Renal Function and Kidney Size Following Hypophysectomy in Man

Falkheden, Thomas; Wickbom, Ingmar

doi:10.1530/acta.0.0480348

Cited by 45 publications

(20 citation statements)

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“…There is substantial evidence that growth hormone affects renal function (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Growth hormone excess, whether from endogenous hypersecretion or chronic exogenous administration, has been associated with an increase in renal blood flow, glomerular filtration rate (1)(2)(3)(4)(5)(6), and increased levels of serum phosphate (7-9, 13-15).…”

Section: Introductionmentioning

confidence: 99%

“…Brush border membrane vesicles prepared from the renal cortex of dogs treated with growth hormone for 3 d had an increase in sodium-dependent phosphate uptake (16). Likewise, hypophysectomized animals had a reduction in renal blood flow and glomerular filtration rate, effects reversed by growth hormone administration (1,10,11). Selective growth hormone deficiency, induced by administration ofa synthetic peptide antagonist to growth hormone releasing factor, resulted in a reduction in glomerular filtration rate and increased the fractional excretion of phosphate ( 12).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of growth hormone and insulin-like growth factor I on rabbit proximal convoluted tubule transport.

Quigley¹,

Baum

1991

J. Clin. Invest.

114

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This in vitro microperfusion study examined the effects of growth hormone and insulin-like growth factor I (IGF-I) on proximal convoluted tubule (PC1) transport. Tubules were perfused with an ultrafiltrate-like solution and bathed in a serumlike albumin solution. Neither a physiologic (5 X 10-10 M), nor a pharmacologic (5 X 10j-M) dose of growth hormone had an effect on PCT phosphate or bicarbonate transport, or volume absorption. Addition of 5,x 10-9 M and 5 X 108 M IGF

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of growth hormone and insulin-like growth factor I on rabbit proximal convoluted tubule transport.

Quigley¹,

Baum

1991

J. Clin. Invest.

114

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“…Abbreviations used in this paper: HCT, hematocrit; IGF, insulin-like growth factor; MABP, mean arterial blood pressure; PAH, para-aminohippurate; RPF, renal plasma flow rate; RVR, renal vascular resistance. mone levels have increased RPF and GFR (2). After pituitary ablation, RPF and GFR fall to normal; this fall precedes the reduction in kidney size (2).…”

Section: Introductionmentioning

confidence: 99%

“…mone levels have increased RPF and GFR (2). After pituitary ablation, RPF and GFR fall to normal; this fall precedes the reduction in kidney size (2). Moreover, injections of growth hormone in man increase RPF and GFR.…”

Section: Introductionmentioning

confidence: 99%

Evidence that insulin-like growth factor I increases renal plasma flow and glomerular filtration rate in fasted rats.

Hirschberg¹,

Kopple²

1989

J. Clin. Invest.

192

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The mechanisms whereby growth hormone may increase renal plasma flow (RPF) and GFR are not known, but circumstantial evidence has implicated insulin-like growth factor I (IGF-I) as a -mediator of this effect. This study examined whether an infusion of IGF-I will increase RPF and GFR, whether this effect occurs quickly, and if this effect is dependent on eicosanoids or peptide hormones known to affect renal function. Rats fasted for 3 d to reduce IGF-I and IGF-I plasma binding proteins were anesthetized; then the rats received an intravenous injection of 25 Mg/kg IGF-I, and an infusion of 25 ;Lg/kg IGF-I within 20 min. Controls received infusion of the vehicle. RPF (para-aminohippurate clearances), GFR (inulin clearances), renal vascular resistance (RVR), mean arterial blood pressure (MABP), plasma IGF-I, and glucose concentrations were measured repeatedly. At the end of the 20-min infusion, plasma IGF-I tended to be increased in the animals that received IGF-I (P = 0.069), but did not increase in the control rats. IGF-I induced a significant and sustained fall in RVR and rise in RPF and GFR without any change in MABP. A small, transient, but significant decrease in plasma glucose concentrations was observed during IGF-I but not during vehicle infusion. Indomethacin, but not somatostatin, blocked the renal response to IGF-I infusion. Thus, IGF-I infusion increases RPF and GFR and reduces RVR in fasted rats. This effect requires the presence of eicosanoids but does not seem to require other peptide hormones suppressed by somatostatin.

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“…This is the reason why we evaluated changes in the GFR in acromegalic patients who have achieved remission by surgery alone. This reduction in the GFR after hypophysectomy in patients with acromegaly was reported as early as 1965 (25). Recently, Sze et al reported a decrease in the GFR after transsphenoidal surgery in 20 cured and four non-cured patients with acromegaly (26).…”

Section: Discussionmentioning

confidence: 93%

Treatable glomerular hyperfiltration in patients with active acromegaly

Shimizu

Takano

Arimura

et al. 2016

European Journal of Endocrinology

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Objective: The glomerular filtration rate (GFR) is increased in patients with active acromegaly. The aim of this study is to elucidate whether renal function deteriorates in patients with acromegaly and whether this deterioration is reversible after surgical remission. Design/methods: A case-control study of 48 acromegalic patients who were surgically cured (cases) and 48 patients with nonfunctioning pituitary adenomas (NFomas, controls) was conducted. We performed clinical and biochemical examinations before surgery and 3 months post-surgery. The GFR of each patient was estimated (estimated GFR, eGFR) using their serum creatinine, age, sex, and body surface area, and postoperative changes in the eGFR were assessed. Results: The preoperative eGFR was significantly higher in patients with acromegaly than in those with NFoma (99.8 vs 75.1 mL/min respectively, P < 0.01). In acromegalic patients, surgical remission was accompanied by a significant decline in the eGFR (from 99.8 to 86.2 mL/min, P < 0.01). Conversely, in patients with NFoma, the postoperative eGFR did not change significantly (from 75.1 to 81.9 mL/min, P = 0.12). Among the acromegalic patients, the postoperative decreases in the eGFR were more prominent in patients with a preoperatively high or normal vs low eGFR. Conclusions: Our data demonstrated a significant post-surgical eGFR decrease in patients with acromegaly, but not in patients with NFomas. This change in the eGFR was reversible in acromegalic patients with a high/normal preoperative eGFR, but not in those with a low preoperative eGFR. This suggests that the reversible pathophysiological change in some patients is functional but not organic.

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Renal Function and Kidney Size Following Hypophysectomy in Man

Cited by 45 publications

References 0 publications

Effects of growth hormone and insulin-like growth factor I on rabbit proximal convoluted tubule transport.

Effects of growth hormone and insulin-like growth factor I on rabbit proximal convoluted tubule transport.

Evidence that insulin-like growth factor I increases renal plasma flow and glomerular filtration rate in fasted rats.

Treatable glomerular hyperfiltration in patients with active acromegaly

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