Renal, gastrointestinal, and hemostatic effects of oral administration of meloxicam to Hispaniolan Amazon parrots (Amazona ventralis)

Dijkstra, B.; Guzmán, David Sánchez-Migallón; Gustavsen, Kate A.; Owens, Sean D.; Hass, Carlyle; Kass, Philip H.; Paul-Murphy, Joanne R

doi:10.2460/ajvr.76.4.308

Cited by 33 publications

(6 citation statements)

References 69 publications

(86 reference statements)

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“…Some avian species, such as vultures within the Gyps genus, have had significant adverse reactions to some nonsteroidal anti-inflammatory medications. While the long-term effects and tolerance of the medications prescribed in the current case have not been fully elucidated, studies have demonstrated safety of meloxicam administration in several avian species, including those sensitive to other nonsteroidal anti-inflammatory medications, over shorter administration durations [13–16]. No significant adverse clinical signs, clinicopathologic derangements, or radiographic abnormalities attributed to the administration of these medications were noted for the animal in this case.…”

Section: Discussionmentioning

confidence: 80%

Intertarsal Joint Stabilization in a Bateleur Eagle (Terathopius ecaudatus) Using a Novel Application of a Braided Suture and Titanium Button System

Gjeltema

Voe

Minter

et al. 2017

Case Reports in Veterinary Medicine

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A 32-year-old adult captive male bateleur eagle (Terathopius ecaudatus) with a history of laxity, degenerative joint disease, and varus deviation of the distal left hindlimb for several years was presented for evaluation of left hindlimb lameness and was diagnosed with chronic subluxation of the left intertarsal joint. After failing to improve with conservative management and pain medication, surgical stabilization of the joint was performed using a novel application of a braided suture and titanium button system. Unsatisfactory clinical improvement and postsurgical reevaluation indicated that the initial surgical stabilization was unsuccessful. The surgery was repeated, and the animal showed postsurgical improvement in intertarsal joint stability, weight-bearing, and lameness for a period of several years with use and adjustment of chronic pain medications. The novel surgical technique described in this case report represents an additional treatment option for management of avian intertarsal joint subluxations. Presurgical planning should consider the unique anatomic features and variability of the avian tarsometatarsus to avoid surgical complications.

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Section: Discussionmentioning

confidence: 80%

Intertarsal Joint Stabilization in a Bateleur Eagle (Terathopius ecaudatus) Using a Novel Application of a Braided Suture and Titanium Button System

Gjeltema

Voe

Minter

et al. 2017

Case Reports in Veterinary Medicine

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“…We targeted the COX pathway in these studies using a fairly conservative NSAID dosing regimen. Though higher or more frequent doses of meloxicam have been reported in the literature, they have not been evaluated for long‐term treatment for up to several weeks duration (Dijkstra et al, 2015; Sinclair et al, 2012). Miller et al (2019) additionally found that plasma concentrations dropped below therapeutic targets within 12 h in zebra finches treated with 1 or 2 mg/kg meloxicam intramuscularly, suggesting that our NSAID treatment may have only exerted any effect on inflammation half of the time.…”

Section: Discussionmentioning

confidence: 99%

Modulating disease phenotype in a songbird: A role for inflammation in disease tolerance?

Ruden

Adelman

2022

J Exp Zool Pt A

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Individual animals vary greatly in their responses to infection, either killing off the invading pathogen (resistance) or minimizing the per‐pathogen costs of infection on host fitness (tolerance). Though we understand little about the physiological drivers of tolerance in wild animals, phenotypically, it manifests as milder clinical signs of disease. Here, we use a well‐described disease system, finch mycoplasmosis, to evaluate the role of inflammation in disease tolerance. House finches (Haemorhous mexicanus) infected with the bacterial pathogen Mycoplasma gallisepticum (MG) develop conjunctival pathology that satisfies the cardinal signs of inflammation. We report on a captive trial performed in 2016 and replicated in 2018 that tested whether chemotherapeutics, specifically nonsteroidal anti‐inflammatory drugs (NSAIDs), can reduce lesion severity, thus pushing individuals toward more tolerant phenotypes. Though birds treated with NSAIDs in the first trial developed milder pathology per unit pathogen load, we found no effect of treatment in the second trial, perhaps due to natural variation in baseline tolerance within the source population across years. Second‐trial control birds developed markedly milder pathology than first‐year controls, suggesting that the effect of trial swamped the effect of treatment in this study. Moving forward, using birds from a population in which the disease is absent or only recently emerged—and so tolerance has not yet been selected for—may better elucidate the role of pro‐inflammatory mediators in disease tolerance.

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“…It has been reported that IM administration of MLX to quails at a dose of 2 mg/kg for 14 days (q 12 h) causes no significant changes in hematological, biochemical, and renal histopathology and only muscle necrosis develops in the injection site (Sinclair et al, 2012). In parrots, oral administration of MLX at a dose of 0.5 mg/kg for 14 days (q 12 h) and at a dose of 1.6 mg/kg for 15 days (q 12 h), has not cause hematological, biochemical, or histopathological changes (Dijkstra et al, 2015; Montesinos et al, 2015). While MLX does not alter the renal histopathology in zebra finches (1–2 mg/kg IM, q 12 h for 4 days), the degeneration and dilation of renal tubules have been reported in budgerigars (0.1 mg/kg IM for 3–5 days) (Miller et al, 2019; Pereira & Werther, 2007).…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of meloxicam, carprofen, and tolfenamic acid after intramuscular and oral administration in Japanese quails (Coturnix coturnix japonica)

Türk

Tekeli

Çorum

et al. 2021

Vet Pharm & Therapeutics

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The aim of this study was to determine the pharmacokinetics of meloxicam (MLX), carprofen (CRP), and tolfenamic acid (TA) in Japanese quails (Coturnix coturnix japonica) following intramuscular (IM) and oral administration at doses of 1, 10, and 2 mg/kg, respectively. A total of 72 quails were randomly divided into 3 equal groups as MLX, CRP, and TA. Each group was separated into two sub‐groups that received IM and oral administration of each drug. Plasma concentrations of MLX, CRP, and TA were determined using HPLC‐UV and analyzed by non‐compartmental method. The t1/2ʎz and MRT of MLX, CRP, and TA after oral administration were similar to those after IM administration. The Vdarea/F of MLX, CRP, and TA after IM administration was 0.28, 2.05, and 0.20 L/kg. The Cl/F of MLX, CRP, and TA after IM administration was 0.12, 0.19, and 0.09 L/h/kg. MLX, CRP, and TA after oral administration showed significantly lower Cmax and longer Tmax compared with IM administration. The relative bioavailability of MLX, CRP, and TA following oral administration in quails was 76.13%, 61.46%, and 57.32%, respectively. The IM and oral route of MLX, CRP, and TA can be used for the treatment of various conditions in quails. However, further research is necessary to determine the pharmacodynamics and safety of MLX, CRP, and TA before use in quails.

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Renal, gastrointestinal, and hemostatic effects of oral administration of meloxicam to Hispaniolan Amazon parrots (Amazona ventralis)

Abstract: Meloxicam administered orally at the dosage used in this study caused no apparent negative changes in several renal, gastrointestinal, or hemostatic variables in healthy Hispaniolan Amazon parrots. Additional studies to evaluate adverse effects of NSAIDs in birds will be needed.

Cited by 33 publications

References 69 publications

Intertarsal Joint Stabilization in a Bateleur Eagle (Terathopius ecaudatus) Using a Novel Application of a Braided Suture and Titanium Button System

Intertarsal Joint Stabilization in a Bateleur Eagle (Terathopius ecaudatus) Using a Novel Application of a Braided Suture and Titanium Button System

Modulating disease phenotype in a songbird: A role for inflammation in disease tolerance?

Pharmacokinetics of meloxicam, carprofen, and tolfenamic acid after intramuscular and oral administration in Japanese quails (Coturnix coturnix japonica)

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