Sodium Sensitivity of Blood Pressure: A New Prognostic Factor in Hypertension

Kimura, Genjiro

doi:10.1159/000045484

Cited by 11 publications

(7 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We propose that this non-dipper circadian BP rhythm would give rise to cardiovascular events as a function of renal functional loss (60). This hypothesis is consistent with reports that the non-dipper pattern was observed in patients with sodium-sensitive hypertension (36,38,44), who are at high risk for cardiovascular events (61)(62)(63).…”

Section: As the Condition Progresses To Mild Essential Hypertension (supporting

confidence: 90%

“…These are based on perspectives such as organ protection, a metabolic viewpoint that neither new onset of diabetes mellitus nor atherosclerosis is promoted and the need to avoid certain drugs, depending on the underlying disease or organ damage. We previously reported that the sodium sensitivity of BP occurring with diminished renal functional reserve reflects a predisposition to cardiovascular complications (61,62). Diabetes mellitus and nephropathy increase sodium sensitivity.…”

Section: Perspectivesmentioning

confidence: 99%

See 1 more Smart Citation

Pathophysiology of Antihypertensive Therapy with Diuretics

Fukuda

Kimura

2006

Hypertens Res

Self Cite

View full text Add to dashboard Cite

Section: As the Condition Progresses To Mild Essential Hypertension (supporting

confidence: 90%

Section: Perspectivesmentioning

confidence: 99%

Pathophysiology of Antihypertensive Therapy with Diuretics

Fukuda

Kimura

2006

Hypertens Res

Self Cite

View full text Add to dashboard Cite

“…20,21 A total of 156 patients with essential hypertension were placed on a high-salt (12-15 g NaCl per day) diet and on a low-salt (1-3 g per day) diet for 1 week each in randomized order to determine salt sensitivity. 20,[22][23][24][25] Patients were then followed up for 7.3±4.3 years until the occurrence of end points such as ischemic heart disease or stroke.…”

Section: Salt Sensitivity and Cardiovascular Eventsmentioning

confidence: 99%

“…Therefore, in the salt-sensitive state, several risk factors are clustered together, leading to future cardiovascular events and renal failure. 20,21,26,[82][83][84][85][86] In our follow-up study 20 of essential hypertensive patients with known salt sensitivity, 31 cardiovascular events were documented during the follow-up period. Of these, 21 were stroke.…”

Section: Salt Sensitivity and Strokementioning

confidence: 99%

Salt sensitivity and circadian rhythm of blood pressure: the keys to connect CKD with cardiovasucular events

2010

Self Cite

View full text Add to dashboard Cite

In healthy subjects, blood pressure (BP) drops by 10-20% during the night. Conversely, in patients with the salt-sensitive type of hypertension or chronic kidney disease, nighttime BP does not fall, resulting in an atypical pattern of circadian BP rhythm that does not dip. This pattern is referred to as the 'non-dipper' pattern. Loss of renal functional reserve, due to either reduced ultrafiltration capacity or enhanced tubular sodium reabsorption, induces the salt-sensitive type of hypertension. When salt intake is excessive in patients with salt-sensitive hypertension, the defect in sodium excretory capability becomes evident, resulting in elevated BP during the night. This nocturnal hypertension compensates for diminished natriuresis during the daytime and enhances pressure natriuresis during the night. Nocturnal hypertension and the non-dipper pattern of circadian BP rhythm cause cardiovascular events. When excess salt intake is loaded in patients who are in a salt-sensitive state, glomerular capillary pressure is also elevated, resulting in glomerular sclerosis and eventual renal failure. In this way, salt sensitivity and excess salt intake contribute to both cardiovascular and renal damage at the same time. We propose that salt sensitivity of BP and excess salt intake have important roles in the genesis of the cardiorenal connection. Salt sensitivity and circadian rhythm of BP are the keys to understanding the connections between cardiovascular and renal complications.

show abstract

“…A relação direta entre ingestão de sal e pressão arterial é bem estabelecida em estudos epidemiológicos e experimentais [20][21][22] . No passado, a restrição de sal era recomendada para mulheres com hipertensão arterial na gestação.…”

Section: Introductionunclassified

"Consumo de sal durante a gestação e lactação em ratas Wistar : efeitos sobre a pressão arterial, sensibilidade à insulina e perfil lipídico na prole adulta"

Júnior¹,

Ferreira²

View full text Add to dashboard Cite

Sodium Sensitivity of Blood Pressure: A New Prognostic Factor in Hypertension

Cited by 11 publications

References 87 publications

Pathophysiology of Antihypertensive Therapy with Diuretics

Pathophysiology of Antihypertensive Therapy with Diuretics

Salt sensitivity and circadian rhythm of blood pressure: the keys to connect CKD with cardiovasucular events

"Consumo de sal durante a gestação e lactação em ratas Wistar : efeitos sobre a pressão arterial, sensibilidade à insulina e perfil lipídico na prole adulta"

Contact Info

Product

Resources

About