Renal hemodynamics in heart disease

Heller, B.I.; Jacobson, W.E.

doi:10.1016/0002-8703(50)90216-x

Cited by 76 publications

(6 citation statements)

References 13 publications

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“…These findings are similar to those reported by Blegen and Aas (1950), Heller andJacobson (1950), andWerko et al (1952), and in many of the cases confirm that changes in renal circulation in patients with valvular heart disease occur long before the onset of congestive heart failure. After operation the renal blood flow and renal plasma flow often increased, but did not return to the normal range in any of the patients, and only in Case 12 did the glomerular filtration rate reach normal levels.…”

Section: Discussionsupporting

confidence: 91%

Effect of Mitral Valvotomy on Renal Function

Hammond¹,

Mackinnon²,

Whitaker³

1956

BMJ

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Section: Discussionsupporting

confidence: 91%

Effect of Mitral Valvotomy on Renal Function

Hammond¹,

Mackinnon²,

Whitaker³

1956

BMJ

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“…The renal clearance studies were repeated during the administration of adrenaline. Renal plasma flow was determined by the clearance of para-aminohippurate as previously described (5). The glomerular filtration rate was measured by the clearance of inulin utilizing the method of Roe, Epstein, and Goldstein (6).…”

Section: Methodsmentioning

confidence: 99%

The Effects of Adrenaline Upon Renal Function and Electrolyte Excretion 1

Jacobson¹,

Hammarsten²,

Heller³

1951

J. Clin. Invest.

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The subcutaneous and intravenous infusion of adrenaline in man at a rate of 8 to 10 gamma per minute has previously been shown to produce a decrease in both renal plasma flow and glomerular filtration rate (1-4). The changes are not, however, proportional; and thus with a greater reduction in the plasma flow, a rise in filtration fraction results. The effects of the adrenaline-induced renal ischemia and hypofiltration on electrolyte excretion have not been adequately described. It is the purpose of this report to present data concerning the effect of intravenous adrenaline on both renal function and electrolyte excretion. METHODSStudies of renal function and determinations of electrolyte excretion were conducted on 12 young men without evidence of cardiovascular or renal disease. The experimental subjects received a normal hospital diet which contained between 7 and 15 grams of sodium chloride daily. The experiments were performed with the patients in the basal state after adequate hydration by the oral ingestion of one liter of water 60 to 90 minutes before the study. After three control periods of 15 minutes each, 0.45 to 0.80 mg. of adrenaline was administered by a constant injection syringe during a 45 minute period. The renal clearance studies were repeated during the administration of adrenaline. Renal plasma flow was determined by the clearance of para-aminohippurate as previously described (5). The glomerular filtration rate was measured by the clearance of inulin utilizing the method of Roe, Epstein, and Goldstein (6). The average priming solution of sodium para-aminohippurate and inulin consisted of 3 cc. and 50 cc., respectively. The average sustaining solution contained 14 cc. of sodium para-aminohippurate and 100 cc. of inulin, diluted to 200 cc. with triple distilled water. Approximately 150 cc. of sustaining solution was used for each experiment.Sodium and potassium were determined by an internal standard Perkin-Elmer flame photometer. Chloride was 1 Published with the approval of the Chief Medical Director. The statements and conclusions published by the authors are the result of their own study and do not necessarily reflect the opinion or policy of the Veterans Administration.determined by the titrimetric iodate method of Sendroy as modified by Van Slyke and Hiller (7). RESULTSThe control values for renal hemodynamic and electrolyte studies are the averages of three consecutive periods. The values during the constant infusion of adrenaline are the averages of two periods beginning 15 minutes after the start of the infusion.There was a marked and significant decrease in the mean renal plasma flow (t = 7.82, P < 0.01). In nine subjects the rate of glomerular filtration decreased, and in the other three it increased slightly. The mean change in the filtration rate was statistically significant (t = 2.62, P < 0.02). The filtration fraction increased in all patients, and the mean change was highly significant (t = 9.32, P < 0.01). The clearance data are recorded in Table I.The serum sodium and chlor...

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“…The etiology of the altered fluid balance in CHF can be attributed to both hemodynamic (1,3,5,7) and hormonal factors (4,(8)(9)(10)(11). Evidence has been presented by several investigators that the secretion of antidiuretic hormone (ADH) may be altered during CHF or related disease states (12)(13)(14)(15)(16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%