Renal involvement in dogs with babesiosis

Lobetti, Remo; Jacobson, Linda S.

doi:10.4102/jsava.v72i1.604

Cited by 57 publications

(69 citation statements)

References 28 publications

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“…This finding differed notably from that observed in dogs infected with other Babesia species. Lobetti and Jacobson [12] studied 30 dogs infected with B. canis and reported that all had well concentrated urine.…”

Section: Discussionmentioning

confidence: 99%

Serum protein response and renal failure in canine Babesia annae infection

Camacho¹,

Guitian

Pallas

et al. 2005

Vet. Res.

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-Babesia annae piroplasms have recently been recognised as a cause of infection and disease among dogs in Europe. The pathogenesis and clinical implications of this emerging disease remain poorly understood. We conducted this study to describe the electrophoretic profiles associated with the infection and to determine if B. annae associated azotaemia is caused by renal failure. We examined by microscopy 2 979 canine blood samples submitted to a diagnostic laboratory in NW Spain between September 2001 and April 2002. Small ring-shaped piroplasms were detected in blood smears of 87 samples and the identity of 58 of these presumptive cases were confirmed by PCR. This group of 58 infected dogs and a reference group of 15 healthy non-infected dogs were our study population. For all the dogs, serum protein response to -albumin, alpha-1 globulin, alpha-2 globulin, beta globulin and gamma globulin-was measured by capillary electrophoresis. The response of infected and non-infected dogs was compared and within infected dogs, the response of those with azotaemia (19) was compared with that of non-azotaemic dogs (39). Infected dogs presented a significant elevation of total proteins and all the different globulin fractions, and significantly lower levels of albumin compared to non-infected dogs. Among infected dogs, those presenting azotaemia had significantly lower concentrations of total proteins, albumin, beta and gamma globulins, and significantly higher values of alpha-2 globulin. Specific gravity was below the threshold of 1 025 for all dogs with azotaemia for which a urine sample was available (7) suggesting that azotaemia, in these dogs was of renal origin. Azotaemic dogs had higher concentrations of cholesterol and triglycerides, probably as a result of a liver compensatory response to the loss of proteins. We conclude that serum protein response in B. annae infected dogs corresponds to the pattern of a haemolytic syndrome with intense inflammatory reaction and that the azotaemia associated to the infection is very likely of renal origin. serum proteins / Babesia annae / azotaemia / renal failure

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Section: Discussionmentioning

confidence: 99%

Serum protein response and renal failure in canine Babesia annae infection

Camacho¹,

Guitian

Pallas

et al. 2005

Vet. Res.

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“…Granular casts and RTE cells, possibly indicative of renal tubular injury (Lobetti and Jacobson, 2001), were only present in the urine of a minority of dogs in group B. Based on the pathogenesis of babesiosis, the observed proteinuria could be either of prerenal (hemoglobinemia, myoglobinemia) or renal origin (Lees et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…These concentrations were based on previously published urinary hemoglobin concentrations in dogs with babesiosis Lobetti and Jacobson, 2001). …”

Section: Hemoglobin Interference Testingmentioning

confidence: 99%

“…There is enough evidence to suggest that renal dysfunction is a serious complication associated with canine babesiosis that has been shown to influence outcome (Lobetti and Jacobson, 2001;Welzl et al, 2001). Therefore, sensitive markers are necessary for the early diagnosis of renal dysfunction in canine babesiosis.…”

mentioning

confidence: 99%

“…However, pre-renal azotemia could not be excluded in some of these cases (Garcia, 2006). Minimal renal damage is identified more often than overt acute renal failure, making 'renal involvement' a more suitable description for this complication (Lobetti and Jacobson, 2001). …”

mentioning

confidence: 99%

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Assessment of renal dysfunction using urinary markers in canine babesiosis caused by Babesia rossi

Defauw

Schoeman

Smets

et al. 2012

Veterinary Parasitology

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Renal damage is deemed a common, yet poorly documented, complication in canine babesiosis.Serum urea and creatinine are insensitive and non-specific markers of early renal dysfunction and 2 their measurements are influenced by hemolysis caused by babesiosis. Therefore, the aim of this study was to use urinary markers to assess the localization and degree of renal dysfunction in dogs with Babesia rossi infection. Urinary immunoglobulin G (uIgG) and urinary C-reactive protein (uCRP) were measured as markers for glomerular dysfunction, while urinary retinol-binding protein (uRBP) was used as a marker for tubular dysfunction. Eighteen dogs presenting with uncomplicated babesiosis were included and compared with eight clinically healthy dogs. Previously validated commercial ELISA kits were used for the measurement of uIgG, uCRP, and uRBP. Results were related to urinary creatinine concentrations (c). Dogs with babesiosis had significantly higher concentrations of all three measured urinary markers compared to healthy dogs. Except for urinary protein/c ratio (UPC), routine urinary and serum markers for renal function (urine specific gravity (USG), serum urea and creatinine (sCr)) were not significantly different between dogs with babesiosis and healthy dogs.All three urinary markers were positively correlated with each other and with UPC. The data supports the presence of both glomerular and tubular dysfunction in dogs suffering from uncomplicated B. rossi infection. Urinary markers were superior to USG, serum urea and creatinine concentrations for the early detection of renal dysfunction in dogs with babesiosis.

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Prognostic markers and their discriminant score in predicting the outcome of Babesia gibsoni infection

et al. 2021

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Background: We aimed to identify prognostic markers and their discriminant score in predicting the lethal outcome of canine Babesia gibsoni. Methods: Blood samples were collected from 108 client‐owned dogs with clinical signs commensurate with babesiosis to analyze haematological, biochemical, haemostatic, antioxidant profile and thiobarbituric acid reactive substance levels. Samples were screened for Babesia infection (microscopic and molecular techniques). Babesiosis‐affected dogs were classified into survivors and non‐survivors, and 30 healthy dogs were used in the control group. Results: Haemoglobin, thrombocytes, catalase, urea, creatinine, alanine aminotransferase (ALT), alkaline phosphatase, lactate and reticulocytes were highly correlated to survival. Receiver operating characteristics analysis revealed urea, ALT and lactate as specific prognostic markers for the disease. The formula for calculation of discriminant scores (Di) for lethal outcome of the disease was generated with cut‐off score 0.141. The scoring system was 79% sensitive and 83% specific in predicting the lethal outcome of the disease. Conclusions: A scoring system developed from the prognosticating markers may aid in predicting the outcome of Babesia gibsoni infection on the day of presentation itself enabling intensive care for those animals with a cut‐off score more than 0.141.

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Renal involvement in dogs with babesiosis

Cited by 57 publications

References 28 publications

Serum protein response and renal failure in canine Babesia annae infection

Serum protein response and renal failure in canine Babesia annae infection

Assessment of renal dysfunction using urinary markers in canine babesiosis caused by Babesia rossi

Prognostic markers and their discriminant score in predicting the outcome of Babesia gibsoni infection

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