Introduction: Infertility is mediated by several changes system-wide. These changes are likely to cause other systems-related pathologies, such as changes in systemic immune response, particularly inflammatory response can lead to cardiovascular diseases and breast cancer. Methods: These morbidities can exist immediately or years after the diagnosis of infertility. Therefore, understanding the mechanism is important to move toward therapeutic interventions. Results: Several extragonadal pathologies are reported due to infertility, as well as, how these might also contribute to reproductive disabilities. Detailed evidence are still not present that can give stronger result. Conclusion: This review highlights some of the most frequent comorbidities that are seen in infertile women, hence requiring a need for complete clinical screening and care, as well as diagnosis and treatment in early stages. K E Y W O R D S extragonadal comorbidities, infertile women, infertility 1 | INTRODUCTION Up to 18% of general population is prone to infertility. 1 However, fewer studies target coexisting pathologies with infertility. Infertility is not a remote pathology and it can proffer effects on various systems in the body. Women infertility can have several causes, such as polycystic ovary syndrome (PCOS), endometriosis, tubal blockage, and hydrosalpinges. 2-4 Despite, availability of diversity of treatment options, prevalence extragonadal pathologies might influence the treatment outcomes for infertility. 5,6 Certain dietary intake can also elevate the risk to attain infertility. 7 A study reports genital infections like those in vagina, uterus, and ovaries that greatly contributes to infertility rather than cardiovascular factors. 8 PCOS is characterized by various phenotypes (Figure 1) and thereby existence of comorbidities varies according to each category. In general, these women present elevated body mass index (BMI), follicle count