2019
DOI: 10.1177/1040638719897585
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Renal interstitial cell tumor in a dog: clinicopathologic, imaging, and histologic features

Abstract: Renal interstitial cell tumors are benign tumors of renomedullary origin; however, malignant features have not been reported in dogs, to our knowledge. A 17-y-old spayed female Maltese dog was presented to a local animal hospital with a mass in the right abdomen. Clinicopathologic findings prior to surgery revealed renal insufficiency and anemia. Imaging revealed that the right kidney was enlarged by an amorphous mass with opaque areas, indicative of mineralization. Upon histologic examination, the mass was co… Show more

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Cited by 2 publications
(19 citation statements)
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“…A diagnosis of RICT was achieved based on the morphologic and IHC features of the mesenchymal neoplasm in the kidney, myocardium, and brain. 5,6,8 Similar to descriptions of RICTs in dogs, tumors were bilateral and multiple. 6 Histologically, RICTs need to be distinguished from renal fibromas and other renal sarcomas.…”
supporting
confidence: 60%
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“…A diagnosis of RICT was achieved based on the morphologic and IHC features of the mesenchymal neoplasm in the kidney, myocardium, and brain. 5,6,8 Similar to descriptions of RICTs in dogs, tumors were bilateral and multiple. 6 Histologically, RICTs need to be distinguished from renal fibromas and other renal sarcomas.…”
supporting
confidence: 60%
“…Second, the presence of an extracellular AB-positive myxomatous matrix is a typical feature described in RICTs but not in renal fibromas. 5 Third, cytoplasmic immunolabeling for both vimentin and COX-2 is highly supportive of a diagnosis of RICT and a useful finding to rule out a fibrosarcoma (which should be negative for COX-2), as described in RICTs in dogs and humans. 5,8 A vascular neoplasm was ruled out based on the lack of immunolabeling for factor 8–related antigen.…”
mentioning
confidence: 85%
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