Renal impairment and time to fracture healing following surgical fixation of distal radius fracture

Lai, Aiping; Tang, Camelia Qian Ying; Chiow, Si Min; Chia, Dawn Sinn Yii

doi:10.1007/s00590-022-03300-4

Cited by 1 publication

(1 citation statement)

References 40 publications

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“…The complex interplay of MSCs with local macrophages, osteoprogenitor cells, osteoblasts, osteoclasts, and chondrocytes is crucial to ensure a regular healing process (Figure 2). Numerous conditions including smoking and disease-specific peculiarities have been found to impair this well-balanced process [28][29][30][31]. In order to reveal the cellular basis of impairment in non-unions, individual cell types are here illustrated separately before focusing on the microenvironment.…”

Section: Cellular Components Contributing To (Impaired) Bone Healingmentioning

confidence: 99%

Bone Healing Gone Wrong: Pathological Fracture Healing and Non-Unions—Overview of Basic and Clinical Aspects and Systematic Review of Risk Factors

et al. 2023

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Bone healing is a multifarious process involving mesenchymal stem cells, osteoprogenitor cells, macrophages, osteoblasts and -clasts, and chondrocytes to restore the osseous tissue. Particularly in long bones including the tibia, clavicle, humerus and femur, this process fails in 2–10% of all fractures, with devastating effects for the patient and the healthcare system. Underlying reasons for this failure are manifold, from lack of biomechanical stability to impaired biological host conditions and wound-immanent intricacies. In this review, we describe the cellular components involved in impaired bone healing and how they interfere with the delicately orchestrated processes of bone repair and formation. We subsequently outline and weigh the risk factors for the development of non-unions that have been established in the literature. Therapeutic prospects are illustrated and put into clinical perspective, before the applicability of biomarkers is finally discussed.

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Section: Cellular Components Contributing To (Impaired) Bone Healingmentioning

confidence: 99%

Bone Healing Gone Wrong: Pathological Fracture Healing and Non-Unions—Overview of Basic and Clinical Aspects and Systematic Review of Risk Factors

et al. 2023

View full text Add to dashboard Cite

show abstract

Renal impairment and time to fracture healing following surgical fixation of distal radius fracture

Cited by 1 publication

References 40 publications

Bone Healing Gone Wrong: Pathological Fracture Healing and Non-Unions—Overview of Basic and Clinical Aspects and Systematic Review of Risk Factors

Bone Healing Gone Wrong: Pathological Fracture Healing and Non-Unions—Overview of Basic and Clinical Aspects and Systematic Review of Risk Factors

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