Renal Ischemia Reperfusion Causes Brain Hippocampus Oxidative Damage and Inhibition Effect

Fang, Yu; Liang, Haidong; Shi-meng, Xin

doi:10.21010/ajtcam.v13i5.9

Cited by 6 publications

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References 5 publications

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“…Evidences reports that renal I/R increase lipid peroxidation index, MDA level, in the hippocampus tissue of rats. Moreover, the level of antioxidant capacity of the hippocampus tissue decreased after renal IR [47]. Also, AKI promotes the expression of inflammatory mediators that could target the cardiovascular system in particular the myocardium of the heart with directly involvement of immune system [48] .…”

Section: Discussionmentioning

confidence: 99%

Prazosin Treatment Protects Brain and Heart by Diminishing Oxidative Stress and Apoptotic Pathways After Renal Ischemia Reperfusion

et al. 2022

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Acute kidney injury (AKI) is a major medical challenge caused from renal ischemia-reperfusion (IR) injury connected with different cellular events in other distant organs. Renal IR-related oxidative stress and inflammation followed by cell apoptosis play a crucial role in IR-induced distant organ pathological damages. Prazosin has shown protective effects against IR-injuries. Thus, the current study intended to investigate the possible protective role of prazosin against the consequents of renal IR in the heart and brain tissues. To reach this goal, rats were randomly divided into 3 groups (n=7): Sham, IR and prazosin pretreatment-IR animals (1 mg/kg intraperitoneally injection of prazosin 45 min before IR induction). After 6 h reperfusion, lipid peroxidation and antioxidant markers levels were evaluated in the both, brain and heart tissue. Moreover, apoptotic pathway in the heart and brain tissues were assessed by western blotting. Accordingly, prazosin pretreatment in IR model rats could significantly increase the antioxidant capacity and attenuate apoptotic pathways by increasing the bcl-2 levels and decreasing the expression of Bax and caspase 3 enzymes (P<0.05). Thus, prazosin suppressed cellular damages of heart and brain tissues post kidney IR by anti-oxidative and anti-apoptotic effects, which suggests the plausible use of prazosin in improving the clinical outcomes during AKI after further investigations.

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Section: Discussionmentioning

confidence: 99%