Renal cell carcinoma with metastasis to the thyroid gland

Pitale, Shailesh; Sizemore, Glen W.; Bakhos, Rima; DeJong, Steven; Flanigan, Robert C.; Emanuele, Nicholas V.

doi:10.1016/s1078-1439(00)00065-x

Cited by 16 publications

(9 citation statements)

References 9 publications

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“…However, 25.1% are incidentally noted on physical examination or imaging studies to have metastases of NTMs to the thyroid gland. Some authors have suggested that the screening chest CT in patients being followed up with cancers should be a thyroid-chest CT not to miss thyroid metastases (25). It is likely that increasing use of imaging technologies, such as PET, have led to the increase frequency of detected metastases of NTMs to the thyroid gland.…”

Section: Discussionmentioning

confidence: 99%

“…Notably, several cases, including the first of two cases reported later in this review, occurred in the setting of a preexisting multinodular goiter or thyroid nodule. In some reports thyroid metastases were suspected because there was enlargement of a preexisting nodule or goiter (22)(23)(24)(25)(26)(27)111,112). The most commonly reported NTMs to metastasize to an abnormal thyroid gland were RCC (n = 14), lung (n = 3), and sarcoma (n = 3).…”

Section: Metastases To Abnormal Thyroid Glandsmentioning

confidence: 99%

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Metastases to the Thyroid: A Review of the Literature from the Last Decade

Chung

Tran

Brumund

et al. 2012

Thyroid

258

378

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It is important to keep in mind that the thyroid gland can be a site of metastases for a variety of tumors when evaluating a thyroid nodule, especially in a patient with a prior history of malignancy. In patients with thyroid lesions and a history of malignant disease, regardless of time elapsed since the initial diagnosis of the primary neoplasm, disease recurrence or progression of malignancy must be considered until proven otherwise.

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Section: Discussionmentioning

confidence: 99%

Section: Metastases To Abnormal Thyroid Glandsmentioning

confidence: 99%

Metastases to the Thyroid: A Review of the Literature from the Last Decade

Chung

Tran

Brumund

et al. 2012

Thyroid

258

378

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“…In 31 patients (15 women, 15 men, and one unknown gender), the authors reported the presence of nonthyroidal metastases [7,8,9,11,12,13,15,22,23,28,30,31,33,45,47,49,51,52,56,62]. Secondary nonthyroidal lesions in women vs. men were 27.3 vs. 21.7% (lungs), 18.2 vs. 8.7% (pancreas), 13.6 vs. 26.1% (skeletal), 13.6 vs. 13% (lymph nodes), 9.1 vs. 8.7 (liver), and 9.1 vs. 4.3% (adrenal glands); the remaining metastases being localized in other organs or tissues.…”

Section: Nonthyroidal Metastasesmentioning

confidence: 99%

Thyroid Metastases from Renal Cell Carcinoma: Review of the Literature

Sindoni

Rizzo

Tuccari

et al. 2010

The Scientific World JOURNAL

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The thyroid gland is a rare site of clinically detectable tumor metastasis and kidneys are frequently the site of the parent malignancy. In the present review on thyroid metastases from renal cell carcinoma, cases were searched on PubMed by entering the strings: “renal carcinoma [or“hypernephroma”] AND thyroid metastasis/metastases”. Thus, we retrieved a total of 111 cases that were published between 1964 and 2007, a total that became 113 by adding two patients observed by us. The female to male ratio was 1.35:1. The primary renal cancer was almost always unilateral (90%) (with no significant side preference) and only rarely bilateral (9% in men, 4% in women), whereas bilaterality of thyroid metastases was relatively more frequent (28%). Thyroid metastasis from renal cancer was commonly single with a unique node that appears solid and hypoechoic at ultrasonography, approximately 9 years after nephrectomy. Concordance of lateralization was insignificantly greater for the right kidney/right thyroid lobe pattern (54%) than for the left kidney/left thyroid lobe pattern (40%), regardless of gender. Finally, survival was longer for women. Thyroid metastases, even if rare in the clinical practice, must be considered in the differential diagnosis of a thyroid nodule, particularly in patients who have a history of malignancies.

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“…A significant contributor to the delayed diagnosis is poor patient recall of the primary surgery, because a considerable time may elapse before metastasis appear [6,7]. This results in a vital 'missed link' of history and a cursory general examination may fail to note the large nephrectomy scar.…”

Section: Discussionmentioning

confidence: 99%

“…T he initial diagnosis of renal cell carcinoma, has improved due to availability of imaging modalities [1]. While bone, lymph nodes and lungs constitute expected 'homing' sites, metastasis may turn up at unusual locations [2][3][4][5][6][7]. The failure to consider RCC as a source of a metastasis, can be attributed as much to 'missing' the nephrectomy scar, as not considering the possibility on a cytologic examination of the metastasis.…”

Section: Introductionmentioning

confidence: 99%