Renal Function in the Separate Kidneys of Man. I. Hemodynamics and Excretion of Solute and Water in Normal Subjects *

Hulet, William H.; Baldwin, David S.; Biggs, Albert W.; Gombos, Ervin A.; Chasis, Herbert

doi:10.1172/jci104049

Cited by 55 publications

(11 citation statements)

References 8 publications

(11 reference statements)

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“…Absolute blood flow in the right kidney may not necessarily be equal to that in the left kidney. Hulet et al 16 have demonstrated that the median percentage difference in C PAH is 5.12% in a study in which split PAH clearance was measured by ureteral catheterization as an index for renal plasma flow. They also reported that functional differences in excess of 15% are abnormal on the basis of their observations.…”

Section: Discussionmentioning

confidence: 99%

Measurement of renal blood flow in human subjects using the ultrasound velocity profiling technique

et al. 2006

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Section: Discussionmentioning

confidence: 99%

Measurement of renal blood flow in human subjects using the ultrasound velocity profiling technique

et al. 2006

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“…The subjects assumed the recumbent position about 1 hour before study and remained recumbent during study. Urine was collected from the separate kidneys according to previously described techniques (11). The ureteral catheters were allowed to drain directly into graduated cylinders containing mineral oil.…”

Section: Methodsmentioning

confidence: 99%

The Excretion of Acid in Unilateral Renal Disease in Man*

Steinmetz¹,

Eisinger²,

Lowenstein³

1965

J. Clin. Invest.

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“…Ureteral catheterization and the subsequent determination of filtration rate (GFR), renal plasma flow (RPF), TmPAH, and sodium, solute and water excretion (UN.V, Uo.mV and V) by the separate kidneys were performed according to the technique and methods outlined in the preceding paper (2). Calculations were made of sodium excretion fraction (EFNS), solute excretion fraction (EFo,m) and the per cent contribution of sodium and its attendant anion to the total urine osmolality (UNai/Uo.m X 100).…”

Section: Methodsmentioning

confidence: 99%

Renal Function in the Separate Kidneys of Man. Ii. Hemodynamics and Excretion of Solute and Water in Essential Hypertension *†

Baldwin¹,

Hulet²,

Biggs³

et al. 1960

J. Clin. Invest.

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The frequent coincidence of hypertension and renal disease is universally recognized, and it has been proposed that all hypertensive disease, including essential hypertension, somehow or other has its origin in the kidneys. This interpretation would be favored by the demonstration of one or more defects in renal function early in the course of essential hypertension. Although the presumed causal defect may, of course, be bilateral, the only feasible approach to this problem at the present time appears to lie in the functional comparison of the separate kidneys, which might reveal some subtle impairment not evident in bilateral studies.In 1941, Chasis and Redish (1) examined 21 patients with essential hypertension by conventional methods and found that both kidneys were, grossly at least, equally affected. At that time, no data were available on the natural variability of function in the two kidneys of normotensive individuals. We have extended these observations by examining function in the separate kidneys, by ureteral catheterization, in 21 normotensive and 50 additional hypertensive subjects with respect to filtration rate, renal plasma flow, TmPAH, sodium, total solute and water excretion.In the preceding paper (2) compares the incidence of functional disparity in patients with essential hypertension to our normotensive group and also describes patterns of renal functional impairment which have been derived from correlating disparities in sodium and solute excretion. METHODSObservations were made in 50 patients with essential hypertension selected from the wards and outpatient clinic of the Third (New York University) Medical Division of Bellevue Hospital. Patients were chosen with minimal retinal and cardiac abnormalities according to heart X-ray, electrocardiogram and funduscopic examination, and the majority were judged to be in the early stage of essential hypertension. Patients known or suspected of having gross renal arterial or urologic disease were excluded.The group consists of 43 female and 7 male patients between the ages of 14 and 65 years. All patients were maintained on the regular hospital diet. Fluids were withheld for 15 hours and the test was performed in the morning with the subjects in a fasting state.Ureteral catheterization and the subsequent determination of filtration rate (GFR), renal plasma flow (RPF), TmPAH, and sodium, solute and water excretion (UN.V, Uo.mV and V) by the separate kidneys were performed according to the technique and methods outlined in the preceding paper (2). Calculations were made of sodium excretion fraction (EFNS), solute excretion fraction (EFo,m) and the per cent contribution of sodium and its attendant anion to the total urine osmolality (UNai/Uo.m X 100).The data were examined to determine the incidence of disparities for each function according to the normal limits of difference between the two kidneys as established in the normotensive group. RESULTSValues for GFR, RPF, TmPAH, V, UNa, Uosm and derived data in the separate kidneys of 50 hypertensive pat...

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Renal Function in the Separate Kidneys of Man. I. Hemodynamics and Excretion of Solute and Water in Normal Subjects *

Cited by 55 publications

References 8 publications

Measurement of renal blood flow in human subjects using the ultrasound velocity profiling technique

Measurement of renal blood flow in human subjects using the ultrasound velocity profiling technique

The Excretion of Acid in Unilateral Renal Disease in Man*

Renal Function in the Separate Kidneys of Man. Ii. Hemodynamics and Excretion of Solute and Water in Essential Hypertension *†

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