Renal Hemodynamics in Human Subjects and in Animals with Genetic Hypertension during the Prehypertensive Stage

Bianchi, Giuseppe; Cusi, Daniele; Guidi, Ettore

doi:10.1159/000166695

Cited by 18 publications

(6 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…If the linkage between sodium sensitivity of BP and glomerular hypertension is as proposed, renal failure may be expected to be more common in sodium-sensitive types of hypertension than in non-sodium-sensitive types. Indeed, animal models characterized by increased sodium sensitivity of BP are proved to show glomerular hypertension and more profound renal injury [5, 58, 59, 62, 90, 91, 92, 93, 94, 95, 96]. …”

Section: Renal Mechanisms Of Sodium Sensitivitymentioning

confidence: 99%

Sodium Sensitivity of Blood Pressure: A New Prognostic Factor in Hypertension

Kimura

1999

Nephron

View full text Add to dashboard Cite

Section: Renal Mechanisms Of Sodium Sensitivitymentioning

confidence: 99%

Sodium Sensitivity of Blood Pressure: A New Prognostic Factor in Hypertension

Kimura

1999

Nephron

View full text Add to dashboard Cite

“…262 A more accelerated course of renal disease was also observed in other experimental models of salt-sensitive hypertension, such as the deoxycorticosterone acetate-salt hypertensive rat, 263 the uninephrectomized SHR, 264 the Holtzman postsalt model of hypertension, 265 and the Milan strain of SHR. 266 All these salt-sensitive models of hypertension manifest a decrease in afferent arteriolar resistance and rise in glomerular pressure in response to an increase in blood pressure.…”

mentioning

confidence: 99%

Salt sensitivity in hypertension. Renal and cardiovascular implications.

1994

View full text Add to dashboard Cite

The mechanisms responsible for the increase in blood pressure response to high salt intake in salt-sensitive patients with essential hypertension are complex and only partially understood. A complex interaction between neuroendocrine factors and the kidney may underlie the propensity for such patients to retain salt and develop salt-dependent hypertension. The possible role of vasodilator and natriuretic agents, such as the prostaglandins, endothelium-derived relaxing factor, atrial natriuretic factor, and kinin-kallikrein system, requires further investigation. An association between salt sensitivity and a greater propensity to develop renal failure has been described in certain groups of hypertensive patients, such as blacks, the elderly, and those with diabetes mellitus. Salt-sensitive patients with essential hypertension manifest a deranged renal hemodynamic adaptation to a high dietary salt intake. During a low salt diet, salt-sensitive and salt-resistant patients have similar mean arterial pressure, glomerular filtra-D espite extensive research, controversy still exists regarding the role of dietary salt (NaCI) in hypertension.

show abstract

“…43 All of these salt-sensitive models of hypertension manifest a decrease in afferent arteriolar resistance and a rise in glomerular pressure in response to an increase in blood pressure.…”

mentioning

confidence: 99%

Microalbuminuria in salt-sensitive patients. A marker for renal and cardiovascular risk factors.

Bigazzi¹,

Bianchi²,

Baldari³

et al. 1994

Hypertension

236

138

View full text Add to dashboard Cite

We previously showed that a high salt diet increases glomerular capillary pressure in salt-sensitive hypertensive patients and suggested that this may underlie the greater propensity of these patients to develop renal failure. Because microalbuminuria is considered an initial sign of renal damage, we have tested whether salt-sensitive patients display greater urinary albumin excretion than salt-resistant hypertensive patients. Twenty-two patients were placed on a low sodium intake (20 mEq/d) for 7 days followed by a high sodium diet (250 mEq/d) for 7 more days. Twelve patients were classified as salt sensitive and 10 as salt resistant. Urinary albumin excretion was greater in salt-sensitive than saltresistant patients (54±11 versus 22±5 mg/24 h, P<.01). During the low sodium diet, glomerular filtration rate, renal plasma flow, and filtration fraction were similar between the two groups. During the high sodium intake, glomerular filtration, renal plasma flow, filtration fraction, and calculated intraglomerular pressure did not change in salt-resistant patients; in salt-sensitive patients, however, renal plasma flow decreased, and filtration fraction and intraglomerular pressure increased, whereas glomerular filtration rate did not change. Urinary albumin excretion was significantly correlated with glomerular capillary pressure. Salt-sensitive patients displayed higher serum levels of low-density lipoprotein cholesterol and lipoprotein(a) and lower levels of high-density lipoprotein cholesterol than salt-resistant patients. These studies have shown greater urinary albumin excretion and serum concentrations of atherogenic lipoproteins in salt-sensitive than in salt-resistant hypertensive patients, suggesting that salt sensitivity may be a marker for greater risk of renal and cardiovascular complications. (Hypertension. 1994;23:195-199.)

show abstract

Renal Hemodynamics in Human Subjects and in Animals with Genetic Hypertension during the Prehypertensive Stage

Cited by 18 publications

References 34 publications

Sodium Sensitivity of Blood Pressure: A New Prognostic Factor in Hypertension

Sodium Sensitivity of Blood Pressure: A New Prognostic Factor in Hypertension

Salt sensitivity in hypertension. Renal and cardiovascular implications.

Microalbuminuria in salt-sensitive patients. A marker for renal and cardiovascular risk factors.

Contact Info

Product

Resources

About