Renal Clear Cell Carcinoma Appearing as a Left Neck Mass

Abstract

Malignant clear cell tumors of the head and neck are uncommon. Primary tumors may arise from the salivary glands, thyroid gland, or parathyroid glands, while metastatic tumors most commonly arise from the lungs, kidneys, and female genital tract. Renal cell carcinoma is the third most common metastatic tumor to the bone and soft tissues of the head and neck. Despite this, there have been few reported cases of renal clear cell carcinoma metastases to the neck. Here we report a unique case of an otherwise asymptomatic young woman with a left neck mass as the first clinical sign of advanced renal clear cell carcinoma.

Metastases to the thyroid gland: seventeen cases operated on in a single clinical center

“…In clinical papers, the incidence is low and, according to various sources, amounts to 2-3% of all malignant tumors of the thyroid [1,2]. In postmortem examinations, the value ranges from 1.25 to 24.2% and is usually associated with cancer dissemination through blood from a distant focus or with a direct involvement of the thyroid gland by a neoplastic process situated in the adjacent organs [3][4][5][6]. The location of the primary focus is also diversified.…”

Primary clear cell carcinoma of the nasopharynx

“…This carcinoma most often afflicts persons in their sixth or seventh decade, with no gender or racial predilection. [1][2][3] Clear cell carcinoma of minor salivary glands have been reported in the nasal cavity, paranasal sinuses, oral cavity, and larynx. However, primary clear cell carcinoma of the nasopharynx has not been reported yet in the literature.…”

Metastatic Cervical Lymph Nodes from Urogenital Tract Carcinoma: A Diagnostic and Therapeutic Challenge

“…The clear cell variant of follicular carcinoma of the thyroid should be considered in the differential diagnosis of renal cell carcinoma metastatic to the thyroid gland. Several reports have con rmed that a metastatic lesion may be the initial manifestation of a silent renal carcinoma (5,(25)(26)(27). Most reports are of single or very small numbers of cases (25)(26)(27)(28)(29)(30).…”

“…Several reports have con rmed that a metastatic lesion may be the initial manifestation of a silent renal carcinoma (5,(25)(26)(27). Most reports are of single or very small numbers of cases (25)(26)(27)(28)(29)(30). Gottlieb and Roland (28) described 3 cases of renal cell carcinoma with metastases to the head and neck region at presentation without evidence of disease elsewhere.…”