Renal handling of acute sodium loads in pregnancy

Katz, A I; Lindheimer,

doi:10.1152/ajplegacy.1973.225.3.696

Cited by 19 publications

(17 citation statements)

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“…Katz & Lindheimer (1973) and Davison & Lindheimer (1980), however, were unable to demonstrate such results in early pregnancy but suggested that the difference might be explained by their use of conscious animals.…”

Section: Sodiummentioning

confidence: 94%

“…For the pregnant rat, some similarities with human pregnancy have been demonstrated at a whole kidney level in that g.f.r. is increased (Matthews & Taylor, 1959;Lindheimer & Katz, 1971;Atherton & Pirie, 1977) and there is increased salt and water reabsorption (Lichton, 1963;Lichton & Hugh, 1968;Katz & Lindheimer, 1973;Atherton & Pirie, 1977). While it has been demonstrated that rats normally have some glucose in the urine (see Bishop, Elegbe, Green & Thomas, 1978, for references), it is not known whether pregnancy influences the amount that is excreted.…”

Section: Introductionmentioning

confidence: 99%

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Effects of pregnancy on glucose handling by rat kidneys.

Bishop¹,

Green²

1980

The Journal of Physiology

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SUMMARY1. Glomerular filtration rate (g.f.r.), and renal reabsorption and excretion of glucose, sodium and potassium were measured in 7-8 day pregnant rats and agematched (12-13 week old) virgin controls undergoing saline and glucose infusions.2. Pregnancy was associated with an increased g.f.r. and a decreased urine flow rate during both infusions.3. During saline infusion, more glucose was excreted in pregnant animals than in virgins but with no significant difference in fractional reabsorption. During glucose infusion, pregnant animals excreted less glucose than virgins, owing to a decrease in the filtered load but with no significant difference in fractional reabsorption.4. During both saline and glucose infusion, pregnant animals excreted less sodium than virgin controls.5. During saline infusion, pregnant animals excreted more potassium. During glucose infusion, pregnant animals excreted less potassium than control animals.

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Section: Sodiummentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Effects of pregnancy on glucose handling by rat kidneys.

Bishop¹,

Green²

1980

The Journal of Physiology

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“…The elevated GFR in creases the filtered load of all constituents including sodium. Coupled with this, there is evidence for an enhanced reabsorption of sodium and water close to term [13,[16][17][18][19][20]22], although contradicting reports also exist [6,15].…”

Section: Introductionmentioning

confidence: 95%

Changes in Body Weight, Kidney Weight and Proximal Tubule Length during Pregnancy in the Rat

Garland

Green

Moriarty³

1978

Kidney Blood Press Res

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Pregnant rats became significantly heavier than non-pregnant controls 2 days after conception. Just prior to term, they exhibited a gross 52% increase over their non-pregnant body weight. Dry kidney weight had increased by 13% in 7-day-pregnant animals, which also showed a 20% increase in proximal renal tubule lengths. At term, the former was not maintained as compared with controls; whereas the latter is maintained throughout pregnancy, and may, at least partially, account for the enhanced renal reabsorption of salt and water found in these animals.

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“…These have been documented best in humans (see Hytten & Leitch, 1971) but qualitatively similar changes have been described in rats with respect to alterations in glomerular filtration rate (G.F.R.) (Matthews & Taylor, 1959; Lindheimer & Katz, 1971;Atherton & Pirie, 1977;Bishop & Green, 1980), increased salt and water reabsorption (Lichton, 1963;Lichton & Hugh, 1968;Katz & Lindheimer, 1973;Atherton & Pirie, 1977;Bishop & Green, 1980) and increased amounts of glucose in the urine (Bishop & Green, 1980 an increased filtered load of glucose overloading the normal reabsorptive capacity of the proximal tubule (Christiansen, 1958) or to a decreased reabsorptive capacity of the proximal tubule (Welsh & Sims, 1960). Neither of these hypotheses has been tested by direct micropuncture analysis of proximal tubular function.…”

Section: Introductionmentioning

confidence: 64%

“…Although increased sodium and water reabsorption have been described during saline (Lichton, 1963;Lichton & Hugh, 1968;Katz & Lindheimer, 1973;Atherton & Pirie, 1977;Bishop & Green, 1980) and glucose infusion (Bishop & Green, 1980) during pregnancy in the rat, the stage of pregnancy at which these increases become apparent differs in different experimental series. Davison & Lindheimer (1980) were unable to find an increase in 9-to 10-day pregnant rats, and attributed this to using conscious instead of anaesthetized animals; but Atherton (1981) has presented evidence to the contrary and showed that the increased sodium and fluid reabsorption were greater in conscious animals when compared with anaesthetized at this stage.…”

Section: Sodium and Fluidmentioning

confidence: 99%

Effects of pregnancy on glucose reabsorption by the proximal convoluted tubule in the rat.

Bishop¹,

Green²

1981

The Journal of Physiology

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SUMMARY1. Free-flow micropuncture techniques were used to investigate glucose, sodium and water reabsorption along the proximal convoluted tubule in 7-8 day pregnant rats undergoing saline or glucose infusion and in virgin controls.2. Absolute proximal tubular reabsorption of glucose was greater in pregnant animals than virgins during both saline and glucose infusion; and fractional reabsorption of glucose was higher in pregnant than in virgin animals during glucose infusion.3. During glucose loading, less glucose escaped reabsorption in the proximal tubule in pregnant than in virgin animals. It is concluded that the increased excretion of glucose observed in pregnant rats cannot be due to failure of proximal tubular mechanisms.4. During saline infusion pregnant animals had a higher single nephron glomerular filtration rate (s.N.G.F.R.) when compared with virgin animals and a corresponding increase in reabsorption of sodium and water. The small increases in S.N.G.F.R. and sodium reabsorption in pregnant animals (compared with virgin animals) during glucose infusion were not statistically significant.5. Fractional reabsorption of sodium (and water) along the proximal convoluted tubule was not significantly different in the four series. It is concluded that glomerulo-tubular balance operates during pregnancy.

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Renal handling of acute sodium loads in pregnancy

Cited by 19 publications

References 0 publications

Effects of pregnancy on glucose handling by rat kidneys.

Effects of pregnancy on glucose handling by rat kidneys.

Changes in Body Weight, Kidney Weight and Proximal Tubule Length during Pregnancy in the Rat

Effects of pregnancy on glucose reabsorption by the proximal convoluted tubule in the rat.

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