive lymphomas with renal involvement: a study of 48 patients treated with the LNH-84 and LNH-87 regimens

Aggressive lymphomas with renal involvement: a study of 48 patients treated with the LNH-84 and LNH-87 regimens

Malignant Tumors Arising De Novo in Immunosuppressed Organ Transplant Recipients

Rare Presentation of Pediatric Acute Lymphoblastic Leukemia: Nephromegaly at Time of Diagnosis

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