Renal effects and injury induced by animal toxins

Sitprija, Visith; Sitprija, Siravit

doi:10.1016/j.toxicon.2012.06.012

Cited by 70 publications

(62 citation statements)

References 110 publications

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“…Due to its high vascularity, the kidney is highly susceptible to toxins44. The snakes of the genus Bothrops and Crotalus can cause severe systemic reactions, and acute kidney injury (AKI) is one of the most severe complications of snakebites2.…”

Section: Introductionmentioning

confidence: 99%

ACUTE KIDNEY INJURY CAUSED BY Crotalus AND Bothrops SNAKE VENOM: A REVIEW OF EPIDEMIOLOGY, CLINICAL MANIFESTATIONS AND TREATMENT

Albuquerque¹,

Jacinto

Silva

et al. 2013

Rev. Inst. Med. trop. S. Paulo

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SUMMARYOphidic accidents are an important public health problem due to their incidence, morbidity and mortality. An increasing number of cases have been registered in Brazil in the last few years. Several studies point to the importance of knowing the clinical complications and adequate approach in these accidents. However, knowledge about the risk factors is not enough and there are an increasing number of deaths due to these accidents in Brazil. In this context, acute kidney injury (AKI) appears as one of the main causes of death and consequences for these victims, which are mainly young males working in rural areas. Snakes of the Bothrops and Crotalus genera are the main responsible for renal involvement in ophidic accidents in South America. The present study is a literature review of AKI caused by Bothrops and Crotalus snake venom regarding diverse characteristics, emphasizing the most appropriate therapeutic approach for these cases. Recent studies have been carried out searching for complementary therapies for the treatment of ophidic accidents, including the use of lipoic acid, simvastatin and allopurinol. Some plants, such as Apocynaceae, Lamiaceae and Rubiaceae seem to have a beneficial role in the treatment of this type of envenomation. Future studies will certainly find new therapeutic measures for ophidic accidents.

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Section: Introductionmentioning

confidence: 99%

ACUTE KIDNEY INJURY CAUSED BY Crotalus AND Bothrops SNAKE VENOM: A REVIEW OF EPIDEMIOLOGY, CLINICAL MANIFESTATIONS AND TREATMENT

Albuquerque¹,

Jacinto

Silva

et al. 2013

Rev. Inst. Med. trop. S. Paulo

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“…Nevertheless, the quick return of the PP to the basal values could be explained by (1) the direct lesion of the basal membrane of glomerular capillaries due to the elevated PP (Alves et al 2005) and/or by (2) the presence of pore formation peptides in the venom, as known for other scorpion species (Sitprija and Sitprija 2012). Taken together, these factors could contribute to the increase in the GFR and UF, as well as to the intratubular protein deposits in the proximal and distal convoluted tubules as observed in the histological analysis.…”

Section: Discussionmentioning

confidence: 99%

Effects of Tityus stigmurus (Thorell 1876) (Scorpiones: Buthidae) venom in isolated perfused rat kidneys

Silva

Albuquerque

Jorge³

et al. 2016

An. Acad. Bras. Ciênc.

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Scorpions belonging to the Tityus genus are of medical interest in Brazil. Among them, Tityus stigmurus is the main scorpion responsible for stings in the Northeast region. After a sting, the scorpion venom distributes rapidly to the organs, reaching the kidneys quickly. However, there are few studies concerning the renal pathophysiology of scorpion poisoning. In this study, we evaluated the effects of T. stigmurus venom (TsV) on renal parameters in isolated rat kidneys. Wistar rats (n = 6), weighing 250-300 g, were perfused with Krebs-Henseleit solution containing 6 g/100 mL bovine serum albumin. TsV at 0.3 and 1.0 μg/mL was tested, and the effects on perfusion pressure (PP), renal vascular resistance (RVR), urinary fl ow (UF), glomerular fi ltration rate (GFR), and electrolyte excretion were analyzed. Effects were observed only at TsV concentration of 1.0 μg/mL, which increased PP ( control PP 40' = 92.7 ± 1.95; TsV PP 40' = 182.0 ± 4.70 * mmHg, * p < 0.05), RVR ( control RVR 40' = 3.28 ± 0.23 mmHg; Tst RVR 40' = 6.76 ± 0.45 * mmHg, * p < 0.05), UF ( control UF 50' = 0.16 ± 0.04; Tst UF 50' = 0.60 ± 0.10 * mL/g/min, * p < 0.05), GFR and electrolyte excretion, with histological changes that indicate renal tubular injury. In conclusion, T. stigmurus venom induces a transient increase in PP with tubular injury, both of which lead to an augmented electrolyte excretion.

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“…5 The renal histology mainly consists of acute tubular necrosis and acute interstitial nephritis, while glomerular changes are rare. 1 Abdominal pain is a common feature. The presence of abdominal pain and its severity is correlated with the severity of coagulopathy, neurotoxicity, kidney involvement.…”

Section: Ir/jarcmmentioning

confidence: 99%

“…Renal involvement has so many different features such as proteinuria, hematuria and renal failure. 1 Renal damage may be the reason of hypovolemia and hypoperfusion, thrombotic microangiopathy, rhabdomyolysis and of venom cytotoxicity on the renal tubules. 2 Glomerular lesions are not seen frequently, but there are rare reports of proliferative and rapidly progressive glomerulonephritis.…”

mentioning

confidence: 99%

Unusual presentations of acute kidney injury and neurologic complications due to snake bite

Noshad¹,

Rikhtegar²,

Hagdoost³

et al. 2015

J Anal Res Clin Med

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Renal effects and injury induced by animal toxins

Cited by 70 publications

References 110 publications

ACUTE KIDNEY INJURY CAUSED BY Crotalus AND Bothrops SNAKE VENOM: A REVIEW OF EPIDEMIOLOGY, CLINICAL MANIFESTATIONS AND TREATMENT

ACUTE KIDNEY INJURY CAUSED BY Crotalus AND Bothrops SNAKE VENOM: A REVIEW OF EPIDEMIOLOGY, CLINICAL MANIFESTATIONS AND TREATMENT

Effects of Tityus stigmurus (Thorell 1876) (Scorpiones: Buthidae) venom in isolated perfused rat kidneys

Unusual presentations of acute kidney injury and neurologic complications due to snake bite

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