Measurement of renal blood flow in human subjects using the ultrasound velocity profiling technique

Takano, Ryuichi; Taniguchi, Nobuyuki; Itoh, Kouichi; Kusano, Eiji

doi:10.1007/s10396-005-0088-1

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…First, para-aminohippurate would provide a more specific measure of renal perfusion. However, renal ultrasound is strongly correlated to effective renal blood flow when flows are above 280 ml min -1 as seen this study (46). Second, muscle sympathetic nerve activity was recorded in a subset of individuals and used as a surrogate for renal sympathetic nerve activity.…”

Section: Experimental Limitations and Considerationsmentioning

confidence: 86%

Global REACH 2018: renal oxygen delivery is maintained during early acclimatization to 4,330 m

Steele

Tymko

Meah

et al. 2020

American Journal of Physiology-Renal Physiology

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Early acclimatization to high-altitude is characterized by various respiratory, hematological, and cardiovascular adaptations that serve to restore oxygen delivery to tissue. However, less is understood about renal function and the role of renal oxygen delivery (RDO2) during high-altitude acclimatization. We hypothesized that: 1) RDO2 would be reduced after 12-hours of high-altitude exposure (high-altitude day1) but restored to sea-level values after one-week (high-altitude day7); and 2) RDO2 would be associated with renal reactivity (RR), an index of acid-base compensation at high-altitude. Twenty-four healthy lowlander participants were tested at sea-level (344m; Kelowna, Canada), on day1 and day7 at high-altitude (4330m; Cerro de Pasco, Peru). Cardiac output, renal blood flow, arterial and venous blood sampling for renin-angiotensin-aldosterone-system hormones and NT pro-B type natriuretic peptides were collected at each time point. RR was calculated as: (Δ arterial bicarbonate)/(Δ partial pressure of arterial carbon dioxide) between sea-level and high-altitude day1, and sea-level and high-altitude day7. The main findings were: 1) RDO2 was initially decreased at high-altitude compared to sea-level (ΔRDO2: -22±17%, P<0.001), but was restored to sea-level values on high-altitude day7 (ΔRDO2: -6±14%, P=0.36). The observed improvements in RDO2 resulted from both changes in renal blood flow (Δ from high-altitude day1: +12±11%; P=0.008), and arterial oxygen content (Δ from high-altitude day1 +44.8±17.7%; P=0.006); and 2) RR was positively correlated with RDO2 on high-altitude day7 (r=0.70; P<0.001), but not high-altitude day1 (r=0.26; P=0.29). These findings characterize the temporal responses of renal function during early high-altitude acclimatization, and the influence of RDO2 in the regulation of acid-base.

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Section: Experimental Limitations and Considerationsmentioning

confidence: 86%