Renal handling of 3?-5?-cyclic AMP in the rat

Butlen, Daniel; Jard, Serge

doi:10.1007/bf00587260

Cited by 69 publications

(12 citation statements)

References 36 publications

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“…In five patients with nonparathyroid hypercalcemia, NcAMP averaged 0.26 nmol/100 ml GF (range: nondetectable to 0.40 nmol/100 ml GF), and plasma iPTH averaged 31 ,uleq/ml (range: nondetectable to 56 /Aleq/ml). In three patients with apparent "ectopic hyperparathyroidism", NcAMP averaged 4.57 nmol/ 100 ml GF (range: 3.97 to 5.32 nmol/100 ml GF), and plasma iPTH averaged 51 ,uleq/ml (range: 49 to 52 ,uleq/ml).…”

Section: Discussionmentioning

confidence: 91%

“…Although the state of hydration (13,29,31,32) or the consumption of methyl xanthines (29,37) do not appear to influence cAMP excretion, physical activity has been reported to increase plasma cAMP (25) Both plasma iPTH (3,38,39) and plasma and urinary cAMP (18,29,37) have been reported to exhibit a diurnal variation, although in each case there is disagreement as to the exact pattern and extent of variation. In 52 patients, plasma cAMP was determined between 8 and 9 a.m. and again between 11 a.m. and 12 noon.…”

Section: Study Protocolmentioning

confidence: 99%

“…Nephrogenous cAMP (NcAMP): (a) is the only "pool" ofthe nucleotide easily quantified in vivo (28), (b) reflects almost exclusively the effects of circulating PTH (9,29), and (c) appears to be added directly to the tubular urine (9,10), thus accounting for the magnitude, rapidity, and sensitivity of the PTH-induced changes in cAMP excretion. Although vasopressin also acts directly on a renal adenylate cyclase system (8,30), at physiologic concentrations it has little, if any, effect on cAMP excretion (13,29,31,32). Thus, the determination of NcAMP should provide a sensitive and specific assessment of parathyroid function, and several recent reports suggest that this measurement is extremely useful in the diagnosis of 10 HPT (33)(34)(35) Patients with hypoparathyroidism.…”

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confidence: 99%

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Nephrogenous Cyclic Adenosine Monophosphate as a Parathyroid Function Test

Broadus¹,

Mahaffey²,

Bartter³

et al. 1977

J. Clin. Invest.

295

112

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A B S T R A C T Nephrogenous cyclic AMP (NcAMP), total cyclic AMP excretion (UcAMP), and plasma immunoreactive parathyroid hormone (iPTH), determined with a multivalent antiserum, were prospectively measured in 55 control subjects, 57 patients with primary hyperparathyroidism (10 HPT), and 10 patients with chronic hypoparathyroidism.In the group with 1°HPT, NcAMP was elevated in 52 patients (91%), and similar elevations were noted in subgroups of 26 patients with mild (serum calcium c 10.7 mg/dl) or intermittent hypercalcemia, 19 patients with mild renal insufficiency (mean glomerular filtration rate, 64 mllmin), and 10 patients with moderate renal insufficiency (mean glomerular filtration rate, 43 ml/min). Plasma iPTH was increased in 41 patients (73%).The development of a parametric expression for UcAMP was found to be critically important in the clinical interpretation of results for total cAMP excretion. Because of renal impairment in a large number of patients, the absolute excretion rate of cAMP correlated poorly with the hyperparathyroid state. Expressed as a function of creatinine excretion, UcAMP was elevated in 81% of patients with 10 HPT, but the nonparametric nature of the expression led to a number of interpretive difficulties. The expression of cAMP excretion as a function of glomerular filtration rate was developed on the basis of the unique features of cAMP clearance in man, and this expression, which provided elevated values in 51 (89%) ofthe patients with 10 HPT, avoided entirely the inadequacies of alternative expressions.Results for NcAMP and UcAMP in nonazotemic and azotemic patients with hypoparathyroidism confirmed An abstract ofthis work appeared in 1976. Clin. Res. 24: 456A.

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Section: Discussionmentioning

confidence: 91%

Section: Study Protocolmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Nephrogenous Cyclic Adenosine Monophosphate as a Parathyroid Function Test

Broadus¹,

Mahaffey²,

Bartter³

et al. 1977

J. Clin. Invest.

295

112

View full text Add to dashboard Cite

show abstract

“…Some investigators doubt it (Butlen and Jard 1972;Agus et al 1973;Kuntziger et al 1974;Dziak and Stern 1975), but others have shown that cyclic AMP or its dibutyryl derivative mimic the effects of PTH on calcium metabolism in bone (Vaes 1968;Klein and Raisz 1971;Hermann-Erlee and v.d. Meer 1974) and in kidney (Burnatowska et al 1977;Borle and Uchikawa 1979;Wrenn and Biddulph 1979a, b).…”

Section: Parathyroid Hormonementioning

confidence: 99%

Control, modulation, and regulation of cell calcium

Borle

1981

Reviews of Physiology, Biochemistry and Pharmacology

299

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“…In spite of a number of important recent studies [1,3,4,7,11,13], many aspects of this regulation remain unclear. In the present studies, active transport of phosphate from the mucosal to the serosal bathing solution has been demonstrated in the isolated urinary bladder of the toad, Bufo marinus.…”

mentioning

confidence: 95%