Renal elimination of some 99mTc-labelled cysteamine derivatives

Preparation and structural studies of neutral oxorhenium(V) complexes with D-penicillamine methyl ester

“…Compared with tetradentate N 2 S 2 ligands having pendant carboxyl groups, 4,6 very few studies have been devoted to the composition and structure of oxo complexes of Tc V and Re V with mercaptoamino acids and their derivatives, despite a continuous interest in the biological behaviour of 99m Tc complexes † E-Mail: johannsen@fz-rossendorf.de of cysteine and derivatives. [7][8][9][10][11][12] Recently profound solution studies of the oxorhenium() penicillamine complex have been described, 13,14 including the observation that NH deprotonation does not occur in this system up to a very high pH value. Having studied the complexation behaviour of Tc V and Re V with cysteamine as the simple N,S-donor building block of the ligands of interest, we extended our investigations to -penicillamine methyl ester.…”